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Traversal Emerges From Stealth With $48 Million From Sequoia And Perkins To Reimagine Site Reliability In The AI Era

With more code created by AI, there is more surface area to troubleshoot. There is a need for AI to autonomously troubleshoot, mediate and even prevent complex incidents at scale—self-healing codegen.

Gene-editing system targets multiple organs simultaneously

A gene-editing delivery system developed by UT Southwestern Medical Center researchers simultaneously targeted the liver and lungs of a preclinical model of a rare genetic disease known as alpha-1 antitrypsin deficiency (AATD), significantly improving symptoms for months after a single treatment, a new study shows.

Gene-editing nanoparticle system targets multiple organs simultaneously

A gene-editing delivery system developed by UT Southwestern Medical Center researchers simultaneously targeted the liver and lungs of a preclinical model of a rare genetic disease known as alpha-1 antitrypsin deficiency (AATD), significantly improving symptoms for months after a single treatment, a new study shows. The findings, published in Nature Biotechnology, could lead to new therapies for a variety of genetic diseases that affect multiple organs.

“Multi-organ diseases may need to be treated in more than one place. The development of multi-organ-targeted therapeutics opens the door to realizing those opportunities for this and other diseases,” said study leader Daniel Siegwart, Ph.D., Professor of Biomedical Engineering, Biochemistry, and in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern.

Gene editing—a group of technologies designed to correct disease-causing mutations in the genome—has the potential to revolutionize medicine, Dr. Siegwart explained. Targeting these technologies to specific organs, tissues, or will be necessary to effectively and safely treat patients.

Artificial neural networks reveal how peripersonal neurons represent the space around the body

The brains of humans and other primates are known to execute various sophisticated functions, one of which is the representation of the space immediately surrounding the body. This area, also sometimes referred to as “peripersonal space,” is where most interactions between people and their surrounding environment typically take place.

Researchers at Chinese Academy of Sciences, Italian Institute of Technology (IIT) and other institutes recently investigated the neural processes through which the brain represents the area around the body, using brain-inspired computational models. Their findings, published in Nature Neuroscience, suggest that receptive fields surrounding different parts of the body contribute to building a modular model of the space immediately surrounding a person or (AI) agent.

“Our journey into this field began truly serendipitously, during unfunded experiments done purely out of curiosity,” Giandomenico Iannetti, senior author of the paper, told Medical Xpress. “We discovered that the hand-blink reflex, which is evoked by electrically shocking the hand, was strongly modulated by the position of the hand with respect to the eye.