Lifeboat Foundation

The three-dimensional structure of the human genome is essential for providing a rapid and robust inflammatory response but is surprisingly not vital for reprogramming one cell type into another, according to research published today in Nature Genetics. The findings shed new light on the fundamental relationship between how a genome folds and the function of a cell.

Billionaire investor Ron Baron believes there’s still plenty of room for growth for Elon Musk’s Tesla and SpaceX companies.

Baron said Tuesday morning on “Squawk Box” that he believes “there’s 10 times more to go” with Tesla. He also said SpaceX, a privately held company, will grow by a multiple of 20 in the next 10 years. He previously predicted similar growth for Tesla.

3. Evolution shifts to off-world human colonies.

4. Transhumanism will drive evolution.

Is natural selection still a major force in human evolution? As far back as high school biology, we’ve been taught to think the answer must be yes. But is it really true?

Continue reading “Have humans reached the end of evolution? Not under these 4 scenarios” »

Is it possible to rapidly increase (or decrease) the amount of information the brain can store?

A new international study led by the Research Institute of the McGill University Health Centre (RI-MUHC) suggests it may be. Their research has identified a molecule that improves brain function and memory recall is improved. Published in the latest issue of Cell Reports, the study has implications for neurodevelopmental and neurodegenerative diseases, such as autism spectrum disorders and Alzheimer’s disease.

I remember questioning this data, as it was not even research on animals, it was observation of people’s medical files.

Three unlikely collaborators are at the heart of the fast-moving COVID-19 research scandal, which led to retractions last week by The Lancet and The New England Journal of Medicine (NEJM), and the withdrawal of an online preprint, after the trove of patient data they all relied on was challenged. The three physician-scientists never were at the same institution nor had they ever before written together, but they are the only authors in common on the disputed papers, and the other co-authors all have ties to at least one of them. Their partnership, which seized a high-impact role during a global public health crisis, has now ended disastrously.

The first author for both retracted papers was cardiac surgeon Mandeep Mehra, an eminent Harvard University professor who works at Brigham and Women’s Hospital (BWH) and is known internationally for cardiovascular medicine and heart transplants. He provided the kind of gravitas that can fast-track papers to leading journals. In a statement provided by BWH, Mehra said he had met another of the trio, cardiac surgeon Amit Patel, in “academic and medical circles,” and that Patel had introduced him to Sapan Desai, a vascular surgeon and founder of Surgisphere, the tiny company that supplied the data. Journal disclosures, however, also indicate Mehra received compensation from Triple-Gene, a gene therapy company Patel co-founded to develop cardiovascular treatments.

Continue reading “Who’s to blame? These three scientists are at the heart of the Surgisphere COVID-19 scandal” »

Another link on diet/healthspan.

Studies by Monash Biomedicine Discovery Institute (BDI), have provided a new understanding into the roles two essential amino acids play in metabolic health, which may help scientists in the fight against obesity.

Led by Dr. Adam Rose, the recent finding, published in Nature Communications, shows that by reducing the amount of two amino acids —threonine and tryptophan—in young healthy mice, they were able to burn more calories than they consumed, without calorie reduction, keeping them lean and healthy and without the side-effect of lower muscle mass. A low-threonine diet even protected mice that were morbidly obese and prone to developing type 2 diabetes.

Continue reading “Essential components of dietary restriction revealed” »

Paved roads are nice to look at, but they’re easily damaged and costly to repair. Erik Schlangen demos a new type of porous, asphalt made of simple materials with an astonishing feature: When cracked, it can be “healed” by induction heating. (Filmed at TEDxDelft.)

TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world’s leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design — plus science, business, global issues, the arts and much more.
Find closed captions and translated subtitles in many languages at http://www.ted.com/translate

Continue reading “Erik Schlangen: A ‘self-healing’ asphalt” »

A Minneapolis manufacturing company whose plant was set on fire by rioters plans to leave the city, saying that city officials afforded them no assistance in handling the destruction.

“They don’t care about my business,” 7-Sigma Inc.’s president and owner, Kris Wyrobek, told The Star Tribune about Minneapolis public officials. “They didn’t protect our people. We were all on our own.”

The 7-Sigma plant in south Minneapolis, which the company has maintained since 1987, shut down several hours early around 7 p.m. instead of 11 p.m. as a precautionary measure on the first night of rioting. The company manufactures several products, including rollers for high-speed printing presses and medical training mannequins.

The personal genomics and biotechnology company 23andMe is perhaps best known for its home DNA testing kits, whereby consumers can learn about their genetic make-up or ancestry.

However, after the COVID-19 outbreak was declared a global pandemic, the company switched gears and looked to see how their gene testing services could offer a helping hand in understanding the disease’s pathophysiology.

One aspect of COVID-19 that has puzzled scientists and clinicians alike is why, when infected with SARS-CoV-2, do some patients display mild to moderate symptoms (or no symptoms at all), whereas other patients develop severe symptoms that can prove fatal?