Lifeboat Foundation

The generation of a chemical system capable of replication and evolution is a key objective of synthetic biology. This could be achieved by in vitro reconstitution of a minimal self-sustaining central dogma consisting of DNA replication, transcription and translation. Here, we present an in vitro translation system, which enables self-encoded replication and expression of large DNA genomes under well-defined, cell-free conditions. In particular, we demonstrate self-replication of a multipartite genome of more than 116 kb encompassing the full set of Escherichia coli translation factors, all three ribosomal RNAs, an energy regeneration system, as well as RNA and DNA polymerases. Parallel to DNA replication, our system enables synthesis of at least 30 encoded translation factors, half of which are expressed in amounts equal to or greater than their respective input levels. Our optimized cell-free expression platform could provide a chassis for the generation of a partially self-replicating in vitro translation system.

BF16, the new number format optimized for deep learning, promises power and compute savings with a minimal reduction in prediction accuracy.

BF16, sometimes called BFloat16 or Brain Float 16, is a new number format optimised for AI/deep learning applications. Invented at Google Brain, it has gained wide adoption in AI accelerators from Google, Intel, Arm and many others.

The idea behind BF16 is to reduce the compute power and energy consumption needed to multiply tensors together by reducing the precision of the numbers. A tensor is a three-dimensional matrix of numbers; multiplication of tensors is the key mathematical operation required for AI calculations.

Wall Street’s Biotech Investment Wizard — On this most recent ideaXme (http://radioideaxme.com/) episode, I was honored to be joined by my friend, and biotech / pharma / healthcare investment banker extraordinaire, Frederick Frank, to talk about his 50-year career history behind the industry’s mega-deals — #Ideaxme #Biopharma #Biotech #WallStreet #Mergers #Acquisitions #VentureCapital #Genentech #Roche #BristolMyersSquibb #PrivateEquity #Health #Wellness #Longevity #Regeneration #LifeExtension #Aging #IraPastor #Bioquark #Regenerage

Ira Pastor, ideaXme exponential health ambassador, interviews Fred Frank, Founder and Chair of Evolution Life Science Partners, an investment bank focused on the needs of life sciences and healthcare companies.

Continue reading “Biotech’s Wizard Of Wall Street : Fred Frank At The Forefront of Investment” »

Researchers suggest probiotic SLIC system could be adapted to generate and deliver a wide variety and combination of immunotherapeutics against different tumor types.

Cities change as they grow — not only by adding area or population but also in a variety of other ways, from the length and width of their roads to economic growth to the distribution of elementary schools. Social scientists often clash over the best way to measure change as a city swells. Traditionally, they’ve taken a cross-sectional approach, which means collecting data on a large number of cities of diverse sizes at the same moment in time. More recently, some researcher…

New work reconciles divergent methods used to analyze the scaling behavior of cities.

A region beneath the rough waters of the North Sea, known as Doggerland, holds archaeological clues to the past. Watch how researchers are using advances in mapping and leads from dredging sites to piece together the history of this vanished landscape.

Read the story: https://www.sciencemag.org/news/2020/01/relics-washed-beache…-north-sea

Continue reading “Maps of a now-submerged land help reconstruct the lives of ancient Europeans” »

This is the first-ever 3D-printed human heart model using human cells #ValentinesDay

A theoretical study reveals that, in certain situations, some materials might heat up more quickly after first being cooled.

Still, the fact that many labs worldwide are capable of printing viruses is worrisome.

A few years ago, for instance, Canadian researchers alarmed the scientific community when they assembled synthetic horsepox in a lab — a virus closely related to smallpox, which killed hundreds of millions before researchers developed a vaccine.

The same technique, the researchers said at the time, could be be used to bring back smallpox, giving terrorists tools to set off a deadly pandemic.