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May 15, 2019

Boosting Levels of NAD+ May Make Senescent Cells More Aggressively Inflammatory

Posted by in categories: biotech/medical, life extension

On senescent cells, mechanism of interaction and (potential?!) side effects of NAD+ supplements. “… Those people self-experimenting with NAD+ precursor supplementation should consider keeping a close eye on markers of inflammation…”


Enhancing levels of NAD+ in mitochondria via delivery of various precursor compounds as supplements is growing in popularity as an approach to boost faltering mitochondrial function and thus modestly slow the progression of aging. A human trial demonstrated improved vascular function as a result of nicotinamide riboside supplementation, for example. Researchers here show that increased NAD+ will likely make worse the inflammatory signaling of senescent cells, however. Senescent cells accumulate with age, and are an important cause of the chronic inflammation of aging that drives the progression of many age-related diseases.

The results here suggest that efficient senolytic treatments to selectively destroy senescent cells should proceed any of the current approaches to raising levels of NAD+ in older individuals — and it is an open question as to whether any of the existing available options are efficient enough to make NAD+ enhancement safe in the longer term. Those people self-experimenting with NAD+ precursor supplementation should consider keeping a close eye on markers of inflammation.

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May 15, 2019

Now hiring for project ‘Rejuvenation Now’ …

Posted by in category: life extension

If you are an MD or scientist interested in bringing evidence-based rejuvenation therapies to a broader audience, this is for you!


Help to accelerate the access to Rejuvenation Therapies.

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May 15, 2019

Nawa’s carbon nanotube ultra-capacitors are going into mass production

Posted by in categories: energy, nanotechnology, transportation

Charging almost instantly and offering massive power density, Nawa’s innovative ultracapacitors are ready to make a mark across industries from automotive to power tools and aviation. And after raising more than US$10 million, this French company is going into mass production.

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May 14, 2019

For The First Time, Scientists Turn Human Stem Cells Into Insulin-Producing Cells

Posted by in categories: biotech/medical, innovation

May have posted this, but this is very cool. “We can now generate insulin-producing cells that look and act a lot like the pancreatic beta cells you and I have in our bodies,” explains one of the team, microphysiologist Matthias Hebrok from the University of California San Francisco (UCSF).


Although treatment of type 1 diabetes has come a long way since it was first described in Ancient Egypt, insulin injections and finger pricks are a daily part of life for many diabetics.

But researchers have just made a breakthrough that might one day make these technologies obsolete, by transforming human stem cells into functional insulin-producing cells (also known as beta cells) – at least in mice.

Continue reading “For The First Time, Scientists Turn Human Stem Cells Into Insulin-Producing Cells” »

May 14, 2019

Anti-Aging Passion and Pragmatism: Effective Bedfellows at Last

Posted by in categories: geopolitics, life extension

I am writing this shortly after returning from the third edition of RAADfest, a conference created two years ago by a team led by Jim Strole. I go to a lot, I mean a lot, of conferences, not least because outreach is such a big part of my role in our crusade. But I think this is the first time I have chosen to devote an editorial to one. You may wonder what’s so special.

Well, RAADfest is … not your typical conference. Its organizers—Strole and his team, most notably his partner Bernadeane—have, for a couple of decades, led a group in Arizona named “People Unlimited”, which has acquired a reputation—and, I have to report, a well-deserved one—for, let’s say, placing excessive emphasis on the principle that ‘‘where there’s a will there’s a way’’ in relation to the defeat of aging (Yeah, I can still do classic British understatement when I try). Accordingly, when they first let it be known that they planned to do something bigger, the initial reaction was decidedly mixed. I don’t know how many credentialed biogerontologists declined speaking invitations, but only a few of us accepted—and of those, as I recall, only the perennially fearless Michael Rose was a university professor. I myself, though happy to lend my support to this new initiative as a speaker, was rather more diffident in response to Strole’s entreaties to promote the event through my outreach channels.

But the doubters were wrong—very wrong. The event was a storming success, in terms of both attendance—Strole had secured significant sponsorship from the Life Extension Foundation under the expectation of a budgetary shortfall but was actually able to give it back, yes you read that correctly—and also content, which, while being necessarily a little light on science given the paucity of scientist speakers, was coherent, rousing, and informative.

Continue reading “Anti-Aging Passion and Pragmatism: Effective Bedfellows at Last” »

May 14, 2019

A Popular Bone and Joint Supplement Has Surprising Heart Health Benefits

Posted by in category: health

It may do more for heart health than joint pain.

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May 14, 2019

Thwarting Protein Reverses Brain Decline in Aged Mice

Posted by in categories: biotech/medical, neuroscience

Blocking an immune-related molecule lodged in blood vessels stops memory loss.

  • By Simon Makin on May 14, 2019

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May 14, 2019

How stressed-out gut bacteria may trigger autoimmune response

Posted by in category: biotech/medical

Stressful life events most likely contribute to autoimmune diseases, but scientists don’t have a deep understanding of the underlying chain of events. A study on mice published this week in mSystems suggests that the gut microbiota may play a significant role in that connection. Researchers found that the onset of stress caused changes in the intestinal bacteria that, in turn, stimulated the activity of immune cells in a way that increased the likelihood that the body would a…


Chronic social stress in mice induces the expression of virulent genes in the gut microbiota. The altered microbiota increases the presence of effector T helper cells in the lymph nodes and induces myelin autoreactive cells. Exposure to chronic stress, therefore, may increase the risk of developing autoimmune diseases for some individuals with a susceptibility.

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May 14, 2019

Moon: Exploration is in our DNA and our closest celestial friend, the Moon, is a treasure chest of science!

Posted by in categories: biotech/medical, science, space

As we look forward to #Moon2024 mission, we’re sharing these highlights of our favorite neighbor taken from the International Space Station and Earth:


Photographs of the moon taken by astronauts in space and individuals on Earth.

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Continue reading “Moon: Exploration is in our DNA and our closest celestial friend, the Moon, is a treasure chest of science!” »

May 14, 2019

SpaceX’s Orbital Internet Could Restore Net Neutrality

Posted by in categories: internet, space travel

But neither SpaceX nor Musk have announced plans to do so.

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