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Researchers harness AI-powered protein design to enhance T-cell based immunotherapies

A paper published in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in T-cell development and function.

These so-called soluble Notch agonists can be broadly applied to optimize clinical T-cell production and advance immunotherapy development.

Notch signaling is central to many cellular differentiation processes and is essential in transforming human immune cells into T-cells that target viruses and tumors. But activating Notch signaling in the laboratory has posed a challenge.

First Quantum Bit Made of Antimatter Captured in Physics Breakthrough

CERN scientists have analyzed a particle of antimatter isolated in an undecided quantum state known as a superposition for the first time.

While the quantum behavior of ordinary matter has been studied extensively and even used as the basis of quantum computers in the form of qubits, the breakthrough goes far beyond technological applications, potentially helping physicists understand why we even exist today.

The team suspended an antiproton – the antimatter counterpart of the proton – in a system of electromagnetic traps, and suppressed environmental interference that would mess with the particle’s delicate quantum state.

Windows 11’s Copilot app confirms GPT-5, Microsoft 365 Copilot, Azure prepares for GPT-5

GPT-5 could begin rolling out in the next few days, if everything goes to plan. There are enough evidences to confirm that Microsoft is preparing Copilot (its consumer-facing AI assistant), Microsoft 365 (primarily tailored for businesses and work), and Azure (enterprises/API customers) for GPT-5.

GPT-5, also referred to as GPT-5 alpha in early leaked benchmarks, is OpenAI’s next SOTA (State of the Art) model, and it has the potential to disrupt the AI industry again.

One source describes GPT-5 as phenomenal in coding, and it doesn’t look like it will be rolled out to just paid consumers, as even those without a subscription will be able to access it.

Revolutionizing 2D Electronics: Freestanding HZO Membranes Unlock High-κ Integration for Next-Gen Transistors

In a significant advancement for nanoelectronics, an international team of researchers from National Chung Hsing University, Kansai University, and National Cheng Kung University has developed a new strategy to integrate freestanding hafnium zirconium oxide (HZO) membranes into 2D field-effect transistors (FETs). This innovation, published in Nature Electronics, promises to overcome one of the main bottlenecks in the adoption of 2D semiconductors: the lack of scalable, high-κ dielectric integration.

Why 2D Semiconductors Need Better Gate Dielectrics

Two-dimensional semiconductors like molybdenum disulfide (MoS₂) have long been heralded as successors to silicon, offering exceptional electrical properties at atomically thin dimensions. However, their commercialization in logic devices has stalled due to a critical integration challenge: embedding a gate dielectric that both insulates and enables effective gate control.

Melanoma ‘cellular compass’ discovery could help curb metastasis

Researchers have discovered a protein which is critical for steering melanoma cancer cells as they spread throughout the body. The malignant cells become dependent on this protein to migrate, pointing to new strategies for impeding metastasis.

The protein eIF2A is generally thought to spring into action when a cell is under stress, helping ribosomes launch protein synthesis. But according to a study published in the journal Science Advances, eIF2A has a completely different role in melanoma, helping control movement.

“Malignant cells that metastasize need to make their way through tissues in order to invade proximal or distant organs. Targeting eIF2A could be a new strategy to impede melanoma breaking free and seeding tumors elsewhere,” says Dr. Fátima Gebauer, corresponding author of the study and researcher at the Center for Genomic Regulation (CRG) in Barcelona.