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Investing in the convergence of bioelectrics & biologics for regeneration & healing — howard J. leonhardt, founder, leonhardt ventures.

Howard Leonhardt is the Founder of Leonhardt Ventures, the world’s first Innovation Accelerator focused on the convergence of bioelectrics & biologics for organ regeneration and tissue healing.

Howard is an accomplished inventor and serial entrepreneur, with 21 U.S. patents, over 100 patent claims for products for treating cardiovascular disease, and has over 40 new patent claims pending. His TALENT (Taheri-Leonhardt) stent graft, developed in the early 1990′s, holds a leading world market share for repairing aortic aneurysms without surgery.

Howard’s inventions to date have been involved in treated over 500000 patients in 60 countries.

Howard is co-leader of Startup California and Founder and Chairman of The California Stock Exchange TM (Cal-X) preparing to be the first social good impact stock exchange currently operating the Cal-X 30 Social Good Impact fund. He founded Cal-X Crowdfund Connect, a crowdfunding campaign management company, and Cal-X Stars Business Accelerator, Inc., a business incubator and accelerator focused on cardiovascular life sciences and social good impact innovations.

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NAD Coenzymes, Metabolic Stress, And Novel Preventative And Therapeutic Interventions — Dr. Charles Brenner, Ph.D., City of Hope.

Dr. Charles Brenner Ph.D. is the Alfred E Mann Family Foundation Chair in Diabetes and Cancer Metabolism, and Professor and Chair of the Department of Diabetes & Cancer Metabolism, at the City of Hope Comprehensive Cancer Center (https://www.cityofhope.org/faculty/charles-brenner).

With his Ph.D. in Cancer Biology from Stanford University, Dr. Brenner’s laboratory focuses on disturbances in nicotinamide adenine dinucleotide (NAD), the central catalyst of metabolism, in diseases and conditions of metabolic stress (https://www.cityofhope.org/charles-brenner-lab).

Among his most significant discoveries, Dr. Brenner identified nicotinamide riboside (NR) as a vitamin precursor of NAD, as well as a quantitative metabolomic technology that allowed him to discover that the NAD system is disturbed by many diseases and conditions of metabolic stress, including diabetes and cancer.

Specifically, Dr. Brenner and colleagues have found that in animal models of fatty liver, type 2 diabetes, diabetic and chemotherapeutic neuropathy, central brain injury, heart failure, postpartum and coronavirus infection, the NAD system is disturbed and that in these models, provision of nicotinamide riboside is highly protective.

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Health Innovation Investment For The Future Generations — Dr. Aboubacar Kampo, MD, MPH — Director of Health Programs — UNICEF.

Dr. Aboubacar Kampo, MD, MPH is the Director of Health Programs at UNICEF (UN Headquarters) where he provides strategic leadership, management support and overall direction to UNICEF’s global health program.

UNICEF, also known as the United Nations Children’s Emergency Fund, is a United Nations agency responsible for providing humanitarian and developmental aid to children worldwide. The agency is among the most widespread and recognizable social welfare organizations in the world, with a presence in 192 countries and territories. UNICEF’s activities include providing immunizations and disease prevention, administering treatment for children and mothers with HIV, enhancing childhood and maternal nutrition, improving sanitation, promoting education, and providing emergency relief in response to disasters.

With over 20 years of experience in development aid and humanitarian assistance, Dr. Kampo has worked as a physician/surgeon in hospitals and clinics in rural and urban areas in Africa and Asia and has over 14 years’ experience in senior management position as Country Director, Senior Global Health Advisor, and Chief of Health and Nutrition with International NGOs and United Nations’ Agencies.

Dr. Kampo is a Medical Doctor and Public Health Specialist, passionate about using innovations to address real life community challenges and bridge the gap between communities and stakeholders.

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From 3 day weekends to a future where all the jobs you do not want to do are automated, leaving you to spend your time as you desire.
Learning and research.
Sport and recreation.
Tourism and adventure.
Or whatever takes your fancy…

Well 4 day working weeks are already arriving, and I then show the rate of break throughs in Artificial Intelligence in just the last decade, which are removing the repetition and boredom from our jobs, so we can spend more time on the bits that matter and that are of interest.

What do you think?

Let us know your thoughts in the comments.

If you want to see more about the decade of disruption that is heading our way, then check out this next…

Iceland study.

Continue reading “From 3 Day Weekends Through To A Life Of Leisure. The Future Is Looking Good” | >

We have a much better understanding of physics than we do of consciousness. I consider ways in which intrinsically mental aspects of fundamental ontology might induce modifications of the known laws of physics, or whether they could be relevant to accounting for consciousness if no such modifications exist. I suggest that our current knowledge of physics should make us skeptical of hypothetical modifications of the known rules, and that without such modifications it’s hard to imagine how intrinsically mental aspects could play a useful explanatory role. Draft version of a paper submitted to Journal of Consciousness Studies, special issue responding to Philip Goff’s Galileo’s Error: Foundations for a New Science of Consciousness.

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“There was cheering in the control center” when word came that NASA had brought a key computer back, says James Jeletic, the Hubble project’s deputy project manager.

The Hubble Space Telescope is returning to operation more than a month after its original payload computer shut down. NASA said it has successfully switched over to its backup computer — and while the process of bringing the system back online is slow, the agency has started to bring science instruments out of “safe mode.”

“There was cheering in the control center” on Thursday night when word came that NASA had managed to restore the payload computer, James Jeletic, Hubble’s deputy project manager, told NPR.

“There’s a big sense of relief,” Jeletic said.

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A star in a distant galaxy blew up in a powerful explosion, solving an astronomical mystery.

Dr. Iair Arcavi, a Tel Aviv University researcher at the Raymond and Beverly Sackler Faculty of Exact Sciences, participated in a study that discovered a new type of stellar explosion — an electron-capture supernova. While they have been theorized for 40 years, real-world examples have been elusive. Such supernovas arise from the explosions of stars 8–9 times the mass of the sun. The discovery also sheds new light on the thousand-year mystery of the supernova from A.D. 1054 that was seen by ancient astronomers, before eventually becoming the Crab Nebula, that we know today.

A supernova is the explosion of a star following a sudden imbalance between two opposing forces that shaped the star throughout its life. Gravity tries to contract every star. Our sun, for example, counter balances this force through nuclear fusion in its core, which produces pressure that opposes the gravitational pull. As long as there is enough nuclear fusion, gravity will not be able to collapse the star. However, eventually, nuclear fusion will stop, just like gas runs out in a car, and the star will collapse. For stars like the sun, the collapsed core is called a white dwarf. This material in white dwarfs is so dense that quantum forces between electrons prevent further collapse.

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Most of the tests that doctors use to diagnose cancer — such as mammography, colonoscopy, and CT scans — are based on imaging. More recently, researchers have also developed molecular diagnostics that can detect specific cancer-associated molecules that circulate in bodily fluids like blood or urine.

MIT engineers have now created a new diagnostic nanoparticle that combines both of these features: It can reveal the presence of cancerous proteins through a urine test, and it functions as an imaging agent, pinpointing the tumor location. In principle, this diagnostic could be used to detect cancer anywhere in the body, including tumors that have metastasized from their original locations.

“This is a really broad sensor intended to respond to both primary tumors and their metastases. It can trigger a urinary signal and also allow us to visualize where the tumors are,” says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science at MIT and a member of MIT’s Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science.

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