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Optical tweezer sectioning microscopy enables 3D imaging of floating live cells

Three-dimensional (3D) imaging is essential for investigating cellular structure and dynamics. Traditional optical methods rely on adhesive or mechanical forces to hold and scan cells, which limit their applicability to suspended cells and may induce stress responses. Developing a non-contact, all-optical 3D imaging technique for live suspended cells remains a major challenge in advancing in situ biological research.

In a study published in Science Advances, Prof. Yao Baoli from the Xi’an Institute of Optics and Precision Mechanics (XIOPM) of the Chinese Academy of Sciences and Prof. Olivier J. F. Martin, from the Swiss Federal Institute of Technology, Lausanne, developed the optical tweezer sectioning (OTSM), enabling all-optical 3D imaging of suspended , which offers a powerful new tool for live-cell imaging, dynamic biological studies and multicellular assembly.

Researchers developed OTSM by integrating holographic optical tweezers (HOTs) with structured illumination microscopy (SIM).

Elusive romance of top-quark pairs observed at Large Hadron Collider

An unforeseen feature in proton-proton collisions previously observed by the CMS experiment at CERN’s Large Hadron Collider (LHC) has now been confirmed by its sister experiment ATLAS.

The result, reported yesterday at the European Physical Society’s High-Energy Physics conference in Marseille, suggests that —the heaviest and shortest-lived of all the elementary particles—can momentarily pair up with their antimatter counterparts to produce a “quasi-bound-state” called toponium. Further input based on complex theoretical calculations of the strong nuclear force—called (QCD)—will enable physicists to understand the true nature of this elusive dance.

High-energy collisions between protons at the LHC routinely produce top quark–antiquark pairs. Measuring the probability, or cross section, of this process is both an important test of the Standard Model of particle physics and a powerful way to search for the existence of new particles that are not described by the theory.

New quantum record: Transmon qubit coherence reaches millisecond threshold

On July 8, 2025, physicists from Aalto University in Finland published a transmon qubit coherence measurement in Nature Communications that dramatically surpasses previous scientifically published records. The millisecond coherence measurement marks a quantum leap in computational technology, with the previous maximum echo coherence measurements approaching 0.6 milliseconds.

Longer coherence allows for an extended window of time in which quantum computers can execute error-free operations, enabling more complex quantum computations and more quantum logic operations before errors occur. Not only does this allow for more calculations with noisy quantum computers, but it also decreases the resources needed for , which is a path to noiseless quantum computing.

“We have just measured an echo time for a transmon qubit that landed at a millisecond at maximum with a median of half a millisecond,” says Mikko Tuokkola, the Ph.D. student who conducted and analyzed the measurements. The median reading is particularly significant, as it also surpasses current recorded readings.

Pretrained jet foundation model successfully utilized for tau reconstruction

Simulating data in particle physics is expensive and not perfectly accurate. To get around this, researchers are now exploring the use of foundation models—large AI models trained in a general, task-agnostic way on large amounts of data.

Just like how language models can be pretrained on the full dataset of internet text before being fine-tuned for specific tasks, these models can learn from large datasets of particle jets, even without labels.

After the pretraining, they can be fine-tuned to solve specific problems using much less data than traditional approaches.

Black-hole solutions in quantum gravity with Vilkovisky-DeWitt effective action

Physicists propose that calculations of certain aspects of quantum gravity can currently be done even without a full theory of quantum gravity itself. Basically, they work backwards from the fact that quantum gravity on the macro scale must conform to Einstein’s relativity theories. This approach is effective until the small scale of a black hole singularity is close.

(See my Comment below for an article link to POPULAR MECHANICS that discussed the scientific article in an accessible manner.

We study new black-hole solutions in quantum gravity. We use the Vilkovisky-DeWitt unique effective action to obtain quantum gravitational corrections to Einstein’s equations. In full analogy to previous work done for quadratic gravity, we find new black-hole–like solutions. We show that these new solutions exist close to the horizon and in the far-field limit.

When stem cells feel the squeeze, they start building bone

In a discovery that could reshape approaches to regenerative medicine and bone repair, researchers have found that human stem cells can be prompted to begin turning into bone cells simply by squeezing through narrow spaces.

The study suggests that the physical act of moving through tight, confining spaces, like those between tissues, can influence how stem cells develop. This could open new possibilities for engineering materials and therapies by guiding using physical, rather than chemical, signals.

The research was led by Assistant Professor Andrew Holle from the Department of Biomedical Engineering in the College of Design and Engineering at the National University of Singapore (NUS), and the Mechanobiology Institute (MBI) at NUS, and was published on 8 May 2025 in the journal Advanced Science.

Jack Dorsey launches a WhatsApp messaging rival built on Bluetooth

CEO Jack Dorsey spent the weekend building Bitchat, a new decentralized, peer-to-peer messaging app that works entirely over Bluetooth mesh networks, with no internet, central servers, phone numbers or emails required.

The Twitter co-founder announced Sunday that the beta version is live on TestFlight, with a full white paper available on GitHub.

Block CEO Jack Dorsey has launched Bitchat, a new peer-to-peer messaging app that works entirely over Bluetooth mesh networks.

Elusive romance of top-quark pairs observed at the LHC

An unforeseen feature in proton-proton collisions previously observed by the CMS experiment at CERN’s Large Hadron Collider (LHC) has now been confirmed by its sister experiment ATLAS. The result, reported yesterday at the European Physical Society’s High-Energy Physics conference in Marseille, suggests that top quarks – the heaviest and shortest-lived of all the elementary particles – can momentarily pair up with their antimatter counterparts to produce a “quasi-bound-state” called toponium. Further input based on complex theoretical calculations of the strong nuclear force — called quantum chromodynamics (QCD) — will enable physicists to understand the true nature of this elusive dance.

High-energy collisions between protons at the LHC routinely produce top quark–antiquark pairs. Measuring the probability, or cross section, of this process is both an important test of the Standard Model of particle physics and a powerful way to search for the existence of new particles that are not described by the theory.

Last year, CMS researchers were analysing a large sample of top quark–antiquark production data collected from 2016 to 2018 to search for new types of Higgs bosons when they observed something unusual. The team saw a surplus of top quark–antiquark pairs, which is often considered as a smoking gun for the presence of new particles. Intriguingly, the excess appeared at the very minimum energy required to produce such a pair of top quarks. This led the team to consider an alternative hypothesis of something that had long been considered too difficult to detect at the LHC: a short-lived union of a top quark and a top antiquark.

Can psychedelic mushrooms turn back the clock? Study suggests psilocybin preserves telomere length

A compound found in psychedelic mushrooms may have antiaging properties. Researchers at Baylor College of Medicine have found that psilocybin, the active compound in psychedelic mushrooms, may extend both cellular and organismal lifespans.

The findings, published in the journal npj Aging, show that psilocybin reduced multiple hallmarks of aging in cells while also improving survival in aged mice.

“There have been a number of clinical studies that have explored the therapeutic potential of psilocybin in psychiatric conditions such as depression and anxiety; however, few studies have evaluated its impacts outside the brain,” said Dr. Louise Hecker, associate professor of medicine— at Baylor and senior author of the study.