Lifeboat Foundation

Today, it’s common knowledge, but it took scientists centuries to figure out.

CD19 chimeric antigen receptor (CAR) T-cell therapy seems feasible, safe, and efficacious for patients with different autoimmune diseases, according to a study published in the Feb. 22 issue of the New England Journal of Medicine.

Fabian Müller, M.D., from the Friedrich-Alexander University Erlangen-Nürnberg in Germany, and colleagues examined patients with severe systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, or systemic sclerosis (eight, three, and four patients, respectively) who received a single infusion of CD19 CAR T-cells after fludarabine and cyclophosphamide preconditioning.

Efficacy was assessed up to two years after CAR T-cell infusion, measured using the Definition of Remission in SLE (DORIS) remission criteria, American College of Rheumatology-European League against Rheumatism (ACR-EULAR) major clinical response, and the score on the European Scleroderma Trials and Research Group (EUSTAR) activity index.

Recently, a research team from Pohang University of Science and Technology (POSTECH) has employed metasurfaces to fabricate angle-dependent holograms with multiple functions. This technology allows holograms to display multiple images based on the observer’s viewing angle. The findings were published in Nano Letters.

Objects can appear distinct depending on the viewer’s position, a concept that can be harnessed in holographic technology to generate cinematic and realistic 3D holograms presenting different images based on the viewing angle. However, the current challenge lies in controlling light dispersion according to the angle, making the application of nano-optics in this context a complex endeavor.

The team addressed this challenge by leveraging metasurfaces, artificial nanostructures capable of precisely manipulating the characteristics of light. These metasurfaces are incredibly thin and lightweight, approximately one-hundredth the thickness of a human hair, making them promising for applications in miniaturized displays such as virtual and augmented reality devices.

Forward-looking: As consumers increasingly turn toward digital distribution and data center operators try various storage methods, optical discs haven’t stopped evolving. A recently published paper explains how manufacturers could make DVD-like discs that hold the equivalent of hundreds or thousands of Blu-rays.

Researchers at the University of Shanghai for Science and Technology have developed an optical disc with a capacity of over a petabit of data, equivalent to well over 100 terabytes. Although the technology is primarily proposed for enterprise use, it could potentially become accessible to consumers after overcoming significant obstacles.

The scientists were able to significantly increase the capacity of an optical disc by implementing a 3D planar recording architecture. The technology uses a highly transparent, uniform photoresist film doped with aggregation-induced emission dye and stimulated by femtosecond lasers.

In a novel experiment, physicists have observed long range quantum coherence effects due to Aharonov-Bohm interference in a topological insulator-based device. This finding opens up a new realm of possibilities for the future development of topological quantum physics and engineering.

This finding could also affect the development of spin-based electronics, which may potentially replace some current electronic systems for higher energy efficiency and may provide new platforms to explore quantum information science.

The research, published in the February 20 issue of Nature Physics, is the culmination of more than 15 years of work at Princeton. It came about when Princeton scientists developed a quantum device —called a bismuth bromide (α-Bi₄Br₄) topological insulator—only a few nanometers thick and used it to investigate quantum coherence.

The trick is to outsmart the immune system.

“Lynch syndrome also known as HNPCC (Hereditary Non-Polyposis Colorectal Cancer) is an autosomal dominant condition that increases the risk of developing certain cancers, particularly bowel cancer. It results from mutations in genes that help to correct errors during DNA replication. Lynch syndrome patients have a higher incidence of bowel cancer in their lifetime and such other cancers as endometrial, ovarian, stomach and urinary tract cancers. These patients have an earlier presentation, i.e. younger age group. People with this condition face a much higher risk of developing colorectal cancer at ages below 50 years. This underscores the need for an early diagnosis through screening and surveillance in individuals having Lynch syndrome so that it can be detected rather earlier when it would be more easily treatable,” says Dr Tanveer Abdul Majeed, Consultant, Surgical Oncology, Kokilaben Dhirubhai Ambani Hospital Navi Mumbai.

“To effectively tackle Lynch syndrome-related cancers, early detection is vital. Screening protocols typically involve genetic testing to identify individuals at risk and surveillance measures, such as regular colonoscopies, starting at a younger age. Genetic counselling plays a pivotal role in Lynch syndrome management, providing affected individuals and their families with personalized risk assessments, guidance on screening strategies, and support in making informed decisions regarding preventive measures, including prophylactic surgery,” says Dr Kanuj Malik, Sr. Consultant-Surgical Oncology, Yatharth Hospitals.

Spin waves offer a new approach to digital computing’s counterpart.

Flying taxis could even replace short-haul flights, but certification and new digital infrastructure must happen first.