Guest: David Shumaker, USA
Utilizing neurotransmitters as a passport into the brain:
Safe and efficient delivery of blood-brain barrier (BBB)–impermeable cargos into the brain through intravenous injection remains a challenge. Here, we developed a previously unknown class of neurotransmitter–derived lipidoids (NT-lipidoids) as simple and effective carriers for enhanced brain delivery of several BBB-impermeable cargos. Doping the NT-lipidoids into BBB-impermeable lipid nanoparticles (LNPs) gave the LNPs the ability to cross the BBB. Using this brain delivery platform, we successfully delivered amphotericin B (AmB), antisense oligonucleotides (ASOs) against tau, and genome-editing fusion protein (−27)GFP-Cre recombinase into the mouse brain via systemic intravenous administration. We demonstrated that the NT-lipidoid formulation not only facilitates cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination. This class of brain delivery lipid formulations holds great potential in the treatment of central nervous system diseases or as a tool to study the brain function.
The ASTHROS mission will be carried on a big balloon that will be about 150 meters wide — or roughly the size of a football stadium — and will be inflated with helium. A carrier below the balloon will hold the instruments and the telescope. During its flight, it will allow scientists to control the direction of the telescope with precision and download the data in real-time using satellite links.
The ASTHROS team expects that stratospheric winds will help the balloon complete two to three loops around the South Pole in approximately 21 to 28 days. Once complete, the parachute will return the carrier to the ground and the telescope will be recovered and refurbished for future missions.
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Circa 2018
Warehouses are being revolutionized by AI and robotics, and British supermarket chain Ocado is at the forefront of this change. We went inside the company’s new facilities to see how technology is affecting how you shop online.
Face Masks Archives
Posted in futurism
We’re going back to Mars, and we’d like you to be our virtual guest on the trip. On July 30, NASA will launch the Mars 2020 Perseverance rover on a seven-month journey to the Red Planet. After landing in Jezero Crater, the robotic astrobiologist and scientist will search for signs that microbes might have lived on Mars long ago, collect soil samples to be returned to Earth on a future mission and pave the way for human exploration beyond the Moon. Perseverance will be accompanied by a helicopter called Ingenuity, the first attempt at powered flight on another world.
Because of the coronavirus pandemic and in the interest of health and safety, NASA can’t invite you to Florida to watch the launch personally. However, there are many ways you can participate virtually:
Magnetic waves into matter :3.
PDF | The generalized Breit-Wheeler process, i.e., the emission of e+e− pairs off a probe photon propagating through a polarized short-pulsed… | Find, read and cite all the research you need on ResearchGate.
Science Fiction explores themes and warns about scenarios where sentient Artificial Intelligence (AI) becomes dangerous and harms, enslaves, or annihilates Humanity. Variations of these ideas occur across popular drama.
Vector The Robot Boy
Posted in robotics/AI
I need him as my desk pet!!!
Special thanks to: instagram.com/hancorinne_ tiktok.com/@vector.robot.boy
Get the Anki Vector Robot Sidekick at Amazon: https://amzn.to/39oX5u6
It’s also available at Walmart here!: https://bit.ly/2BnIFxE
During collective cell migration, directional information is transmitted from a leading edge to the follower cells as a form of ERK activation waves. Hino et al. demonstrate that a mechanochemical feedback loop coupling cell deformation and ERK activation enables sustained propagation of the directional information over a tissue-scale expanse.