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Telomerase is a ribonucleoprotein enzyme, which maintains genome integrity in eukaryotes and ensures continuous cellular proliferation. Telomerase holoenzyme from the thermotolerant yeast Hansenula polymorpha, in addition to the catalytic subunit (TERT) and telomerase RNA (TER), contains accessory proteins Est1 and Est3, which are essential for in vivo telomerase function. Here we report the high-resolution structure of Est3 from Hansenula polymorpha (HpEst3) in solution, as well as the characterization of its functional relationships with other components of telomerase. The overall structure of HpEst3 is similar to that of Est3 from Saccharomyces cerevisiae and human TPP1. We have shown that telomerase activity in H. polymorpha relies on both Est3 and Est1 proteins in a functionally symmetrical manner. The absence of either Est3 or Est1 prevents formation of a stable ribonucleoprotein complex, weakens binding of a second protein to TER, and decreases the amount of cellular TERT, presumably due to the destabilization of telomerase RNP. NMR probing has shown no direct in vitro interactions of free Est3 either with the N-terminal domain of TERT or with DNA or RNA fragments mimicking the probable telomerase environment. Our findings corroborate the idea that telomerase possesses the evolutionarily variable functionality within the conservative structural context.

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New experimental evidence of a collective behavior of electrons to form “quasiparticles” called “anyons” has been reported by a team of scientists at Purdue University.

Anyons have characteristics not seen in other , including exhibiting fractional charge and fractional statistics that maintain a “memory” of their interactions with other quasiparticles by inducing quantum mechanical phase changes.

Postdoctoral research associate James Nakamura, with assistance from research group members Shuang Liang and Geoffrey Gardner, made the discovery while working in the laboratory of professor Michael Manfra is a Distinguished Professor of Physics and Astronomy, Purdue’s Bill and Dee O’Brien Chair Professor of Physics and Astronomy, professor of electrical and computer engineering, and professor of materials engineering. Although this work might eventually turn out to be relevant to the development of a quantum computer, for now, Manfra said, it is to be considered an important step in understanding the physics of quasiparticles.

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Google has been placing COVID-19 reminders, warnings, and information in many of its services for some time now. You can’t use a Google service without being reminded to wear a mask, or of where to go for screening. It’s even added various tips to Maps, including where to get takeout during the pandemic. With a possible new overlay feature, it looks like we might soon be able to add Google Maps to our list of COVID tracing apps.

Jane Wong has shared screenshots she was able to trigger in Maps, showcasing the new feature. The pictures detail the COVID-19 tracking option alongside the other map overlays, like Traffic and Transit. The feature apparently sources data from Wikipedia, The New York Times, Johns Hopkins University, and Brihanmumbai Municipal Corporation. Using this information, the overlay colors impacted states, countries, and their borders. The map also displays whether the current numbers for each area are increasing or decreasing.

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DeepMind today announced a new milestone for its artificial intelligence agents trained to play the Blizzard Entertainment game StarCraft II. The Google-owned AI lab’s more sophisticated software, still called AlphaStar, is now grandmaster level in the real-time strategy game, capable of besting 99.8 percent of all human players in competition. The findings are to be published in a research paper in the scientific journal Nature.

Not only that, but DeepMind says it also evened the playing field when testing the new and improved AlphaStar against human opponents who opted into online competitions this past summer. For one, it trained AlphaStar to use all three of the game’s playable races, adding to the complexity of the game at the upper echelons of pro play. It also limited AlphaStar to only viewing the portion of the map a human would see and restricted the number of mouse clicks it could register to 22 non-duplicated actions every five seconds of play, to align it with standard human movement.

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“Eat your vitamins” might be replaced with “ingest your ceramic nano-particles” in the future as space research is giving more weight to the idea that nanoscopic particles could help protect cells from common causes of damage.

Oxidative stress occurs in our bodies when cells lose the natural balance of electrons in the molecules that we are made of. This is a common and constant occurrence that is part of our metabolism but also plays a role in the and several pathological conditions, such as heart failure, muscle atrophy and Parkinson’s disease.

The best advice for keeping your body in balance and avoiding oxidative stress is still to have a and eat enough vitamins, but nanoparticles are showing promising results in keeping cells in shape.

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Xanadu, a photonic quantum computing company, announced today the release of the world’s first publicly available photonic quantum cloud platform, according to a press release. Developers can now access Xanadu’s gate-based photonic quantum processors, in 8, 12, and soon 24-qubit machines.

Photonics based quantum computers have many advantages over older platforms. Xanadu’s quantum processors operate at room temperature. They can easily integrate into existing fiber optic-based telecommunication infrastructure, enabling a future where quantum computers are networked. It also offers great scalability supporting fault tolerance, owing to robust error-resistant physical qubits and flexibility in designing error correction codes. Xanadu’s unique type of qubit is based on squeezed states – a special type of light generated by our own chip-integrated silicon photonic devices.

“We believe that photonics offers the most viable approach towards universal fault-tolerant quantum computing with Xanadu’s ability to network a large number of quantum processors together. We are excited to provide this ecosystem, a world-first for both quantum and classical photonics,” said Christian Weedbrook, Xanadu Founder and CEO. “Our architecture is new, designed to scale-up like the Internet versus traditional mainframe-like approaches to quantum computing.”

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“Hotspots” of Coronavirus Infections in Human Bodies

An infection with the coronavirus SARS-CoV-2 can affect multiple organs. With this in mind, researchers of the German Center for Neurodegenerative Diseases (DZNE) and Cornell University in the US have investigated cellular factors that could be significant for an infection. To this end, they analyzed the activity of 28 specific genes in a wide range of human tissues. Their findings, which provide a map of potentially disease-relevant factors across the human body, are published in the journal Cell Reports.

“SARS-CoV-2 not just infects the respiratory system, it has the potential to affect many other organs in the body. Even if the virus infects the respiratory system first, it is essential to be able to predict where it might go next. This aids to develop therapies. Our goal was thus to learn more about what makes the different organs susceptible to infection,” explained Dr. Vikas Bansal, a data scientist at the DZNE’s Tuebingen site. “Therefore, we looked at different tissues to see which components of the cellular machinery might be relevant for infection and also which cell types appear to be particularly susceptible.” Bansal co-authored the current paper with Manvendra Singh, a Cornell presidential fellow, and with Cedric Feschotte, professor in the Department of Molecular Biology and Genetics at Cornell University.

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MIT’s Cheetah 3 robot can now leap and gallop across rough terrain, climb a staircase littered with debris, and quickly recover its balance when suddenly yanked or shoved, all while essentially blind.

Watch more videos from MIT: https://www.youtube.com/user/MITNewsOffice?sub_confirmation=1

The Massachusetts Institute of Technology is an independent, coeducational, privately endowed university in Cambridge, Massachusetts. Our mission is to advance knowledge; to educate students in science, engineering, and technology; and to tackle the most pressing problems facing the world today. We are a community of hands-on problem-solvers in love with fundamental science and eager to make the world a better place.
The MIT YouTube channel features videos about all types of MIT research, including the robot cheetah, LIGO, gravitational waves, mathematics, and bombardier beetles, as well as videos on origami, time capsules, and other aspects of life and culture on the MIT campus. Our goal is to open the doors of MIT and bring the Institute to the world through video.

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