Lifeboat Foundation: Safeguarding Humanity
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A decade in the making, NASA and SpaceX have set May 27 as the target launch date for the first crewed space mission to launch into orbit from U.S. soil since the retirement of the space shuttle in 2011.

NASA astronauts Doug Hurley and Bob Behnken, two veterans of the shuttle program, will ride SpaceX’s Crew Dragon spacecraft into orbit on top of a Falcon 9 rocket from pad 39A at NASA’s Kennedy Space Center in Florida. That’s the same historic launch facility used by the last space shuttle flight.

Liftoff time on May 27 is expected to be around 4:32 p.m. EDT (2032 GMT), when the Earth’s rotation brings the launch pad under the orbital plane of the International Space Station.

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Talk being ahead of the curve;

Event 201 was a 3.5-hour pandemic tabletop exercise that simulated a series of dramatic, scenario-based facilitated discussions, confronting difficult, true-to-life dilemmas associated with response to a hypothetical, but scientifically plausible, pandemic. 15 global business, government, and public health leaders were players in the simulation exercise that highlighted unresolved real-world policy and economic issues that could be solved with sufficient political will, financial investment, and attention now and in the future.

The exercise consisted of pre-recorded news broadcasts, live “staff” briefings, and moderated discussions on specific topics. These issues were carefully designed in a compelling narrative that educated the participants and the audience.

The Johns Hopkins Center for Health Security, World Economic Forum, and Bill & Melinda Gates Foundation jointly propose these recommendations.

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The discovery that immune T cells have a spectrum of responsiveness could shed light on how our immune system responds to infections and cancer, and what goes wrong in immune diseases. Researchers at the Wellcome Sanger Institute, Open Targets, Biogen, GSK and their collaborators found that T cells responded very differently to immune signals the more ‘training’ they had been exposed to, rather than being a simple switch from naïve to experienced. This could help guide research into finding drug targets for immune diseases such as asthma and rheumatoid arthritis.

Today’s study (14th April), published in Nature Communications, also revealed that even highly trained memory T cells are less rigidly specialized than previously thought, and are able to respond to new immune signals. This has implications for immune research, and could help understand for example how the body responds to infections.

T cells are key white blood cells that fight infection and disease, and act like police directing the immune system response. Babies are born with inexperienced — naïve — T cells, which change as they come into contact with bacteria or viruses, to create specific memory T cells that can ‘remember’ fighting against these infections. These memory T cells can then react more quickly the next time they meet the same threat, telling the immune system to remove the infection rapidly. This is how vaccination protects against disease, by delivering a safe form of an invading virus or bacterium, to train our immune system by building up specific memory T cells.

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Scientists are one step closer to adapting the bacteria-killing power of a naturally occurring nanomachine, a tiny particle that performs a mechanical action.

In a study published in Nature, a UCLA-led team of researchers describe how the nanomachine recognizes and kills bacteria, and report that they have imaged it at atomic resolution. The scientists also engineered their own versions of the nanomachine, which enabled them to produce variations that behaved differently from the naturally occurring version.

Their efforts could eventually lead to the development of new types of antibiotics that are capable of homing in on specific species of microbes. Drugs tailored to kill only a certain species or strain of bacteria could offer numerous advantages over conventional antibiotics, including lowering the likelihood that bacteria will develop resistance. In addition, the tailored drugs could destroy harmful cells without wiping out beneficial bugs in the gut microbiome, and they could eventually offer the possibilities of being deployed to prevent bacterial infections, to kill pathogens in food and to engineer human microbiomes so that favorable bacteria thrive.

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NASA and SpaceX are targeting May 27 for the launch of Demo-2, the first launch of NASA astronauts from the U.S. since 2011 and the first crewed launch for Elon Musk’s space company.

As its name implies, Demo-2 will be the second time the company launches its Crew Dragon capsule to the International Space Station. But, unlike Demo-1 last year, this time two astronauts will be on board – a pair that will be the first NASA astronauts to launch from the U.S. since the end of the Space Shuttle program in 2011.

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Of the spread of COVID-19 aboard the aircraft carrier USS Theodore Roosevelt and the subsequent relief of its Commanding Officer has highlighted the tension that exists between maintaining military readiness and the need to safeguard the health of members of the armed forces in the face of a pandemic.

The disease has been a feature of war for the vast majority of human history – from the plague that ravaged Athens early in the Peloponnesian War, killing the Athenian strategos Pericles; to the diseases that European settlers brought with them to the New World, devastating local populations; to the host of tropical diseases that caused appalling casualties in the China-Burma-India and Southwest Pacific theaters in World War II. The fact that we were surprised by the emergence, growth, and spread of COVID-19 reflects the false conceit of 21st century life that we have “conquered” disease.

In fact, pandemics are but one class of low-probability but high-impact contingencies that we could face in the coming years, including an earthquake or other natural disaster in a major urban area, regime change in an important state, and the collapse of financial markets leading to a global depression. When I served as Deputy Assistant Secretary of Defense for Policy Planning between 2006 and 2009, we explored a series of such “shocks” as well as the role the Defense Department could play in responding to them as a way of helping the Department’s leaders address such contingencies. During my time in the Pentagon, we also held a series of wargames with members of Congress and their staff, governors of several states and their cabinets, and the government of Mexico, to explore in depth the consequences of a pandemic. Much of what we found then resonates with what we are experiencing now.

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