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They Injected a Human With “Youth Genes” — Here’s What Actually Happened
The first human trial of a therapy designed to make older cells behave more like younger ones has begun. But did it reverse aging? No result has been reported yet.
In this video, Dr Deepa explains what was actually injected, why researchers started with only one eye, how ER-100 uses partial epigenetic reprogramming, and what this Phase 1 trial is really designed to discover.
We also examine a separate Klotho gene therapy being promoted through overseas clinics. What evidence supports it? Why don’t promising animal studies prove that people will live longer? And what risks should anyone understand before considering an experimental anti-aging treatment?
Covered in this video:
• ER-100 and partial epigenetic reprogramming.
• OSK and the Yamanaka factors.
• Why the treatment was injected into one eye.
• The doxycycline activation system.
• What researchers are monitoring for five years.
• Klotho and Minicircle gene therapy.
• Regulated trials versus treatments offered overseas.
• Tumour, immune and manufacturing risks.
• Questions to ask before considering experimental treatment.
The first participant was dosed in a Phase 1 study involving ER-100 for open-angle glaucoma and NAION. The primary purpose is to evaluate safety and tolerability—not to prove that human aging has been reversed.
#reverseaging #genetherapy #longevity.
NASA’s IXPE May Have Proven 90-Year-Old Theory
Scientists using NASA’s IXPE (Imaging X-ray Polarimetry Explorer) conducted more than 140 hours of observations of the magnetar 1E 1547–5408 between March and April 2025 alongside NASA’s NICER (Neutron Star Interior Composition Explorer) and Murriyang, CSIRO’s Parkes radio telescope, owned and operated by Australia’s national science agency. This was the first-ever coordinated radio and X-ray polarization measurement of a magnetar.
1E 1547–5408, spinning in a full rotation every 2 seconds, is a unique magnetar that consistently emits bright radio energy and X-ray light, for reasons scientists are still trying to understand.
Observations showed the polarization, or the orientation and level of alignment of the incoming photons, is nearly three times greater than seen in similar sources. This high level of polarization was surprising, since the geometry of the magnetar’s magnetic fields suggest that the measurements we see should be close to zero at certain points in the star. Standard surface emission models do not explain this large value either, indicating that another effect must be boosting the polarization.
Tracking And Trying To Optimize Oxidative Stress Biomarkers
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Researchers Map the Hidden 3D Geometry of a Quantum Wavefunction
Physicists at Göttingen University imaged three-dimensional wave functions using a tabletop soft X-ray laser.
An electron inside a molecule does not occupy one fixed point. Quantum mechanics instead describes it through a “wavefunction,” a mathematical map that gives the probabilities of properties such as position and momentum.
Within molecules, these electron wavefunctions are known as “molecular orbitals.” Their shapes contain information about how a molecule may absorb light, interact with its surroundings, or undergo a chemical reaction.
Starvationinduced phosphorylation activates gasdermin A to initiate pyroptosis
(Cell Reports 43, 114728; September 24, 2024)
Figure S4K was inadvertently assembled with the top image coming from that in Figure S4J, an error that occurred during the process of figure assembly. The legend to Figure S4K was also missing. Although the paper cannot be updated directly because of the amount of time that has passed since its original publication, the revised panel and its corresponding legend can be seen below.
This error and the correction thereof do not affect the conclusions of the article. The authors apologize for any confusion that may have been caused.
Just as sailboats are powered by the wind, space scientists and engineers dream of a day when spacecraft can be powered by solar sails
How would this work? The Sun blasts out radiation all the time. Radiation that strikes a large, shiny, sail-like structure would push on it, much as the wind pushes on a sailboat. Although the push would be very gentle, it would be constant. Over time, the spacecraft would be going very, very fast, using no fuel at all!
You may have heard of the “solar wind.” Solar wind is made of particles blasted out from the Sun. Solar sails do not “catch the solar wind.” Instead, solar sails use the force of the light itself. This force is much stronger than the force from the solar wind.
The Next Generation of CRISPR Has Arrived | Dr. Trevor Martin — CEO, Mammoth Biosciences
Dr. Trevor Martin, Ph.D. — Co-Founder & CEO, Mammoth Biosciences
Most of us think of medicine as something we take every day — a statin, a blood pressure pill, or perhaps a monthly injection. But what if those lifelong treatments eventually become obsolete? What if one carefully targeted gene edit could dramatically reduce your risk of heart disease for decades?
Dr. Trevor Martin, Ph.D. is the Co-Founder and Chief Executive Officer of Mammoth Biosciences (https://mammoth.bio/), a pioneering biotechnology company developing next-generation CRISPR genome editing technologies for potentially curative medicines. He co-founded the company in 2017 alongside Nobel Prize-winning CRISPR pioneer Dr. Jennifer Doudna and an interdisciplinary team of leading scientists with the goal of building more precise, versatile, and clinically practical gene editing systems.
Dr. Martin earned his undergraduate degree in Molecular Biology with honors from Princeton University before completing a Ph.D. in Genetics and Statistics at Stanford University, where his research focused on quantitative genetics, genomics, and computational biology. His scientific background in statistics and genetics has shaped Mammoth’s unique approach to developing smaller CRISPR enzymes capable of reaching tissues and diseases that have been difficult to target with first-generation technologies.
Under Dr. Martin’s leadership, Mammoth has grown into one of the world’s leading CRISPR companies, raising more than $465 million, achieving a valuation exceeding $1 billion, and establishing strategic collaborations with companies including Vertex Pharmaceuticals, Bayer, and Regeneron Pharmaceuticals.