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Welcome back to The TechCrunch Exchange, a weekly startups-and-markets newsletter. It’s broadly based on the daily column that appears on Extra Crunch, but free, and made for your weekend reading. Want it in your inbox every Saturday morning? Sign up here.

Earnings season is coming to a close, with public tech companies wrapping up their Q4 and 2020 disclosures. We don’t care too much about the bigger players’ results here at TechCrunch, but smaller tech companies we knew when they were wee startups can provide startup-related data points worth digesting. So, each quarter The Exchange spends time chatting with a host of CEOs and CFOs, trying to figure what’s going on so that we can relay the information to private companies.

Sometimes it’s useful, as our chat with recent fintech IPO Upstart proved after we got to noodle with the company about rising acceptance of AI in the conservative banking industry.

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The 21-digit solution to the decades-old problem suggests many more solutions exist.

What do you do after solving the answer to life, the universe, and everything? If you’re mathematicians Drew Sutherland and Andy Booker, you go for the harder problem.

In 2019, Booker, at the University of Bristol, and Sutherland, principal research scientist at MIT, were the first to find the answer to 42. The number has pop culture significance as the fictional answer to “the ultimate question of life, the universe, and everything,” as Douglas Adams famously penned in his novel “The Hitchhiker’s Guide to the Galaxy.” The question that begets 42, at least in the novel, is frustratingly, hilariously unknown.

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Summary: Using a range of tools from machine learning to graphical models, researchers have discovered a new way to identify cells and explore the mechanisms behind neurodegenerative diseases.

Source: Georgia Institute of Technology

In researching the causes and potential treatments for degenerative conditions such as Alzheimer’s or Parkinson’s disease, neuroscientists frequently struggle to accurately identify cells needed to understand brain activity that gives rise to behavior changes such as declining memory or impaired balance and tremors.

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The remains reveal that Waal was between 35 and 50 years old when he died. Researchers used techniques including radiocarbon dating, stratigraphy and ceramic typology to determine that people buried him in around 726 A.D., the same year workers built the hieroglyphic staircase, notes Notimerica.

Prior to his death, Waal suffered from a variety of medical ailments. His skull was mildly flattened, and he was malnourished as a child, as evidenced by the “slightly porous, spongy areas known as porotic hyperostosis, caused by childhood nutritional deficiencies or illnesses” on the sides of his head, per the statement.

Scientists also found that infections, trauma, scurvy or rickets had triggered periostitis —chronic swelling and pain—to form in Waal’s arm bones.

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Long but annotated! Most important here is human data for specific treatments due out starting in May or June. And apparently they had a mouse study where they expected a paper due out already but other groups chimed in to help with more testing so there is a delay.

Liz Parrish, CEO of BioViva Science and patient zero of biological rejuvenation with gene therapies, is interviewed by Zora Benhamou on her fresh podcast “HackMyAge”.

During the conversation, Liz enters deep into the world of gene therapies, either to cure monogenic diseases, multifactorial genetic diseases, or the mother of all diseases: aging itself.

Continue reading “Liz Parrish goes deep into gene therapies at the HackMyAge Podcast by Zora (March 2021)” | >

By Chuck Brooks

The world of computing has witnessed seismic advancements since the invention of the electronic calculator in the 1960s. The past few years in information processing have been especially transformational. What were once thought of as science fiction fantasies are now technological realties. Classical computing has become more exponentially faster and more capable and our enabling devices smaller and more adaptable.

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