Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 7767

Yan McMullen had never heard of the USC Dornsife College of Letters, Arts and Sciences when he started casting about for a graduate chemistry program. But on the recommendation of one of his professors, he sent an email to the College’s Professor of Chemistry Stephen Bradforth proposing an experiment to tease out what makes a metal really a metal.

The proposal would not only turn into his Ph.D. thesis but a major scientific breakthrough.

McMullen’s proposal was not an easy sell. The experiment would be expensive and possibly dangerous.

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The role genetics and gut bacteria play in human health has long been a fruitful source of scientific enquiry, but new research marks a significant step forward in unraveling this complex relationship. Its findings could transform our understanding and treatment of all manner of common diseases, including obesity, irritable bowel syndrome, and Alzheimer’s disease.

The international study, led by the University of Bristol and published today in Nature Microbiology, found specific changes in DNA — the chains of molecules comprising our genetic make-up — affected both the existence and amount of particular bacteria in the gut.

Lead author Dr David Hughes, Senior Research Associate in Applied Genetic Epidemiology, said: “Our findings represent a significant breakthrough in understanding how genetic variation affects gut bacteria. Moreover, it marks major progress in our ability to know whether changes in our gut bacteria actually cause, or are a consequence of, human disease.”

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A newly discovered Alzheimer’s gene may drive the first appearance of amyloid plaques in the brain, according to a study led by researchers at Columbia University Irving Medical Center.

Some variants of the gene, RBFOX1, appear to increase the concentration of protein fragments that make up these plaques and may contribute to the breakdown of critical connections between neurons, another early sign of the disease.

The finding could lead to new therapies that prevent Alzheimer’s and better ways of identifying people with the greatest risk of developing the disease.

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“The local government units and the public are strongly reminded that entry into the 4-km radius permanent danger zone must be strictly prohibited due to the further possibilities of sudden and hazardous steam-driven or phreatic eruptions,” the institute warned.

The Phivolcs said that it has recorded 136 volcano-tectonic earthquakes—earthquakes caused by the movement of magma beneath the surface of the Earth—on the western flanks during the 24-hour observation period.

It added that four of these earthquakes recorded between 1 a.m. to 2.06 a.m. on Monday were felt in La Carlota City and Bago City in Negros Occidental province and Canlaon City in Negros Oriental province.

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A 7.4 magnitude earthquake was felt off the southern coast of Mexico in the state of Oaxaca, prompting a forecast of potential tsunami waves, the country’s National Seismological Service reported Tuesday afternoon.

The quake occurred at 10:29 a.m. central time, with an epicenter near El Coyul, 6.8 miles southwest of Santa María Zapotitlán in Oaxaca. The damage in the state is considered light to moderate according to the U.S. Geological Survey (USGS).

The USGS estimates the earthquake itself could result in as many as 100 fatalities and $100 million in damage.

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The virus SARS coronavirus 2 (SARS-CoV-2) is the known cause of coronavirus disease 2019 (COVID-19). The “spike” or S protein facilitates viral entry into host cells.

Now a group of researchers from Seoul National University in South Korea, University of Cambridge in UK, and Lehigh University in USA, have worked together to produce the first open-source all-atom models of a full-length S . The researchers say this is of particular importance because the S protein plays a central role in viral entry into cells, making it a main target for vaccine and antiviral drug development.

The details can be found in a paper, “Developing a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein Model in a Viral Membrane” just published online in The Journal of Physical Chemistry B.

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