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Global brain activity seen on fMRI, and its connection with cerebrospinal fluid flow weaker in brains of individuals with Alzheimer’s disease risk or related toxin buildup.

Evidence of sleep-dependent low-frequency (0.1 Hz) global brain activity in the clearance of Alzheimer’s disease-related toxin buildup is presented in research published today (June 1, 2021) in the open access journal PLOS Biology by Xiao Liu and colleagues at The Pennsylvania State University. This neuronal activity was more strongly linked with cerebrospinal fluid flow in healthy controls than higher risk groups and patients, and the findings could serve as a potential imaging marker for clinicians in evaluating patients.

The development of Alzheimer’s disease is believed to be driven by the buildup of the toxic proteins amyloid-β and tau in the brain. The brain’s glymphatic system plays a crucial role in clearing these toxins and previous work has shown a possible relationship between sleep-dependent global brain activity and the glymphatic system by showing this activity is coupled by cerebrospinal fluid flow essential for the glymphatic system.

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I believe I posted about Nitric Oxide as treatment for covid19 ages ago. Apparently I was right. It also works under the UK variant, thus showing it can work under others as well.

Results of clinical trials conducted in the United Kingdom have shown that a nitric oxide nasal spray (NONS, SaNOtize) is both a safe and effective antiviral treatment to prevent COVID-19 transmission and symptom duration, as well as reduce symptom severity and damage in those already infected, according to the study authors.

“NONS destroys the virus, blocks entry into and halts viral replication within the nasal cavity, which rapidly reduces viral load. This is significant because viral load has been linked to infectivity and poor outcomes,” said Chris Miller, PhD, RT, chief science officer and co-founder of SaNOtize, in a press release. “There is currently a lack of an antiviral therapy that is effective against COVID-19 and its variants, can prevent or shorten the course of the disease, reduce damage, lower the severity of COVID-19, and can be made widely and readily available to the public.”

Results of clinical trials have shown that a nitric oxide nasal spray is both a safe and effective antiviral treatment to prevent COVID-19 transmission and symptom duration, as well as reduce symptom severity and damage in those already infected.

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Enlight uses light polarization to maximize resolution and to find critical defects in half the time of the typical optical scanner. The scanner for the first time will capture both direct light bouncing off the wafer surface, and scattered light, known as “brightfield” and “greyfield,” respectively. That’s like scanning two things in one pass, cutting in half the time required.

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Natural Language Processing (NLP) has seen rapid progress in recent years as computation at scale has become more available and datasets have become larger. At the same time, recent work has shown large language models to be effective few-shot learners, with high accuracy on many NLP datasets without additional finetuning. As a result, state-of-the-art NLP models have grown at an exponential rate (Figure 1). Training such models, however, is challenging for two reasons:

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Unlike in other years, this year’s Microsoft Build developer conference is not packed with huge surprises — but there’s one announcement that will surely make developers’ ears perk up: The company is now using OpenAI’s massive GPT-3 natural language model in its no-code/low-code Power Apps service to translate spoken text into code in its recently announced Power Fx language.

Now don’t get carried away. You’re not going to develop the next TikTok while only using natural language. Instead, what Microsoft is doing here is taking some of the low-code aspects of a tool like Power Apps and using AI to essentially turn those into no-code experiences, too. For now, the focus here is on Power Apps formulas, which despite the low-code nature of the service, is something you’ll have to write sooner or later if you want to build an app of any sophistication.

“Using an advanced AI model like this can help our low-code tools become even more widely available to an even bigger audience by truly becoming what we call no code,” said Charles Lamanna, corporate vice president for Microsoft’s low-code application platform.

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Most computer systems are designed to store and manipulate information, such as documents, images, audio files and other data. While conventional computers are programmed to perform specific operations on structured data, emerging neuro-inspired systems can learn to solve tasks more adaptively, without having to be engineered to carry out a set type of operations.

Researchers at University of Pennsylvania and University of California recently trained a (RNN) to adapt its representation of complex information based only on local data examples. In a paper published in Nature Machine Intelligence, they introduced this RNN and outlined the key learning mechanism underpinning its functioning.

“Every day, we manipulate information about the world to make predictions,” Jason Kim, one of the researchers who carried out the study, told TechXplore. “How much longer can I cook this pasta before it becomes soggy? How much later can I leave for work before rush hour? Such information representation and computation broadly fall into the category of working . While we can program a computer to build models of pasta texture or commute times, our primary objective was to understand how a neural learns to build models and make predictions only by observing examples.”

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Physicists at the University of Bath in the UK, in collaboration with researchers from the USA, have uncovered a new mechanism for enabling magnetism and superconductivity to co-exist in the same material. Until now, scientists could only guess how this unusual coexistence might be possible. The discovery could lead to applications in green energy technologies and in the development of superconducting devices, such as next-generation computer hardware.

As a rule, superconductivity (the ability of a material to pass an with perfect efficiency) and magnetism (seen at work in fridge magnets) make poor bedfellows because the alignment of the tiny electronic magnetic particles in ferromagnets generally leads to the destruction of the electron pairs responsible for superconductivity. Despite this, the Bath researchers have found that the iron-based superconductor RbEuFe4As4, which is superconducting below-236°C, exhibits both superconductivity and magnetism below-258°C.

Physics postgraduate research student David Collomb, who led the research, explained: There’s a state in some materials where, if you get them really cold—significantly colder than the Antarctic—they become superconducting. But for this superconductivity to be taken to next-level applications, the material needs to show co-existence with . This would allow us to develop devices operating on a magnetic principle, such as magnetic memory and computation using , to also enjoy the benefits of superconductivity.

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