Lifeboat Foundation

One day, cell and gene therapies will be as common as small molecules and antibody-based therapies are today, according to panelists at BIO’s June 8 virtual session, “The Next Generation of Medicine: Cell Therapies, Gene Therapies and Beyond.”

Because cell and gene therapies have the potential to address complex biological issues such as dysregulation, translocation and mutations, they can use that power to change what the body is doing.

“So, while small molecules and antibody therapies will still be around 30 years from now, they will be less important. Cell and gene therapies will dominate,” James Sabry, global head of pharma partnering at Roche, said.

Speed as important as size in predicting potentially damaging impacts of coronal mass ejections.

Space weather forecasters need to predict the speed of solar eruptions, as much as their size, to protect satellites and the health of astronauts, scientists have found.

Continue reading “Scientists Find Speed Key to Protecting Astronauts and Satellites From Space Storms” »

More time was allotted for the United Launch Alliance team to make repairs to ground system equipment. Liftoff atop an Atlas V rocket is set for 6:15 a.m. PT (9:15 a.m. ET, 1315 UTC). https://go.nasa.gov/2JvRbLq

Our newest water-seeking rover just booked a ride to the Moon’s South Pole.

Pittsburgh-based Astrobotic has been selected to deliver VIPER to the Moon in 2023 in preparation for future #Artemis missions to bring humanity to the lunar surface: https://go.nasa.gov/2YsxZFw

A memristor¹ has been proposed as an artificial synapse for emerging neuromorphic computing applications^2,3. To train a neural network in memristor arrays, changes in weight values in the form of device conductance should be distinct and uniform³. An electrochemical metallization (ECM) memory^4,5, typically based on silicon (Si), has demonstrated a good analogue switching capability^6,7 owing to the high mobility of metal ions in the Si switching medium⁸. However, the large stochasticity of the ion movement results in switching variability. Here we demonstrate a Si memristor with alloyed conduction channels that shows a stable and controllable device operation, which enables the large-scale implementation of crossbar arrays. The conduction channel is formed by conventional silver (Ag) as a primary mobile metal alloyed with silicidable copper (Cu) that stabilizes switching. In an optimal alloying ratio, Cu effectively regulates the Ag movement, which contributes to a substantial improvement in the spatial/temporal switching uniformity, a stable data retention over a large conductance range and a substantially enhanced programmed symmetry in analogue conductance states. This alloyed memristor allows the fabrication of large-scale crossbar arrays that feature a high device yield and accurate analogue programming capability. Thus, our discovery of an alloyed memristor is a key step paving the way beyond von Neumann computing.

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How did the universe evolve from a point of singularity, known as the Big Bang, into a massive structure whose boundaries seem limitless? New clues and insight into the evolution of the universe have recently been provided by an international team of physicists, who performed the most detailed large-scale simulation of the universe to date.

The researchers made their own universe in a box — a cube of space spanning more than 230 million light-years across. Previous cosmological simulations were either very detailed but spanned a small volume or less detailed across large volumes. The new simulation, known as TNG50, managed to combine the best of two worlds, producing a large-scale replica of the cosmos while, at the same time, allowing for unprecedented computational resolution.

Continue reading “Physicists perform the most detailed simulation of the Universe yet” »

Can lost species ever become un-extinct? Many scientists believe it’s only a matter of time before many extinct animals again walk the Earth through cloning.

A simple chemical reaction gives platelets the ability to swim around.

Numerous efforts have been made to improve the temporal resolution of CRISPR-Cas9–mediated DNA cleavage to the hour time scale. Liu et al. developed a Cas9 system that achieved genome-editing manipulation at the second time scale (see the Perspective by Medhi and Jasin). Part of the guide RNA is chemically caged, allowing the Cas9-guide RNA complex to bind at a specific genomic locus without cleavage until activation by light. This fast CRISPR system achieves genome editing at high temporal resolution, enabling the study of early molecular events of DNA repair processes. This system also has high spatial resolution at short time scales, allowing editing of one genomic allele while leaving the other unperturbed.

Science, this issue p. 1265; see also p. 1180

CRISPR-Cas systems provide versatile tools for programmable genome editing. Here, we developed a caged RNA strategy that allows Cas9 to bind DNA but not cleave until light-induced activation. This approach, referred to as very fast CRISPR (vfCRISPR), creates double-strand breaks (DSBs) at the submicrometer and second scales. Synchronized cleavage improved kinetic analysis of DNA repair, revealing that cells respond to Cas9-induced DSBs within minutes and can retain MRE11 after DNA ligation. Phosphorylation of H2AX after DNA damage propagated more than 100 kilobases per minute, reaching up to 30 megabases. Using single-cell fluorescence imaging, we characterized multiple cycles of 53BP1 repair foci formation and dissolution, with the first cycle taking longer than subsequent cycles and its duration modulated by inhibition of repair. Imaging-guided subcellular Cas9 activation further facilitated genomic manipulation with single-allele resolution.