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I’ve been shocked sometimes when I walk in and see the patients. Most of the ones I’ve intubated are young — 30s, 40s, 50s. These are people who walked into the ER because they were coughing a day or two ago, or sometimes hours ago. By the time I come into the room, they are in severe respiratory distress. Their oxygen level might be 70 or 80 percent instead of 100, which is alarming. They are taking 40 breaths a minute when they should be taking 12 or 14. They have no oxygen reserves. They are pale and exhausted. It puts them in a mental fog, and sometimes they don’t hear me when I introduce myself. Some are panicky and gasping. Others are mumbling or incoherent. Last week, one patient was crying and asking to use my phone so they could call family and say goodbye, but their oxygen levels were dropping, and we didn’t have time, and I couldn’t risk bringing my phone in and contaminating it with virus, and the whole thing was impossible. I kept apologizing. I just —. I don’t know. I have to find a way to hold it together in order to do this job. I tear up sometimes, and if I do, it can fog up my face shield.


“It’s a powerless feeling, watching someone die”: An anesthesiologist on the frontline of coronavirus outbreak.

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    WASHINGTON — The Defense Advanced Research Projects Agency awarded Lockheed Martin a $5.8 million contract for satellite integration work for the Blackjack program, the company announced April 24.

    Blackjack is a project to deploy a constellation of 20 satellites in low Earth orbit by 2022 and demonstrate that a LEO system can provide global high-speed communications.

    Lockheed Martin will define and manage interfaces between Blackjack’s satellite buses, payloads and the so-called Pit Boss autonomous data processor. The work will be performed at the company’s satellite manufacturing plant in Sunnyvale, California.

    Saudi Arabia is to abolish flogging as a form of punishment, according to a legal document seen by media outlets.

    The directive from the Gulf kingdom’s Supreme Court says flogging will be replaced by imprisonment or fines.

    It says this is an extension of human rights reforms brought by King Salman and his son, the country’s de facto ruler Crown Prince Mohammed bin Salman.

    O,.,o.


    Throughout Syria’s lengthy conflict, Bellingcat has worked to investigate a large number of chemical attacks, including the nature of the weapons deployed in those attacks, using open source evidence. From modified chlorine cylinders to locally made surface to surface rockets filled with Sarin, Bellingcat has revealed the nature, and origin, of these chemical weapons, confirming the Syrian government’s involvement in a range of chemical attacks.

    Following a series of Sarin attacks in Al Lataminah and Khan Sheikhoun in March and April 2017, Bellingcat worked with open source evidence to slowly piece together the nature of the bomb used in the attacks. Bellingcat first published its conclusions in November 2017, and continued to build on the body of evidence it had uncovered. After the OPCW Investigation and Identification Team (IIT) report was published this week, confirming the type of bomb used in the March 24 and March 30, 2017 Sarin attacks in Al Lataminah, we now have their confirmation of the type of bomb used, the Syrian M4000 chemical bomb.

    Appropriate references can help observers determine the size of North Korean rockets with modest confidence. Using this method, the author has previously identified the unique North Korean SCUD-ER ballistic missile by establishing its body diameter at almost exact 1 meter instead of the common SCUD’s 0.88m width[1].

    Images from recent parades and test firing of North Korean rockets have offered more opportunities for relatively accurate estimation of the rockets’ dimensions. In this analysis, the author will present findings on the dimension of the missiles/ mock-ups exhibited in the April 15, 2017 parade in North Korea. The findings would in turn shed light on the technological sophistication of these weapon systems.

    The “new HS-10” .

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    MORGANTOWN, W.Va. – The West Virginia University Rockefeller Neuroscience Institute today announced a new study published in partnership with Weill Cornell Medical Center that demonstrates the successful opening of the blood brain barrier in the hippocampus and entorhinal cortex using focused ultrasound to treat six patients with early onset Alzheimer’s disease.

    This first-in-the-world study has been published in the Proceedings of the National Academy of Sciences journal. The effort is part of a Phase II clinical trial, sponsored by INSIGHTEC, which developed the technology and manufactures the focused ultrasound device, Exablate Neuro.

    “The blood brain barrier has long presented a challenge in treating the most pressing neurological disorders,” Ali Rezai, M.D., executive chair of the WVU Rockefeller Neuroscience Institute, said. “The ability to non-invasively and reversibly open the blood brain barrier in deep brain areas such as the hippocampus, offers a new potential in developing treatments for Alzheimer’s disease.”

    Results indicate that, early after birth, pioneer bacteria colonize the infant gut and by one month prophages induced from these bacteria provide the predominant population of virus-like particles. By four months of life, identifiable viruses that replicate in human cells become more prominent. Multiple human viruses were more abundant in stool samples from babies who were exclusively fed on formula milk compared with those fed partially or fully on breast milk, paralleling reports that breast milk can be protective against viral infections. Bacteriophage populations also differed depending on whether or not the infant was breastfed. We show that the colonization of the infant gut is stepwise, first mainly by temperate bacteriophages induced from pioneer bacteria, and later by viruses that replicate in human cells; this second phase is modulated by breastfeeding.

    Initially most of the viruses are bacteriophages, but as the abstract indicates, as time passes more and more of the viral community is made up of viruses that inhabit the human gut cells.

    The discussion focuses upon the finding that breastfeeding reduces the level of pathogenic viruses in the infants. That finding replicates other work based on different approaches. One of the infant cohorts included in this study was from Botswana, and the findings there are more pronounced than in their U.S. (Philadelphia)-based cohorts.

    In the African cohort, we not only found viruses that grow in human cells more commonly in exclusively formula-fed babies, but we also found more colonization in both feeding groups compared to US babies, emphasizing potential opportunities to intervene to reduce viral transmission to infants.

    The variation of microbiomes in different human populations is a really important component of human biological variability. Studies like this one are helping to show how that variation comes about through the development process and environmental exposures.