COVID-19 Research: Chinese researchers from the Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)-China led by Professor Dr Wei Congwen, have found the role of an HDL (high-density lipoprotein) receptor in the facilitation of entry of the SARS CoV-2 into human host cells.
The SARS-CoV-2 infects host cells through binding of the viral spike protein (SARS-2-S) to the cell-surface receptor angiotensin-converting enzyme 2 (ACE2).
Simulations that model molecular interactions have identified an enzyme that could be targeted to reverse a natural aging process called cellular senescence. The findings were validated with laboratory experiments on skin cells and skin equivalent tissues, and published in the Proceedings of the National Academy of Sciences (PNAS).
“Our research opens the door for a new generation that perceives aging as a reversible biological phenomenon,” says Professor Kwang-Hyun Cho of the Department of Bio and Brain engineering at the Korea Advanced Institute of Science and Technology (KAIST), who led the research with colleagues from KAIST and Amorepacific Corporation in Korea.
Cells respond to a variety of factors, such as oxidative stress, DNA damage, and shortening of the telomeres capping the ends of chromosomes, by entering a stable and persistent exit from the cell cycle. This process, called cellular senescence, is important, as it prevents damaged cells from proliferating and turning into cancer cells. But it is also a natural process that contributes to aging and age-related diseases. Recent research has shown that cellular senescence can be reversed. But the laboratory approaches used thus far also impair tissue regeneration or have the potential to trigger malignant transformations.
https://www.BetaGlucanShop.com — Natural killer cells (NK cells) are the most aggressive cells of your immune system and kills through apoptosis, also known as programmed cell death. These innate immune cells are key players against viral infections and cancer growth.
Natural killer cells help prevent metastasis by killing abnormal cells and tumour cells. Metastasis is the spread of cancer from one part of the body to another. Beta glucans are used in immunotherapy as they may help (depending on type) the immune system distinguish between healthy and abnormal cells like cancer cells, and thus direct the immune cells to engage cancer cells.
Research shows us that beta 1,3/1,6 glucans can trigger groups of immune cells including macrophages, neutrophils, monocytes, natural killer cells and dendritic cells for activity. Clinical human studies demonstrate that Wellmune Beta Glucan significantly increases the percent of active immune cells available to defend your body. Wellmune increases mobilization of innate immune cells to the site of a challenge, enabling faster recognition and neutralization of foreign intruders and killing (phagocytosis) of foreign challenges, resulting in a more complete immune response.
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The annual meeting of the Radiological Society of North America highlighted how artificial intelligence is being used to augment medical imaging.
RSNA 2020, the annual meeting of the Radiological Society of North America, showcases the latest research advances and product developments in all areas of radiology. Here’s a selection of studies presented at this year’s all-virtual event, all of which demonstrate the increasingly prevalent role played by artificial intelligence (AI) techniques in diagnostic imaging applications.
Deep-learning model helps detect TB
Early diagnosis of tuberculosis (TB) is crucial to enable effective treatments, but this can prove challenging for resource-poor countries with a shortage of radiologists. To address this obstacle, Po-Chih Kuo, from Massachusetts Institute of Technology, and colleagues have developed a deep-learning-based TB detection model. The model, called TBShoNet, analyses photographs of chest X-rays taken by a phone camera.
Using the polarization data from ESA’s Planck satellite, a mission that have studied the Cosmic Microwave Background (CMB), the oldest light in the Universe, a duo of astrophysicists has uncovered intriguing signs of new physics beyond the Standard Model of elementary particles and fields.