Lifeboat Foundation

In mammals, the acquisition of the germline from the soma provides the germline with an essential challenge, the necessity to erase and reset genomic methylation¹. In the male germline, RNA-directed DNA methylation silences young active transposable elements (TEs)^2–4. The PIWI protein MIWI2 (PIWIL4) and its associated PIWI-interacting RNAs (piRNAs) instruct TE DNA methylation^3,5. piRNAs are proposed to tether MIWI2 to nascent TE transcripts; however, the mechanism by which MIWI2 directs de novo TE methylation is poorly understood but central to the immortality of the germline. Here we define the interactome of MIWI2 in foetal gonocytes that are undergoing de novo genome methylation and identify a novel MIWI2-associated factor, SPOCD1, that is essential for young TE methylation and silencing. The loss of Spocd1 in mice results in male-specific infertility but impacts neither piRNA biogenesis nor localization of MIWI2 to the nucleus. SPOCD1 is a nuclear protein and its expression is restricted to the period of de novo genome methylation. We found SPOCD1 co-purified in vivo with DNMT3L and DNMT3A, components of the de novo methylation machinery as well as constituents of the NURD and BAF chromatin remodelling complexes. We propose a model whereby tethering of MIWI2 to a nascent TE transcript recruits repressive chromatin remodelling activities and the de novo methylation apparatus through SPOCD1. In summary, we have identified a novel and essential executor of mammalian piRNA-directed DNA methylation.

An array of ring lasers provides the first continuous measurement of Earth’s motion from a single location.

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Objective To determine whether training with a brain–computer interface (BCI) to control an image of a phantom hand, which moves based on cortical currents estimated from magnetoencephalographic signals, reduces phantom limb pain.

Methods Twelve patients with chronic phantom limb pain of the upper limb due to amputation or brachial plexus root avulsion participated in a randomized single-blinded crossover trial. Patients were trained to move the virtual hand image controlled by the BCI with a real decoder, which was constructed to classify intact hand movements from motor cortical currents, by moving their phantom hands for 3 days (“real training”). Pain was evaluated using a visual analogue scale (VAS) before and after training, and at follow-up for an additional 16 days. As a control, patients engaged in the training with the same hand image controlled by randomly changing values (“random training”). The 2 trainings were randomly assigned to the patients. This trial is registered at UMIN-CTR (UMIN000013608).

Results VAS at day 4 was significantly reduced from the baseline after real training (mean [SD], 45.3 [24.2]–30.9 [20.6], 1/100 mm; p = 0.009 < 0.025), but not after random training (p = 0.047 0.025). Compared to VAS at day 1, VAS at days 4 and 8 was significantly reduced by 32% and 36%, respectively, after real training and was significantly lower than VAS after random training (p < 0.01).

The $5 billion XpressWest project will connect Southern California to Las Vegas with electric trains traveling up to 200 miles an hour.

Three professors at the University of Southampton school of medicine have this week made a “major breakthrough” in the treatment of coronavirus patients and become paper millionaires at the same time.

Almost two decades ago professors Ratko Djukanovic, Stephen Holgate and Donna Davies discovered that people with asthma and chronic lung disease lacked a protein called interferon beta, which helps fight off the common cold. They worked out that patients’ defences against viral infection could be boosted if the missing protein were replaced.

The academics created a company, Synairgen, to turn their discoveries into treatments. It floated on the stock market in 2004, but a deal with AstraZeneca to treat viral infections in asthmatics fell through, and the shares collapsed.

Note: This article was originally published on May 29, 2017, and updated on July 24, 2020 Overview Neural Networks is one of the most popular machine learning algorithms Gradient Descent forms the basis of Neural networks Neural networks can be implemented in both R and Python using certain libraries and packages.

Some users of Nest thermostats can no longer control the devices remotely, and the issue is forcing Google to replace the devices entirely if otherwise standard troubleshooting fails. The issue, which began popping up on Nest forums as early as last November and racking up more than 200 responses, is known as the “w5 error,” and it disables remote control of the company’s thermostats.

Controlling the temperature of your home with your smartphone when you’re out of the house or away from the physical device is pretty much the sole selling point of the Nest thermostat. So that makes this a pretty serious issue, even if you still can manually adjust the temperature on the device itself. Google says it’s aware of the problem and that it’s now offering replacements to owners of the device who cannot solve the issue through standard reset procedures.

“A very small number of Nest thermostat users are experiencing a known issue with the Wi-Fi chip that causes remote connectivity issues. This does not affect the thermostat’s ability to control the customer’s heating and cooling system in the home, but does impact the user’s ability to manage the thermostat remotely,” a Google spokesperson tells The Verge. “If a user sees this error and it can’t be resolved through troubleshooting, they are prompted to contact customer support for assistance and will be issued a replacement device.”

The incredibly rare family portrait highlights two baby exoplanets orbiting a very young, sun-like star.

I am for ethical Ai. What about you?

Sophia interviews Stanford AI Researcher Tina White about how A.I. & Robotics can help stop the spread of Covid19 through contact tracing while preserving users’ privacy.

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