Lifeboat Foundation

From testing drugs to developing vaccines, the close study of the immune system is key to improving real-world health outcomes. T-cells are integral to this research, as these white blood cells help tailor the body’s immune response to specific pathogens.

With lattice light-sheet microscopy (LLSM), scientists have been able to closely examine individual cells, such as T-cells, in 4D. But with limited data points, there wasn’t an effective way to analyze the LLSM data.

A new paper by researchers from the Pritzker School of Molecular Engineering (PME) at the University of Chicago, published May 20 in the journal Cell Systems, introduces a solution—a pipeline for lattice light-sheet microscopy multi-dimensional analyses (LaMDA).

Strong coupling between cavity photon modes and donor/acceptor molecules can form polaritons (hybrid particles made of a photon strongly coupled to an electric dipole) to facilitate selective vibrational energy transfer between molecules in the liquid phase. The process is typically arduous and hampered by weak intermolecular forces. In a new report now published on Science, Bo Xiang, and a team of scientists in materials science, engineering and biochemistry at the University of California, San Diego, U.S., reported a state-of-the-art strategy to engineer strong light-matter coupling. Using pump-probe and two-dimensional (2-D) infrared spectroscopy, Xiang et al. found that strong coupling in the cavity mode enhanced the vibrational energy transfer of two solute molecules. The team increased the energy transfer by increasing the cavity lifetime, suggesting the energy transfer process to be a polaritonic process. This pathway on vibrational energy transfer will open new directions for applications in remote chemistry, vibration polariton condensation and sensing mechanisms.

Vibrational energy transfer (VET) is a universal process ranging from chemical catalysis to biological signal transduction and molecular recognition. Selective intermolecular vibrational energy transfer (VET) from solute-to-solute is relatively rare due to weak intermolecular forces. As a result, intermolecular VET is often unclear in the presence of intramolecular vibrational redistribution (IVR). In this work, Xiang et al. detailed a state-of-the-art method to engineer intermolecular vibrational interactions via strong light-matter coupling. To accomplish this, they inserted a highly concentrated molecular sample into an optical microcavity or placed it onto a plasmonic nanostructure. The confined electromagnetic modes in the setup then reversibly interacted with collective macroscopic molecular vibrational polarization for hybridized light-matter states known as vibrational polaritons.

Researchers at Seoul National University and Korea Advanced Institute of Science and Technology (KAIST) have recently developed a sensor that can act as an electronic skin and integrated it with a deep neural network. This deep learning-enhanced e-skin system, presented in a paper published in Nature Communications, can capture human dynamic motions, such as rapid finger movements, from a distance.

The new system stems from an interdisciplinary collaboration that involves experts in the fields of mechanical engineering and computer science. The two researchers who led the recent study are Seung Hwan Ko, a professor of mechanical engineering at Soul National University and Sungho Jo, a computing professor at KAIST.

For several years, Prof. Ko had been trying to develop highly sensitive strain sensors by generating cracks in metal nanoparticle films using laser technology. The resulting sensor arrays were then applied to a virtual reality (VR) glove designed to detect the movements of people’s fingers.

Microsoft announced Tuesday that it has built the fifth most powerful computer on Earth.

Packed with 285,000 processor cores and 10,000 GPUs, the supercomputer was built in collaboration with San Francisco-based artificial intelligence research organization OpenAI. Microsoft announced its partnership with OpenAI last year and contributed $1 billion to the project.

Continue reading “Microsoft OpenAI computer is world’s 5th most powerful” »

Buckling, the sudden loss of structural stability, is usually the stuff of engineering nightmares. Mechanical buckling means catastrophic failure for every structural system from rockets to soufflés. It’s what caused the Deepwater Horizon oil spill in 2010, among numerous other disasters.

But, as anyone who has ever played with a toy popper knows, buckling also releases a lot of energy. When the structure of a popper buckles, the energy released by the instability sends the toy flying through the air. Now, researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and Harvard’s Wyss Institute for Biologically Inspired Engineering have harnessed that energy and used buckling to their advantage to build a fast-moving, inflatable soft actuator.

Continue reading “Researchers build a fast-moving jumping soft robot” »

In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.

Malaria is a major infectious disease, caused by a parasite with a complicated life cycle in humans and mosquitoes. The first stage in humans takes place in the liver, the second in the blood. Since the liver phase does not cause any symptoms of disease, but the blood phase does, the purpose of the vaccine is to stop the parasite in the liver.

Tune in live at 4 p.m. EDT, as NASA astronauts Douglas Hurley and Robert Behnken arrive at Kennedy Space Center to meet the SpaceX #CrewDragon spacecraft and Falcon 9 rocket that will launch them to the space station and into history.

Airglow is the constant, faint glow of Earth’s upper atmosphere created by the interaction between sunlight and particles in this region. The phenomenon is similar to auroras, but where auroras are driven by high-energy particles originating from the solar wind, airglow is energized by ordinary, day-to-day solar radiation.

Studying airglow gives scientists clues about the upper atmosphere’s temperature, density, and composition, and helps us trace how particles move through the region itself. Two NASA missions take advantage of our planet’s natural glow to study the upper atmosphere: ICON focuses on how charged and neutral gases in the upper atmosphere interact, while GOLD observes what’s driving change — the Sun, Earth’s magnetic field or the lower atmosphere — in the region.

By watching and imaging airglow, the two missions enable scientists to tease out how Earth’s weather and space intersect, dictating the region’s complex behavior. https://go.nasa.gov/2RJax4x

Temporary tattoo electrodes are the most recent development in the field of cutaneous sensors. They have successfully demonstrated their performances in the monitoring of various electrophysiological signals on the skin. These epidermal electronic devices offer a conformal and imperceptible contact with the wearer while enabling good quality recordings over time. Evaluations of brain activity in clinical practice face multiple limitations, where such electrodes can provide realistic technological solutions and increase diagnostics efficiency. Here we present the performance of inkjet-printed conducting polymer tattoo electrodes in clinical electroencephalography and their compatibility with magnetoencephalography. The working mechanism of these dry sensors is investigated through the modeling of the skin/electrode impedance for better understanding of the biosignals transduction at this interface. Furthermore, a custom-made skin phantom platform demonstrates the feasibility of high-density recordings, which are essential in localizing neuropathological activities. These evaluations provide valuable input for the successful application of these ultrathin electronic tattoos sensors in multimodal brain monitoring and diagnosis.