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Analysis revealed that variants in the HMGCR gene region, which represent proxies for statin treatment, were associated with overall cancer risk, suggesting that statins could lower overall cancer risk.

Cholesterol-lowering drugs called statins may reduce cancer risk in humans through a pathway unrelated to cholesterol, says a study published today in eLife.

Statins reduce levels of LDL-cholesterol, the so-called ‘bad’ cholesterol, by inhibiting an enzyme called HMG-CoA-reductase (HMGCR). Clinical trials have previously demonstrated convincing evidence that statins reduce the risk of heart attacks and other cardiovascular diseases. But evidence for the potential effect of statins to reduce the risk of is less clear.

“Previous laboratory studies have suggested that lipids including cholesterol play a role in the development of cancer, and that statins inhibit cancer development,” explains lead author Paul Carter, Cardiology Academic Clinical Fellow at the Department of Health and Primary Care, University of Cambridge, UK. “However, no trials have been designed to assess the role of statins for in clinical practice. We decided to assess the potential effect of therapy on cancer risk using evidence from human genetics.”

Continue reading “Statins may reduce cancer risk through mechanisms separate to cholesterol” | >

A collaboration between researchers from The University of Western Australia and The University of California Merced has provided a new way to measure tiny forces and use them to control objects.

The research, published recently in Nature Physics, was jointly led by Professor Michael Tobar, from UWA’s School of Physics, Mathematics and Computing and Chief Investigator at the Australian Research Council Centre of Excellence for Engineered Quantum Systems and Dr. Jacob Pate from the University of Merced.

Professor Tobar said that the result allowed a new way to manipulate and control macroscopic objects in a non-contacting way, allowing enhanced sensitivity without adding loss.

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A team of physicists led by Professor Patrick Windpassinger at Johannes Gutenberg University Mainz (JGU) has successfully transported light stored in a quantum memory over a distance of 1.2 millimeters. They have demonstrated that the controlled transport process and its dynamics has only little impact on the properties of the stored light. The researchers used ultra-cold rubidium-87 atoms as a storage medium for the light as to achieve a high level of storage efficiency and a long lifetime.

“We stored the light by putting it in a suitcase so to speak, only that in our case the suitcase was made of a cloud of cold atoms. We moved this suitcase over a short distance and then took the light out again. This is very interesting not only for physics in general, but also for , because light is not very easy to ‘capture’, and if you want to transport it elsewhere in a controlled manner, it usually ends up being lost,” said Professor Patrick Windpassinger, explaining the complicated process.

The controlled manipulation and storage of quantum information as well as the ability to retrieve it are essential prerequisites for achieving advances in quantum communication and for performing corresponding computer operations in the quantum world. Optical quantum memories, which allow for the storage and on-demand retrieval of quantum information carried by light, are essential for scalable quantum communication networks. For instance, they can represent important building blocks of quantum repeaters or tools in linear quantum computing. In recent years, ensembles of atoms have proven to be media well suited for storing and retrieving optical quantum information. Using a technique known as electromagnetically induced transparency (EIT), incident light pulses can be trapped and coherently mapped to create a collective excitation of the atoms. Since the process is largely reversible, the light can then be retrieved again with high efficiency.

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The planned launch of a private commercial airlock to the International Space Station in November will accelerate NASA’s plan to turn the station into a hub of private industry, space agency officials said.

The commercialization plan also includes the launch of a private habitat and laboratory by 2024 and a project NASA Administrator Jim Bridenstine announced on Twitter in May in which actor Tom Cruise will film a movie in space.

The 20-year-old space station may even have a private citizen on board again for the first time in years in late 2021, according to Phil McAlister, NASA’s director of commercial spaceflight. It’s part of a plan to wean the space station off NASA’s public funding of $3 billion to $4 billion per year.

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When it comes to vitamin D, most adults exhibit either frank deficiency, which results in clear clinical symptoms, or insufficiency, which often goes undetected. But how that insufficiency impacts physical health and the vulnerability of older adults to frailty as they age has been difficult to determine.

Now a University at Buffalo study of 24–28–month-old mice, the equivalent of 65-to-80-year-old adults, has found that can be slowed with what might be considered “over” supplementation with vitamin D, referred to as “hypersufficiency.”

Published Sept. 30 in Nutrients, the research builds on previous work that Kenneth L. Seldeen, Ph.D., first author and research assistant professor in the Department of Medicine in the Jacobs School of Medicine and Biomedical Sciences at UB, has been conducting for more than a decade with colleague Bruce R. Troen, MD, professor of medicine and chief of the Division of Geriatrics and Palliative Medicine and director of the Center for Successful Aging, both in the Jacobs School.

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Gets advanced, but some might like.

A research team from Cologne has discovered that a change in the DNA structure—more precisely in the chromatin—plays a decisive role in the recovery phase after DNA damage. The key is a double occupation by two methyl groups on the DNA packaging protein histone H3 (H3K4me2). The discovery was made by scientists under the direction of Prof. Björn Schumacher of the Cluster of Excellence for Aging Research CECAD, the Center for Molecular Medicine Cologne (CMMC), and the Institute for Genome Stability in Aging and Disease at the University of Cologne. The specific change enables genes to be reactivated and proteins to be produced after damage: The cells regain their balance and the organism recovers. The protective role of H3K4me2 was identified in experiments with the nematode Caenorhabditis elegans. The study has now been published in the journal Nature Structural & Molecular Biology.

The genome in every human cell is damaged on a daily basis, for example in the skin by UV radiation from the sun. Damage to the DNA causes diseases such as cancer, influences development, and accelerates aging. Congenital malfunctions in DNA repair can lead to extremely accelerated aging in rare hereditary diseases. Therefore, preservation and reconstruction processes are particularly important to ensure development and to maintain tissue function. DNA, which is rolled up on packaging proteins—the histones—like on cable drums, is regulated by methyl groups. Various proteins are responsible for placing methyl groups on histones or removing them. The number of groups on the packaging proteins affects the activity of genes and thus the production of the cell.

In experiments with the nematode, the research team showed that after repairing damaged DNA, two methyl groups were increasingly found on the DNA packages. Furthermore, they found that errors in placing these two methyl groups on the histones (H3K4me2) accelerated the damage-induced aging process, while increased position of this histone alteration prolongs the lifespan after DNA damage. By controlling the proteins that either set or remove these methyl groups, the resistance to DNA damage—and thus the aging process of the animals—could be influenced.

Continue reading “Research team discovers mechanism that restores cell function after genome damage” | >

My hero my love.

Last week, Tesla CEO Elon Musk made a rather interesting announcement for all-electric vehicle enthusiasts in India, when he mentioned that Tesla is planning on entering the Indian automobile market in 2021. The announcement comes after years of waiting for the Indians to get their hands on a Tesla, and it definitely has got the public buzzing with excitement. Now, Musk has also stated that Tesla will be coming up with a Booking Order Configurator for the Indian customers which will be going live in January 2021.

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Circa 2018

If you’ve been a grunt, then you probably have a love-hate relationship with body armor. You love having it in a firefight — it can save your life by stopping or slowing bullets and fragments — but you hate how heavy it is — it’s often around 25 pounds for the armor and outer tactical vest (more if you add the plate inserts to stop up to 7.62mm rounds). It’s bulky — and you really can’t move as well in it. In fact, in one firefight, a medic removed his body armor to reach wounded allies, earning a Distinguished Service Cross.

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