Lifeboat Foundation

Scientists hope the CRISPR-based therapy could treat neurodegenerative disease.

Scientists investigating Alzheimer’s treatments at the Salk Institute have uncovered some key mechanisms that enable an experimental drug to reverse memory loss in mouse models of the disease. The discovery not only bodes well for the possibility of clinical trials, but provides researchers with a new target to consider in the wider development of compounds to counter the degenerative effects of the condition.

The research centers on a drug called CMS121, which is a synthetic version of a chemical called fisetin that occurs naturally in fruits and vegetables. The Salk team’s previous studies concerning CMS121 have produced some very promising results, with one paper published last year describing how the drug influences age-related metabolic pathways in the brain, protecting against the type of degeneration associated with Alzheimer’s. This followed earlier studies demonstrating how fisetin can prevent memory loss in mice engineered to develop Alzheimer’s.

Work continues at Salk to understand how exactly fisetin and the synthetic variant CMS121 produces these anti-aging effects on the brain. In their latest study, the researchers again turned to mice engineered to develop Alzheimer’s, which were administered daily doses of CMS121 from the age of nine months. This is the equivalent to middle age in humans, with the mice already exhibiting learning and memory problems before the treatment began.

100% vegan footwear.

Circa 2016 bigsmile

Artist Phil Ross introduces leather made from mycelium as a more eco-friendly replacement for animal leather.

Google has announced a new technology, powered by an acquisition called Socratic, that will let students take photos of their math homework in order to get the solutions. Google says it wants the Lens-powered technology to help parents and caretakers who are homeschooling, likely for the first time, as a result of the global COVID-19 pandemic.

Circa 2018

Bolt Threads–which also makes synthetic spider silk to use in clothes–is debuting a handbag made from mycelium, the root structure of mushrooms.

[Photo: Bolt Threads]

Bay Area based artist-inventor and amateur mycologist Phil Ross has an international patent pending on a method of producing fungus as a sustainable construction material. It may be surprising to hear that a biodegradable, durable, and non-toxic building material is on sale in the vegetable aisle at the supermarket. However, it’s not the tasty caps that Ross is after, but the root-like fibers of mushrooms form an enormous underground tangle called mycelium. Dried mycelium forms a lightweight mold and water resistant fire-proof material that is an effective insulator. It is also very sturdy stuff. Bob Engels of Gourmet Mushrooms notes, “Hardened steel blades on equipment at our farm need regular attention following their encounters with these massed threads of hyphae.”

Ross reported that multiple saw blades and metal files were destroyed while shaping the five hundred mycelium bricks he grew into an archway. The archway was a 6×6 foot sculpture titled Mycotectural Alpha, and was likely the first man-made structure made entirely out of mushrooms. Others have taken notice of the potential of fungus—a new start-up called Evocative Design producing mycelium alternatives to styrofoam and insulation material has received grants from the National Science Foundation, the Environmental Protection Agency, and the Department of Agriculture.

Ross’s “biotechnical” artwork encompasses drawings, paintings, sculptures, prototypes, and extensive materials research. Over the past 15 years he has been experimenting with fungus, growing and shaping mushrooms in sterile laboratory-like environments, even learning to make his own air filters to provide the necessary clean air. He says mycelium bricks can be grown in about a week from a mixture poured into a mold, but the more organic-looking mushroom sculptures that are created by adding or subtracting gas or air from their growing environment can take years to create. the artist explains how the “myotecture” bricks are made:

Bacteria that can help defuse highly toxic dioxin in sediments in the Passaic River—a Superfund hazardous waste site—could eventually aid cleanup efforts at other dioxin-contaminated sites around the world, according to Rutgers scientists.

Their research, published in the journal Environmental Science & Technology, needs further work to realize the full potential of the beneficial bottom-dwelling microbes.

“The bacteria-driven process we observed greatly decreases the toxicity of dioxin,” said senior author Donna E. Fennell, a professor who chairs the Department of Environmental Sciences in the School of Environmental and Biological Sciences at Rutgers University–New Brunswick.

Circa 2015

Solar power plants in Qatar and Jordan, not far from the sea, are powering desalination systems that irrigate plants in and around greenhouses.