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UC Merced researchers have found that the protein OTUD6 can alter protein production in cells, potentially affecting lifespan and cancer, with future research aimed at exploiting this for therapeutic benefits.

Researchers at UC Merced used fruit flies to uncover a cellular process shared by many organisms, which could significantly advance the understanding of cancer and aging.

Department of Molecular and Cell Biology Professor Fred Wolf, then-graduate student Sammy Villa, and Genentech Vice President and Senior Fellow in Physiological Chemistry and Research Biology Vishva Dixit, discovered a mechanism that cells use to tune how much protein they make through the process of translating RNA into protein.

Ten years ago, researchers succeeded in suppressing sound wave propagation in the backward direction; however, this also attenuated the waves traveling forwards.

A team of researchers at ETH Zurich led by Nicolas Noiray, professor for Combustion, Acoustics and Flow Physics, in collaboration with Romain Fleury at EPFL, has now developed a method for preventing sound waves from traveling backward without deteriorating their propagation in the forward direction.

In the future, this method, which has recently been published in Nature Communications, could also be applied to electromagnetic waves.

The the scientists developed can enable computational-based drug discovery to be used to target the i-motifs from the insulin gene, because when scientists know the specific 3D shape, they can design molecules digitally and model them to see whether they will fit.

Scientists can then develop new drugs using particular chemicals when they know which ones will fit the best—a process called rational design.

As the first crystal structure of this type, the researchers say it will also be useful as a model for other targets in the genome, besides the insulin gene, which form this shape of DNA.

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Dr. Wencai Zhang: “Our goal is to contribute to the supply chain of these critical materials while also making a positive environmental impact. We specifically aim to reduce the environmental consequences that can be associated with produced water.”


How can lithium, one of the most demanded minerals for clean energy products like electric vehicles, be harvested without harming the environment? This is | Technology.