Lifeboat Foundation

Summary: Researchers explore the close relationship between depression and pain. For some people, unexplained symptoms of pain, such as back or headaches, could be an early indicator of depression before mood changes occur.

Source: Mayo Clinic

Pain and depression are closely related. Depression can cause pain – and pain can cause depression. Sometimes pain and depression create a vicious cycle in which pain worsens symptoms of depression, and then the resulting depression worsens feelings of pain.

Humans are not the only species facing a potential threat from SARS-CoV-2, the novel coronavirus that causes COVID-19, according to a new study from the University of California, Davis.

An international team of scientists used genomic analysis to compare the main cellular receptor for the virus in humans—angiotensin converting enzyme-2, or ACE2—in 410 different species of vertebrates, including birds, fish, amphibians, reptiles and mammals.

ACE2 is normally found on many different types of cells and tissues, including epithelial cells in the nose, mouth and lungs. In humans, 25 amino acids of the ACE2 protein are important for the virus to bind and gain entry into cells.

An artificial intelligence algorithm by Heron Systems defeated an F-16 pilot in a simulated dogfight competition Thursday. Photo by SSgt. Christine Groening/U.S. Air force.

The Crew Dragon capsule that will launch the Crew-1 flight to the International Space Station this fall arrived in Florida on Tuesday (Aug. 18).

Ahead of a likely ban on the US federal government’s use of Chinese-made quadcopters, including popular DJI drones, the Department of Defense has approved the products of five US-based unmanned air vehicle (UAV) makers for government use.

Those companies are Altavian, Parrot, Skydio, Teal and Vantage Robotics.

Small UAVs from these manufacturers have been deemed cyber-secure by the Pentagon – not vulnerable to backdoor spying that some suspect might be possible from the video cameras and other sensors attached to Chinese-made DJI drones. The US Congress is considering banning the US federal government from using foreign-made drones as part of its 2021 National Defense Authorization Act.

After a decade of heated debate, free-flying swarms aimed at shrinking dengue-carrying mosquito populations gets a nod for 2021 in the Florida Keys.

We always wonder how that “Eureka Moment” turns up…but truth may lie in the “High and Mighty”.

Cracked.com’s new book is now on sale. What follows is one of the classic articles that appear in the book, along with 18 new articles that you can’t read anywhere else.

Any dreadlocked white guys finding this article after Googling “Drugs Rule” should know that we’ve given this list about drugs a rule. To make the cut, an accomplishment has to be considered great by people who could pass a field sobriety test. So no Grateful Dead music. We’re sure someone somewhere has enjoyed the Dead perfectly sober, just as there are probably non-Christians who listen to Christian Rock. But we’re just as sure that in the grand scheme of things, those people don’t count.

Continue reading “The 5 Greatest Things Ever Accomplished While High” »

Metabolic plasticity allows cancer cells to adjust their metabolic phenotypes to adapt in hostile environments. There is an urgent need to understand the cross-talk between gene regulation and metabolic pathways underlying cancer metabolic plasticity. We establish a theoretical framework to decode the coupling of gene regulation and metabolic pathways. Our work characterizes a hybrid metabolic state where cells can use both glycolysis and oxidative phosphorylation (OXPHOS) and a possible metabolically inactive state where cells have low activity of both glycolysis and OXPHOS. We show that targeting both OXPHOS and glycolysis may be necessary to eliminate cancer aggressiveness. Our work serves as a platform to target abnormal metabolism in cancer by modulating both genes and metabolic pathways.

Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis and metastasis. However, it is still largely unknown how cancer cells orchestrate gene regulation to balance their glycolysis and OXPHOS activities. Previously, by modeling the gene regulation of cancer metabolism we have reported that cancer cells can acquire a stable hybrid metabolic state in which both glycolysis and OXPHOS can be used. Here, to comprehensively characterize cancer metabolic activity, we establish a theoretical framework by coupling gene regulation with metabolic pathways. Our modeling results demonstrate a direct association between the activities of AMPK and HIF-1, master regulators of OXPHOS and glycolysis, respectively, with the activities of three major metabolic pathways: glucose oxidation, glycolysis, and fatty acid oxidation.

The particle, which has been called X(2900), was detected by analyzing all the data LHCb has recorded so far from collisions at CERNs Large Hadron Collider.

The LHCb experiment at CERN has developed a penchant for finding exotic combinations of quarks, the elementary particles that come together to give us composite particles such as the more familiar proton and neutron. In particular, LHCb has observed several tetraquarks, which, as the name suggests, are made of four quarks (or rather two quarks and two antiquarks). Observing these unusual particles helps scientists advance our knowledge of the strong force, one of the four known fundamental forces in the universe. At a CERN seminar held virtually on August 12, LHCb announced the first signs of an entirely new kind of tetraquark with a mass of 2.9 GeV/c²: the first such particle with only one charm quark.

First predicted to exist in 1964, scientists have observed six kinds of quarks (and their antiquark counterparts) in the laboratory: up, down, charm, strange, top and bottom. Since quarks cannot exist freely, they group to form composite particles: three quarks or three antiquarks form “baryons” like the proton, while a quark and an antiquark form “mesons.”