Lifeboat Foundation: Safeguarding Humanity
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Patients with spastic paraplegia type 15 develop movement disorders during adolescence that may ultimately require the use of a wheelchair. In the early stages of this rare hereditary disease, the brain appears to play a major role by over-activating the immune system, as shown by a recent study published in the Journal of Experimental Medicine.

The study was led by researchers at the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE). These findings could also be relevant for Alzheimer’s disease and other neurodegenerative conditions.

Spastic paraplegia type 15 is characterized by the progressive loss of neurons in the central nervous system that are responsible for controlling movement. Initial symptoms typically appear in late childhood, manifesting first in the legs in the form of uncontrollable twitching and paralysis.

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Our brain’s remarkable ability to form and store memories has long fascinated scientists, yet most of the microscopic mechanisms behind memory and learning processes remain a mystery. Recent research points to the importance of biochemical reactions occurring at postsynaptic densities—specialized areas where neurons connect and communicate. These tiny junctions between brain cells are now thought to be crucial sites where proteins need to organize in specific ways to facilitate learning and memory formation.

More specifically, a 2021 study revealed that memory-related proteins can bind together to form droplet-like structures at postsynaptic densities. What makes these structures particularly intriguing is their unique “droplet-inside-droplet” organization, which scientists believe may be fundamental to how our brains create lasting memories. However, understanding exactly how and why such complex protein arrangements form has remained a significant challenge in neuroscience.

Against this backdrop, a research team has developed an innovative computational model that reproduces these intricate protein structures. Their paper, published online in Cell Reports, explores the mechanisms behind the formation of multilayered protein condensates.

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Although the brain is our most complex organ, the ways to treat it have historically been rather simple.

Typically, surgeons lesioned (damaged) a structure or a pathway in the hope that this would “correct the imbalance” that led to the disease. Candidate structures for lesioning were usually found by trial and error, serendipity or experiments in animals.

While performing one such surgery in 1987, French neurosurgeon Alim-Louis Benabid noticed that the electrical stimulation he performed to locate the right spot to lesion had effects similar to the lesion itself.

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An avalanche is caused by a chain reaction of events. A vibration or a change in terrain can have a cascading and devastating impact.

A similar process may happen when living tissues are subject to being pushed or pulled, according to new research published in Nature Communications, by Northeastern University doctoral student Anh Nguyen and supervised by Northeastern physics professor Max Bi.

As , Bi and Nguyen use and mathematics to understand the mechanical processes that organisms undergo on a cellular level. With this more recent work, they have observed that when subjected to sufficient stress, tissues can “suddenly and dramatically rearrange themselves,” similar to how avalanches are formed in the wild.

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Scientists are finding clues for how to treat diabetes and hormone disorders in an unexpected place: a toxin from one of the most venomous animals on the planet.

An international research team led by University of Utah scientists has identified a component within the venom of a predatory marine cone snail, the geography cone, that mimics a human hormone called somatostatin, which regulates the levels of blood sugar and various hormones in the body. The hormone-like toxin’s specific, long-lasting effects, which help the snail hunt its prey, could also help scientists design better drugs for people with diabetes or hormone disorders, conditions that can be serious and sometimes fatal.

New research explores how one venom mimics a human hormone that regulates blood sugar, which could lead to better treatment for diabetes.

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Parkinson’s disease is a neurodegenerative disorder that is usually diagnosed in its late stage on the basis of clinical symptoms, mainly motor disorders. By this point, however, the brain is already severely and irreparably damaged. Moreover, diagnosis is difficult and often incorrect because the disease takes many forms, and symptoms overlap with other disorders.

Researchers from the PRODI Center for Protein Diagnostics at Ruhr University Bochum, Germany, and the biotech company betaSENSE have now discovered a biomarker in the that facilitates a reliable diagnosis at an early stage and can shed light on the progression of the disease and the effect of a therapy. They report their findings in the journal EMBO Molecular Medicine from April 25, 2025.

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