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O,.o earth to Mars 12.5 minutes.


A NASA scientist has cooked up plans for a bonkers new rocket engine that can reach close to the speed of light – without using any fuel.

Travelling at such speeds, the theoretical machine could carry astronauts to Mars in less than 13 minutes, or to the Moon in just over a second.

However, the real purpose of the so-called “helical engine” would be to travel to distant stars far quicker than any existing tech, according to NASA engineer Dr David Burns.

Summary: Researchers explore the close relationship between depression and pain. For some people, unexplained symptoms of pain, such as back or headaches, could be an early indicator of depression before mood changes occur.

Source: Mayo Clinic

Pain and depression are closely related. Depression can cause pain – and pain can cause depression. Sometimes pain and depression create a vicious cycle in which pain worsens symptoms of depression, and then the resulting depression worsens feelings of pain.

Humans are not the only species facing a potential threat from SARS-CoV-2, the novel coronavirus that causes COVID-19, according to a new study from the University of California, Davis.

An international team of scientists used genomic analysis to compare the main cellular receptor for the virus in humans—angiotensin converting enzyme-2, or ACE2—in 410 different species of vertebrates, including birds, fish, amphibians, reptiles and mammals.

ACE2 is normally found on many different types of cells and tissues, including epithelial cells in the nose, mouth and lungs. In humans, 25 amino acids of the ACE2 protein are important for the virus to bind and gain entry into cells.

Ahead of a likely ban on the US federal government’s use of Chinese-made quadcopters, including popular DJI drones, the Department of Defense has approved the products of five US-based unmanned air vehicle (UAV) makers for government use.

Those companies are Altavian, Parrot, Skydio, Teal and Vantage Robotics.

Small UAVs from these manufacturers have been deemed cyber-secure by the Pentagon – not vulnerable to backdoor spying that some suspect might be possible from the video cameras and other sensors attached to Chinese-made DJI drones. The US Congress is considering banning the US federal government from using foreign-made drones as part of its 2021 National Defense Authorization Act.

We always wonder how that “Eureka Moment” turns up…but truth may lie in the “High and Mighty”.


Cracked.com’s new book is now on sale. What follows is one of the classic articles that appear in the book, along with 18 new articles that you can’t read anywhere else.

Any dreadlocked white guys finding this article after Googling “Drugs Rule” should know that we’ve given this list about drugs a rule. To make the cut, an accomplishment has to be considered great by people who could pass a field sobriety test. So no Grateful Dead music. We’re sure someone somewhere has enjoyed the Dead perfectly sober, just as there are probably non-Christians who listen to Christian Rock. But we’re just as sure that in the grand scheme of things, those people don’t count.

In fact, because we’re masochists, we gave ourselves a strict no music policy, leaving us with … well, not a whole lot actually. Turns out most great things were accomplished by people who just said no, at least immediately prior to accomplishing them. Except for these five.

Metabolic plasticity allows cancer cells to adjust their metabolic phenotypes to adapt in hostile environments. There is an urgent need to understand the cross-talk between gene regulation and metabolic pathways underlying cancer metabolic plasticity. We establish a theoretical framework to decode the coupling of gene regulation and metabolic pathways. Our work characterizes a hybrid metabolic state where cells can use both glycolysis and oxidative phosphorylation (OXPHOS) and a possible metabolically inactive state where cells have low activity of both glycolysis and OXPHOS. We show that targeting both OXPHOS and glycolysis may be necessary to eliminate cancer aggressiveness. Our work serves as a platform to target abnormal metabolism in cancer by modulating both genes and metabolic pathways.

Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis and metastasis. However, it is still largely unknown how cancer cells orchestrate gene regulation to balance their glycolysis and OXPHOS activities. Previously, by modeling the gene regulation of cancer metabolism we have reported that cancer cells can acquire a stable hybrid metabolic state in which both glycolysis and OXPHOS can be used. Here, to comprehensively characterize cancer metabolic activity, we establish a theoretical framework by coupling gene regulation with metabolic pathways. Our modeling results demonstrate a direct association between the activities of AMPK and HIF-1, master regulators of OXPHOS and glycolysis, respectively, with the activities of three major metabolic pathways: glucose oxidation, glycolysis, and fatty acid oxidation.