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David Sinclair wants to slow down and ultimately reverse aging. Sinclair sees aging as a disease and he is convinced aging is caused by epigenetic changes, abnormalities that occur when the body’s cells process extra or missing pieces of DNA. This results in the loss of the information that keeps our cells healthy. This information also tells the cells which genes to read. David Sinclair’s book: “Lifespan, why we age and why we don’t have to”, he describes the results of his research, theories and scientific philosophy as well as the potential consequences of the significant progress in genetic technologies.

At present, researchers are only just beginning to understand the biological basis of aging even in relatively simple and short-lived organisms such as yeast. Sinclair however, makes a convincing argument for why the life-extension technologies will eventually offer possibilities of life prolongation using genetic engineering.

He and his team recently developed two artificial intelligence algorithms that predict biological age in mice and when they will die. This will pave the way for similar machine learning models in people.
The loss of epigenetic information is likely the root cause of aging. By analogy, If DNA is the digital information on a compact disc, then aging is due to scratches. What we are searching for, is the polish.

Every time a cell divides, the DNA strands at the ends of your chromosomes replicate in order to copy all the genetic information to each new cell, and this process is not perfect. Over time, however, the ends of your chromosomes can become scrambled.

However, the progress in genetic engineering has proved that these changes can be reversed even at the cellular level, and it is possible to restore the information in our cells, thus improving the functioning of our organs and slowing the aging process.

#Aging #DavidSinclair #Lifespan

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For mouthless, lungless bacteria, breathing is a bit more complicated than it is for humans.

We inhale oxygen and exhale carbon dioxide; Geobacter — a ubiquitous, groundwater-dwelling genus of bacteria — swallow up organic waste and ‘exhale’ electrons, generating a tiny electric current in the process.

Those waste electrons always need somewhere to go (usually into a plentiful underground mineral like iron oxide), and Geobacter have an unconventional tool to make sure they get there.

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#DigitalTheology #TheologyofDigitalPhysics #PhenomenalConsciousness #CosmicSelf #HolographicPrinciple #DigitalPhysics #theology #pantheism #consciousness

Since we live in a world which isn’t random, but organized at every level, a role for consciousness seems unavoidable. The ‘digital theologian’ shows us compelling evidence from quantum mechanics, mathematics and computer sciences, which not only aligns with a philosophical worldview of the Primacy of Consciousness, but which also assigns a role to information as its modus operandi.

It is quantum mechanics which appears to connect the Universe as a whole to consciousness. A whole, which is more than the sum of its parts and irreducible to mere assumptions deriving from the anatomizing dissection into mental confabulations. Drawing from the holographic principle, perceptroniums and noocentrism, Alex provides crucial keys to unlock the mystery of consciousness to show us how our local consciousness can arise from a non-local cosmic consciousness network.

Carefully building his fortress of arguments, Alex gathers his building bricks from various areas of scientific exploration, ranging from the role of language and tools in the development of our consciousness, the physics of time and epigenetics. Traditional Darwinism and reductive materialism become so challenged, that we become bound to agree with Terence McKenna’s statement that “object fetishism is completely bankrupt.” All these threads are then skillfully woven into the irresistible attractor and only logical conclusion, or Digital Pantheism and Omega Point Cosmology. And with this thus synthesized Apotheosis, Vikoulov brings the architecture of his chef-d’oeuvre to full fruition.

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Researchers in Singapore have built a refrigerator that’s just three atoms big.

This quantum fridge won’t keep your drinks cold, but it’s cool proof of physics operating at the smallest scales. The work is described in a paper published in Nature Communications (“Quantum absorption refrigerator with trapped ions”).

Researchers have built tiny ‘heat engines’ before, but quantum fridges existed only as proposals until the team at the Centre for Quantum Technologies at the National University of Singapore chilled with their atoms.

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Summary: PLCG2-P522R, a genetic variant that protects against Alzheimer’s disease, enhances key functions of immune cells.

Source: University of Eastern Finland

A new study conducted by researchers at the University of Eastern Finland found that the PLCG2-P522R genetic variant, which protects against Alzheimer’s disease, enhances several key functions of immune cells. The results obtained in the study highlight the importance of immune cells as a target of future development of new therapies for Alzheimer’s disease.

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Neanderthals have adopted male sex chromosome from modern humans.

In 1997, the very first Neanderthal DNA sequence — just a small part of the mitochondrial genome — was determined from an individual discovered in the Neander Valley, Germany, in 1856. Since then, improvements in molecular techniques have enabled scientists at the Max Planck Institute for Evolutionary Anthropology to determine high quality sequences of the autosomal genomes of several Neanderthals, and led to the discovery of an entirely new group of extinct humans, the Denisovans, who were relatives of the Neanderthals in Asia.

However, because all specimens well-preserved enough to yield sufficient amounts of DNA have been from female individuals, comprehensive studies of the Y chromosomes of Neanderthals and Denisovans have not yet been possible. Unlike the rest of the autosomal genome, which represents a rich tapestry of thousands of genealogies of any individual’s ancestors, Y chromosomes have a peculiar mode of inheritance — they are passed exclusively from father to son. Y chromosomes, and also the maternally-inherited mitochondrial DNA, have been extremely valuable for studying human history.

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