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An interdisciplinary team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA has developed a first-of-its-kind roadmap of how human skeletal muscle develops, including the formation of muscle stem cells.

The study, published in the peer-reviewed journal Cell Stem Cell, identified various cell types present in skeletal muscle tissues, from all the way to adulthood. Focusing on muscle progenitor cells, which contribute to muscle formation before birth, and muscle stem cells, which contribute to muscle formation after birth and to regeneration from injury throughout life, the group mapped out how the cells’ gene networks—which genes are active and inactive—change as the cells mature.

The roadmap is critical for researchers who aim to develop muscle stem cells in the lab that can be used in regenerative cell therapies for devastating muscle diseases, including muscular dystrophies, and sarcopenia, the age-related loss of muscle mass and strength.

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In the movie “Transformers,” cars morph into robots, jets or a variety of machinery. A similar concept inspired a group of researchers to combine gas foaming, which is a blend of chemicals that induces gas bubbling, and 3D molding technologies to quickly transform electrospun membranes into complex 3D shapes for biomedical applications.

In Applied Physics Reviews, the group reports on its new approach that demonstrates significant improvements in speed and quality compared with other methods. The work is also the first successful demonstration of formation of 3D neural constructs with an ordered structure through differentiation of human neural progenitor/ on these transformed 3D scaffolds.

“Electrospinning is a technology to produce nanofiber membranes,” said co-author Jingwei Xie, at the University of Nebraska Medical Center. “The physics principle behind it involves applying an electrical force to overcome the surface tension of a solution to elongate a solution jet into continuous and ultrafine fibers after solvent evaporation.”

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Circa 1990 to current o.o

The Woodward effect, also referred to as a Mach effect, is part of a hypothesis proposed by James F. Woodward in 1990.[1] The hypothesis states that transient mass fluctuations arise in any object that absorbs internal energy while undergoing a proper acceleration. Harnessing this effect could generate a reactionless thrust, which Woodward and others claim to measure in various experiments.[2][3]

Hypothetically, the Woodward effect would allow for field propulsion spacecraft engines that would not have to expel matter. Such a proposed engine is sometimes called a Mach effect thruster (MET) or a Mach Effect Gravitation al Assist (MEGA) drive.[4][5] So far, experimental results have not strongly supported this hypothesis,[6] but experimental research on this effect, and its potential applications, continues.[7]

The Space Studies Institute was selected as part of NASA’s Innovative Advanced Concepts program as a Phase I proposal in April 2017 for Mach Effect research.[8][9][10][11] The year after, NASA awarded a NIAC Phase II grant to the SSI to further develop these propellantless thrusters.[12][13].

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Circa 2017

Injecting DNA into injured horse tendons and ligaments can cure lameness, new research involving scientists at Kazan Federal University, Moscow State Academy and The University of Nottingham has found.

The gene therapy technology was used in horses that had gone lame due to injury and within two to three weeks the horses were able to walk and trot. Within just two months they were back to full health, galloping and competing.

The study has big implications not just for the veterinary world but the future of human medicine — injuries like these are common in people as well as animals, not just in lameness but in other illnesses and diseases from the legs and arms through to the back and hips.

Continue reading “Gene therapy can cure lameness in horses, research finds” | >