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FDA Okays AI-Based Prostate Cancer Risk-Stratification Tool

The US FDA has granted De Novo marketing authorization for ArteraAI Prostate (Artera, Los Altos, California), a novel artificial intelligence (AI)-powered risk-stratification tool for patients with nonmetastatic prostate cancer.

The authorization means the digital pathology software tool is recognized as an FDA-regulated Software as a Medical Device, Artera explained in a press release.

De Novo authorization provides a marketing pathway to classify low-or moderate-risk novel medical devices. The De Novo authorization for this specific test establishes a new product code category for future AI-powered digital pathology risk-stratification tools and enables implementation at the point of diagnosis at qualified US pathology labs, the company said.

The test analyzes digital pathology images from patients’ biopsy slides to predict long-term outcomes, such as 10-year risk for metastasis and mortality. This can help direct treatment decisions.

The FDA’s De Novo authorization for the tool establishes a new product code category for future AI-powered digital pathology risk-stratification tools.

ChatGPT in Your Clinic: Who’s the Expert Now

Patients arriving at appointments with researched information is not new, but artificial intelligence (AI) tools such as ChatGPT are changing the dynamics.

Their confident presentation can leave physicians feeling that their expertise is challenged. Kumara Raja Sundar, MD, a family medicine physician at Kaiser Permanente Burien Medical Center in Burien, Washington, highlighted this trend in a recent article published in JAMA.

A patient visited Sundar’s clinic reporting dizziness and described her symptoms with unusual precision: “It’s not vertigo, but more like a presyncope feeling.” She then suggested that the tilt table test might be useful for diagnosis.

Occasionally, patient questions reveal subtle familiarity with medical jargon. This may indicate that they either have relevant training or have studied the subject extensively.

(Artificial Intelligence is the science of making machines do things that would require intelligence if done by men — Marvin Minsky. Google helps you gain information with a search engine. AI helps you gain information through algorithms. It is the same thing. However people profit from ignorance).

Patients are showing up with ChatGPT-generated diagnoses, challenging physicians to balance empathy, evidence, and authority in the exam room.

Continue reading “ChatGPT in Your Clinic: Who’s the Expert Now” | >

Bioengineering and Biotechnology Approaches in Cardiovascular Sciences, Volume III

Prosthetic heart valves (PHV) have been studied for around 70 years. They are the best alternative to save the life of patients with cardiac valve diseases. However, current PHVs may still cause significant disadvantages to patients. In general, native heart valves show complex structures and reproducing their functions challenges scientists. Valve repair and replacement are the options to heal heart valve diseases (VHDs), such as stenosis and regurgitation, which show high morbidity and mortality worldwide. Valve repair contributes to the performance of cardiac cycles. However, it fails to restore valve anatomy to its normal condition. On the other hand, replacement is the only alternative to treat valve degeneration. It may do so by mechanical or bioprosthetic valves. Although prostheses may restructure patients’ cardiac cycle, both prostheses may show limitations and potential disadvantages, such as mechanical valves causing thrombogenicity or bioprosthetic valves, calcification. Thus, prostheses require constant improvements to remedy these limitations. Although the design of mechanical valve structures has improved, their raw materials cause great disadvantages, and alternatives for this problem remain scarce. Cardiac valve tissue engineering emerged 30 years ago and has improved over time, e.g., xenografts and fabricated heart valves serving as scaffolds for cell seeding. Thus, this review describes cardiac valve substitutes, starting with the history of valvular prosthesis transplants and ending with some perspectives to alleviate the limitations of artificial valves.

GRAPHICAL ABSTRACT

Tesla Kills Dojo for AI6! Here’s Why

Questions to inspire discussion.

🚗 Q: How will AI6 be used in Tesla vehicles? A: AI6 will be used for FSD inference, with two chips in every car, enabling advanced autonomous driving capabilities.

🤖 Q: What role will AI6 play in Optimus? A: AI6 will enable on-device learning and reinforced learning in Optimus, enhancing its AI capabilities.

🔋 Q: Will AI6 be used in other Tesla products? A: AI6 will be integrated into every edge device produced by Tesla, including Tesla Semi, Mega Pack, and security cameras.

Technical Specifications.

💻 Q: What is the architecture of AI6? A: AI6 will use a cluster model of individual chips with a software layer on top, similar to Dojo 3 for training.

Continue reading “Tesla Kills Dojo for AI6! Here’s Why” | >

IVAE: an interpretable representation learning framework enhances clustering performance for single-cell data

Variational autoencoders (VAEs) serve as essential components in large generative models for extracting latent representations and have gained widespread application in biological domains. Developing VAEs specifically tailored to the unique characteristics of biological data is crucial for advancing future large-scale biological models.

Through systematic monitoring of VAE training processes across 31 public single-cell datasets spanning oncological and normal conditions, we discovered that reducing the β β value which corresponds to lower disentanglement of VAE significantly improves unsupervised clustering metrics in single-cell data analysis. Based on this finding, we innovatively developed iVAE with an irecon module that, when benchmarked against 8 established dimensionality reduction methods across 5 clustering performance metrics, exhibited superior capabilities in representing single-cell transcriptomic data.

Scientists just proved a fundamental quantum rule for the first time

Scientists have, for the first time, experimentally proven that angular momentum is conserved even when a single photon splits into two, pushing quantum physics to its most fundamental limits. Using ultra-precise equipment, the team captured this elusive process—comparable to finding a needle in a haystack—confirming a cornerstone law of nature at the photon level.

Terra Quantum Brings Quantum Gravity to Quantum Computing: Advance Reduces Errors Without Added Complexity

Terra Quantum has published a groundbreaking advance in quantum error correction that redefines how we scale quantum computing. In the peer-reviewed paper “QMM-Enhanced Error Correction: Demonstrating Reversible Imprinting and Retrieval for Robust Quantum Computation”, Terra Quantum scientists present QMM-Enhanced Error Correction, a hardware-validated, measurement-free method for suppressing quantum errors, based on principles derived initially from quantum gravity.

At the heart of this innovation is the Quantum Memory Matrix (QMM), a cosmology-inspired concept that models space-time as a lattice of finite-dimensional memory cells. Terra Quantum has now translated this deep theoretical idea into a functional quantum circuit. Validated on IBM’s superconducting processors, the QMM layer functions as a lightweight, unitary “booster” that enhances fidelity without mid-circuit measurements or added two-qubit gates, offering a powerful alternative to traditional surface codes.

“We have taken a concept rooted in quantum gravity and made it plug-and-play for today’s quantum processors,” said Florian Neukart, Chief Product Officer at Terra Quantum. “QMM-enhanced error correction works out of the box on existing hardware, requires no architectural changes, and delivers measurable gains. For industries building quantum solutions now, not in 10 years. This is a game-changer.

Terra Quantum has introduced QMM-Enhanced Error Correction, a hardware-validated, measurement-free method that suppresses quantum errors.

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