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Blog – Page 7501

Defense advanced research projects agency — DARPA.

DARPA and the U.S. Air Force (USAF) today announced successful completion of captive carry tests of two variants of the Hypersonic Air-breathing Weapon Concept (HAWC) and are ready to proceed to first free-flight testing within the calendar year. The joint Agency and Service effort seeks to develop and demonstrate critical technologies to enable an effective and affordable air-launched hypersonic cruise missile.

HAWC performers Lockheed Martin and Raytheon Technologies have each tested advanced air vehicle configurations that promise to achieve and sustain efficient hypersonic flight. Their upcoming flight tests will focus on hydrocarbon scramjet-powered propulsion and thermal management techniques to enable prolonged hypersonic cruise, in addition to affordable system designs and manufacturing approaches.

“Completing the captive carry series of tests demonstrates both HAWC designs are ready for free flight,” said Andrew “Tippy” Knoedler, HAWC program manager in DARPA’s Tactical Technology Office. “These tests provide us a large measure of confidence – already well informed by years of simulation and wind tunnel work – that gives us faith the unique design path we embarked on will provide unmatched capability to U.S. forces.”

Continue reading “DARPA Completes Key Milestone on Hypersonics Air-breathing Weapons Program” | >

Ira Pastor, ideaXme life sciences ambassador, interviews Mr. Evgeni Borisov, CEO and Co-founder of Vimana Global Inc.

Ira Pastor Comments:

A flying car is a type of personal air vehicle, or “road able” aircraft, that provides door-to-door transportation by both ground and air, and was a popular theme in fantasy and science fiction stories throughout the early 20th century.

One of the first debuts of a flying car was that of Henry Ford, back in 1926, when he displayed an experimental single-seat airplane.

Continue reading “Vimana: From Mythical Flying Chariots to Space Age Vehicles” | >

Sleep has critical roles in health and regeneration, and one of those is clearing the brain of metabolic waste, according to researchers from the US and Denmark.

Now, as reported in the journal Nature Communications, they’ve discovered in mice that the time of day matters, suggesting the process is controlled by circadian rhythms.

“Our group has shown that just being awake or asleep drastically changes how well the brain can clear waste,” says lead author Lauren Hablitz from the University of Rochester Medical Centre.

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Groups of stars can tear their planet-forming disk to shreds, leaving behind warped, misaligned rings, scientists find in a breakthrough study.

Solar systems like ours generally form with their planets all orbiting in the same, flat plane. But, as an international team of scientists has found in a new study, this isn’t always the case.

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Please have a listen to Episode 14 of Cosmic Controversy with guest Julie Castillo, NASA’s Dawn mission project scientist. We spend much of the episode discussing the beguiling dwarf planet Ceres and the need for a sample return mission.

This week’s guest is NASA Dawn project scientist Julie Castillo-Rogez who led the hugely successful robotic mission on the first in-depth look at the asteroid Vesta and the dwarf planet Ceres. Castillo talks about why there’s a growing consensus that Ceres may have long had habitable subsurface conditions and why we need a sample return mission to launch in 2033. We also discuss Mars’ moons of Deimos and Phobos and the first interstellar asteroid, Oumuamua.

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Melittin (MEL), a major peptide component of bee venom, is an attractive candidate for cancer therapy. This agent has shown a variety of anti-cancer effects in preclinical cell culture and animal model systems. Despite a convincing efficacy data against variety of cancers, its applicability to humans has met with challenges due to several issues including its non-specific cytotoxicity, degradation and hemolytic activity. Several optimization approaches including utilization of nanoparticle based delivery of MEL have been utilized to circumvent the issues. Here, we summarize the current understanding of the anticancer effects of bee venom and MEL on different kinds of cancers. Further, we also present the available information for the possible mechanism of action of bee venom and/or MEL.

Keywords: Bee venom, Melittin, Melittin conjugates, Cancer management, Anti-cancer effects.

Cancer is one of the major ailment effecting humankind and remains as one of the leading causes of mortality worldwide. The current available data suggests that over 10 million new patients are diagnosed with the disease every year and over 6 million deaths are associated with it representing roughly 12% of worldwide deaths. Fifteen million new cancer cases are anticipated to be diagnosed in the year 2020 [1] which will potentially increase to over 20 million by 2025 [2] and more in years to come. It is also anticipated that the growth and aging of the population may increase the new cancer cases to 21.7 million with about 13 million cancer deaths by the year 2030 [3].

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