Researchers discovered that the common amino acid arginine can block harmful Aβ aggregation and reduce its toxic effects in Alzheimer’s disease models. In flies and mice, oral arginine lowered plaque levels, reduced inflammation, and improved behavior. Its strong safety record and low cost make it a promising repurposing candidate. The findings hint at a surprisingly simple path toward more accessible AD therapies.
Researchers at Baylor College of Medicine have discovered a natural mechanism that clears existing amyloid plaques in the brains of mouse models of Alzheimer’s disease and preserves cognitive function. The mechanism involves recruiting brain cells known as astrocytes, star-shaped cells in the brain, to remove the toxic amyloid plaques that build up in many Alzheimer’s disease brains.
Increasing the production of Sox9, a key protein that regulates astrocyte functions during aging, triggered the astrocytes’ ability to remove amyloid plaques. The study, published in Nature Neuroscience, suggests a potential astrocyte-based therapeutic approach to ameliorate cognitive decline in neurodegenerative disease.
“Astrocytes perform diverse tasks that are essential for normal brain function, including facilitating brain communications and memory storage. As the brain ages, astrocytes show profound functional alterations; however, the role these alterations play in aging and neurodegeneration is not yet understood,” said first author Dr. Dong-Joo Choi, who was at the Center for Cell and Gene Therapy and the Department of Neurosurgery at Baylor while he was working on this project. Choi currently is an assistant professor at the Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine at the University of Texas Health Science Center at Houston.
This is a ~1 hour 12 minute talk titled “Computational Symbiogenesis” by Blaise Agüera y Arcas (https://research.google/people/106776/?&type=google), given for our symposium on the Platonic Space (https://thoughtforms.life/symposium-on-the-platonic-space/).
Biologist Michael Levin—creator of the world’s first living robots—reveals a radical, evidence-based view of evolution driven by a fundamental mind, where agency emerges in unexpected places and what this means for humanity’s co-evolution with AI and AGI.
▶️ Read the article on Forbes.com \.
In January, a team led by Jim Schuck, professor of mechanical engineering at Columbia Engineering, developed a method for creating entangled photon pairs, a critical component of emerging quantum technologies, using a crystalline device just 3.4 micrometers thick.
Now, in a paper published in Nature Photonics in October, Columbia Engineers have shrunk nonlinear platforms with high efficiency down to just 160 nanometers by introducing metasurfaces: artificial geometries etched into ultrathin crystals that imbue them with new optical properties.
“We’ve established a successful recipe to pattern ultrathin crystals at the nanoscale to enhance nonlinearity while maintaining their sub-wavelength-thickness,” said corresponding author Chiara Trovatello is currently an assistant professor at Politecnico di Milano and was a Marie Skłodowska-Curie Global Fellow at Columbia working with Schuck.
An environmental chemistry laboratory at Duke University has solved a longstanding mystery of the origin of high levels of PFAS—so-called “forever chemicals”—contaminating water sources in the Piedmont region of North Carolina.
By sampling and analyzing sewage in and around Burlington, NC, the researchers traced the chemicals to a local textile manufacturing plant. The source remained hidden for years because the facility was not releasing chemical forms of PFAS that are regulated and monitored. The culprit was instead solid nanoparticle PFAS “precursors” that degrade into the chemicals that current tests are designed to detect.
Incredibly, these precursors were being released into the sewer system at concentrations up to 12 million parts-per-trillion—approximately 3 million times greater than the Environmental Protection Agency’s recently-enacted drinking water regulatory limit for certain types of PFAS.