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In a review published in the journal *Science*, Jain and Steele Laboratories colleagues Hadi T. Nia, PhD, and Lance L. Munn, PhD, describe four distinct physical hallmarks of cancer that affect both cancer cells and the tumor microenvironment, contributing to both tumor growth and the development of resistance to powerful cancer drugs.

One widely accepted model of cancer holds that a normal cell goes rogue because of genetic mutations or an environmental insult. In this model, the altered cell starts replicating out of control and takes over normal tissues, displaying eight hallmarks that include the ability to promote and sustain the growth of tumors, evade immune system attempts to suppress growth, stimulate blood flow to tumors and both invade local tissues and metastasize (spread) elsewhere in the body.

But this model fails to take into account how physical processes affect tumor progression and treatment, say the authors. In addition to the aforementioned eight biological hallmarks of cancer proposed by Robert Weinberg, PhD, from MIT, and Douglas Hanahan, PhD, from the Swiss Federal Institute of Technology in Lausanne, Jain and colleagues propose adding four distinct physical hallmarks that capture the biomechanical abnormalities in tumors: elevated solid stress; elevated interstitial fluid pressure; increased stiffness and altered material properties; and altered tissue micro-architecture.

Three decades of research in the Steele Laboratories led to the discovery and clinical translation of the first two hallmarks. “Solid stresses are created as proliferating and migrating cells push and stretch solid components of the surrounding tissue. They are large enough to compress blood and lymphatic vessels in and around tumors, impairing blood flow and the delivery of oxygen, drugs and immune cells,” Jain says.

Elevated interstitial fluid pressure is caused by abnormally permeable blood vessels in tumors leaking blood plasma into tissues surrounding the tumor, and by insufficient drainage of lymphatic fluid. The interstitial fluid carries various growth factors with it, causing edema (swelling), elution (release) of drugs and growth factors, and facilitating cancer invasion of local and distant tissues.

Video from Waste-Ed. So basically, when we wash our clothes we release microplastics into the environment. The plastics come from fibers in our clothes.

They’ve added a filter to the washing machine to collect these microplastics to prevent these from spreading.


Dirt isn’t the only thing getting washed down the drain when you do laundry! Before your clothes make it to the dryer, tiny microfibers break off in the wash and travel through wastewater to pollute our… More environment. That changes with this microplastics filter that stops pollution at the source! Just install it on the side of the washer and send it back for safe disposal after it’s full. It captures 90% of the fibers that contaminate our planet!

R-sharing. Hmmm… would you trust the AI to drive for you?


At the end of November, Tesla (NASDAQ: TSLA) released its Vehicle Safety Report for Q3 2020, which shows that its vehicles using Autopilot are almost 10 times safer than other vehicles on United States roads. While the California manufacturer has directed massive efforts towards achieving Level 5 autonomy, the development of autonomous driving in Europe is at best slow-moving.

Recently, though, researchers in Germany are suggesting that this should change, and for good reason. The researchers indicate that, if Tesla Autopilot were installed on all cars in the Germany now, they would be able to avoid hundreds of thousands of car accidents.

“Legislative procedures that provide legal support for autonomous driving are progressing slowly,” criticizes Ferdinand Dudenhöffer, director of the Center for Automotive Research (CAR) in Duisburg.

If you are interested in developing chatbots, you can find out that there are a lot of powerful bot development frameworks, tools, and platforms that can use to implement intelligent chatbot solutions. How about developing a simple, intelligent chatbot from scratch using deep learning rather than using any bot development framework or any other platform. In this tutorial, you can learn how to develop an end-to-end domain-specific intelligent chatbot solution using deep learning with Keras.

In this interview to Allison Duettmann, Carolina Reis, OneSkin’s CEO, describes the results of the prove of concept clinical study that the company performed for the product launched in the market some weeks ago, and explains more thoroughly the possible mechanisms of action involved in the reduction of senescent cells in the skin.


Zoom Transcription: https://otter.ai/s/DxPPE-AMSl6VdZa4K8dkDQ

To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.

Researchers at the Department of Energy’s Oak Ridge National Laboratory used neutron scattering to identify key information to improve the effectiveness of drug inhibitors designed to block the virus’s replication mechanism. The research is published in the Journal of Biological Chemistry.

The SARS-CoV-2 virus, which causes the COVID-19 disease, expresses long chains of proteins composed of approximately 1,900 amino acid residues. For the virus to reproduce, those chains have to be broken down and cut into smaller strands by an enzyme called the main protease. The active protease enzyme is formed from two identical protein molecules held together by hydrogen bonds. Developing a drug that inhibits or blocks the protease activity will prevent the virus from replicating and spreading to other cells in the body.