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Beyond the brain: Organs help shape the nervous systems that control them

A new Yale study reveals that major organ systems in the body aren’t just passive structures operating on directions from command central—the brain—but instead are active participants in controlling their own functions.

Writing in the journal Nature, a team of researchers led by Yale’s Rui Chang demonstrates how organs develop and maintain their own neural circuitry, which in turn communicates with the brain in a sort of two-way conversation.

The findings provide a new understanding of how the body and brain communicate via networks of neurons embedded inside organs that constitute a mini-nervous system, called “organ intrinsic nervous systems,” which help control critical functions such as digestion, heart rhythm, breathing, insulin secretion, and immune responses, the researchers say.

AI misses cancer drug target, revealing why lab validation still matters

Researchers at the Icahn School of Medicine at Mount Sinai have identified a previously hidden druggable site in a cancer-related protein that could open the door toward the development of a new generation of more precise cancer drugs. The finding also reveals important limitations in today’s artificial intelligence tools for drug discovery.

The study, published in the June 2 online issue of the Journal of the American Chemical Society, focused on PKMYT1, a type of protein known as a kinase that helps control how cells grow and divide. Because this process can go wrong in cancer, PKMYT1 has emerged as a promising target for new cancer drugs.

Most experimental drugs designed to block kinases work by targeting a region called the ATP-binding site—the part of the protein that uses the cell’s energy supply to function. But many kinases share nearly identical ATP-binding sites, making it difficult for drugs to distinguish between the desired target and other kinases, which can lead to unwanted side effects.

Novel prostate cancer treatment can reduce risk of disease progression by half, clinical trial shows

A Phase III clinical trial led by Neeraj Agarwal, MD, FASCO, senior director of clinical research at Huntsman Cancer Institute and professor of internal medicine at the University of Utah (the U), has found that a combination prostate cancer treatment could prevent the disease from progressing into a harder-to-treat form of cancer in select patients.

The study, TALAPRO-3 (NCT04821622), evaluated a combination of two drugs—talazoparib and enzalutamide—in patients with metastatic castration-sensitive prostate cancer. This is a form of the disease that has spread beyond the prostate but remains susceptible to standard hormone therapy treatment.

The patients involved also had prostate cancer affected by certain gene mutations, including but not limited to BRCA1 and BRCA2 mutations, that often signal more aggressive disease.

Life-changing benefits of hydroxyurea for sickle cell anemia affirmed by 10-year study

Fewer serious complications. Fewer hospitalizations and blood transfusions. Better growth and development. And a markedly lower risk of death from the complications of sickle cell anemia.

These are the benefits documented from 10 years of continuous hydroxyurea treatment provided in the NOHARM trial to a group of young children in Uganda, which has one of the world’s largest number of people living with the painful disorder known for causing sickle-shaped red blood cells. These improved outcomes were highlighted May 27, 2026, in a report published by the New England Journal of Medicine.

Russell Ware, MD, Ph.D., director of the Division of Hematology and the Global Health Center at Cincinnati Children’s, was the lead author of the report. He has been working for years with researchers and clinicians across sub-Saharan Africa to demonstrate the safety and effectiveness of low-cost hydroxyurea treatments.

Study Suggests Spacetime Can Crystallize Possibly Solving Several Mysteries

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Hello and welcome! My name is Anton and in this video, we will talk about crystallization of spacetime.
Links:
https://journals.aps.org/prl/pdf/10.1
#science #physics #spacetime.

0:00 Can spacetime crystallize?
0:35 So what is this then?
1:55 Let’s define the main terms and phenomena: spacetime.
2:30 Crystals.
2:55 Spacetime crystal.
3:50 Previous challenges and propositions.
5:10 Main achievement in the study.
6:10 What does any of this mean for us?
7:10 Solving singularity and quantum gravity?
8:05 Explaining dark matter?
8:45 JWST observations.
9:28 Any proof? Gravitational waves!
11:55 Conclusions.

Enjoy and please subscribe.

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AI-Discovered Cognitive Models Reveal Novel Insights into Human and Animal Learning

The problem? Human brains (and animal brains, too) are incredibly complex. While these handcrafted models are great starting points, they often oversimplify things and miss the messy, rich reality of actual behavior. On the flip side, using powerful, flexible AI to analyze data can capture that richness, but AI usually gives us a “black box”—it finds patterns but can’t explain *why* or *how* it found them, leaving scientists to do the heavy lifting of figuring out the rules.


Scientific models are widely used across the natural sciences as an interface between scientific theories and empirical data [1]. Such models play a key role, for example, in the study of human and animal learning, where they express algorithmic hypotheses and relate them to psychology and neuroscience data [2, 3]. These models are traditionally handcrafted by expert researchers based on existing theory or new insights. Such handcrafted models, however, are now known to fall short of capturing the full richness of behavior, even in their narrow domains [47]. An alternative data-driven approach has emerged, seeking to discover new insights by fitting and interpreting flexible models [811]. However, these tools require substantial human effort to derive insight from data, and it has been unclear how to discover new ideas from data efficiently. Here, we present DataDIVER, a general approach for automatically discovering computational models from data, and demonstrate that these models surface novel mechanistic insights into human and animal learning. Our approach delivers models that take the form of short computer programs, which are optimized both to fit data well and to be simple. These programs explicitly connect with existing theoretical frameworks and are readily understandable by human scientists. They can also be used to make novel predictions, some of which we show are borne out in re-analysis of existing data. General-purpose tools for surfacing new ideas from data, especially in combination with the large datasets that are increasingly available in many fields, stand to dramatically accelerate scientific discovery.

The authors have declared no competing interest.

Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids

Zhang et al. found that two waves of apoptosis occur in developing human retinas and retinal organoids, affecting RPCs and RGCs, respectively. Retinal organoids undergo an additional wave of necrosis in the core, further eliminating RGCs. Blocking apoptosis in organoids promotes RGC long-term survival and delays their neurogenesis and maturation.

Senescent cells dodge cell death by rewiring fat metabolism, study shows

In response to stress or damage, cells undergo senescence and stop dividing. However, if senescent cells accumulate in tissues over the long term, chronic inflammation occurs and the risk of cancer increases. Researchers at the German Cancer Research Center (DKFZ) have now discovered a previously unknown mechanism by which senescent cells protect themselves from oxidative stress and a specific form of cell death known as ferroptosis.

In the long term, these findings could provide new avenues for cancer therapies and the treatment of age-related diseases. The research is published in the journal Cell Death & Differentiation.

Senescence occurs when cells respond to stress or harmful changes and permanently cease their growth. This process is considered a protective mechanism against cancer. For example, cells that carry an oncogene permanently activated by mutations are effectively “frozen” before they can proliferate uncontrollably—a biological emergency program. However, problems arise when senescent cells accumulate in tissue, where they promote chronic inflammation and thus facilitate tumor development. Scientists are therefore searching for ways to eliminate senescent cells before they can cause harm.

50 Best Cybersecurity Keynote Speakers in the USA

IntroductionIf you are searching for the best cybersecurity keynote speakers in the USA, you already know the challenge. Most lists recycle the same handful of well-known names, without telling you which speaker actually fits your audience, your industry, or your budget. This directory changes that. Every person included has been selected based on substantive cybersecurity credentials, demonstrated speaking impact, and active contribution to the field in 2025 and 2026.The stakes have never been

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