Lifeboat Foundation

NRF2 is just one of thousands of critical proteins in the cell, but it is one that we now know a lot about. Once any molecule achieves a certain level of celebrity status, it tends to acquire a groupie following in the supplement market. Today, we have all manner of NRF enhancers, releasers, activators and synergizers ready to arrive on your doorstep at the click of a button. But what could any of these things possibly do for us, and how much is too much of a good thing?

At the risk of overstating the obvious, if a little extra NRF2 is good for every cell in your body, and every cell in your body is good, then NRF2 must be good for your body. The weak link in that argument, however, is that all cells are not good. Nobody wants harmful bacterial cells to flourish, and nobody wants cancer cells to flourish. A paper recently published in Nature now suggests that inhibiting NRF2 can block the migration and invasion of non-small-cell lung cancer cells through the body. If anyone is going to derive benefit from NRF2, they may need to be smart about it.

The main reason NRF2, or Nuclear factor-erythroid 2-related factor 2, is so highly sought, is because it is a key transcriptional regulator of several antioxidant and anti-inflammatory enzymes. Unfortunately, as the authors above have revealed, it also moonlights as an activator of the Rho-ROCK pathway, which promotes actin filamentation and movement of cells. The researchers were able to block this activity of NRF2 by giving an inhibitor known as brusatol.

A friend recently asked me “what do we mean by civilian space development”.Such a question made me understand that, maybe, we were not clear enough about the title of our congress, the Civilian Space Development. Following such understanding, I tried to draw a better rationale, aware that what we wrote was not that self-explanatory as we thought.

It was observed that NASA is a civilian agency, not a military one. And that the commercial space effort is civilian process, not a military one.

The Man Said That His Country Has Been In Existence For 1000 Years And Was A Little Puzzled Why His Country Was Called Andorra On The Map.

It was July 1954 when a smartly dressed man arrives at Haneda Airport in Tokyo, Japan. Much like other passengers, he makes his way to customs. But whatever happened from this point onwards have left all puzzled and concerned. When questioned by the customs officers, the mysterious passenger said he was from Taured, also referred to as Taured Mystery. The mystery man claimed that it was the third time he was visiting Japan from his country. But, to the surprise of officers, they couldn’t find any country named Taured. The primary language of the man, described as Caucasian looking with a beard, was French. However, she was purportedly speaking Japanese and many other languages as well.

Officers were perplexed because they had never heard about any such country. The passport of the man was issued by of course the Taured. The passport looked authentic but the place was not recognized.

Continue reading “Taured Mystery: The Man Who Vanished As Mysteriously As He Came” »

Summary: Better glucose uptake compensates for age-related motor deterioration and extends lifespan in fruitflies.

Source: Tokyo Metropolitan University.

Researchers from Tokyo Metropolitan University have discovered that fruit flies with genetic modifications to enhance glucose uptake have significantly longer lifespans.

A legally blind 78-year old man has regained his sight after being the inaugural patient to receive a promising new type of corneal implant, Israel Hayom has reported. Developed by a company called CorNeat, the KPro is the first implant that can be integrated directly into the eye wall to replace scarred or deformed corneas with no donor tissue. Immediately after the surgery, the patient was able to recognize family members and read numbers on an eye chart.

The corona is the clear layer that covers and protects the front portion of the eye. It can degenerate or scar for various reasons, including diseases like pseudophakic bullous keratopathy, kerotoconus and trauma.

These cute drones are partially made from the trashed leaves of harvested pineapples which make them lighter, faster and most importantly greener! 🍍.

Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement. This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own.

There are two major hurdles to overcome on the road to laboratory-grown organs and tissues. The first is to use a biologically compatible 3D scaffold in which cells can grow. The second is to decorate that scaffold with biochemical messages in the correct configuration to trigger the formation of the desired organ or tissue.

In a major step toward transforming this hope into reality, researchers at the University of Washington have developed a technique to modify naturally occurring biological polymers with protein-based biochemical messages that affect cell behavior. Their approach, published the week of Jan. 18 in the Proceedings of the National Academy of Sciences, uses a near-infrared laser to trigger chemical adhesion of protein messages to a scaffold made from biological polymers such as collagen, a connective tissue found throughout our bodies.

Biologists balk at any talk of ‘goals’ or ‘intentions’ — but a bold new research agenda has put agency back on the table.

Animal immune systems depend on white blood cells called macrophages that devour and engulf invaders. The cells pursue with determination and gusto: under a microscope you can watch a blob-like macrophage chase a bacterium across the slide, switching course this way and that as its prey tries to escape through an obstacle course of red blood cells, before it finally catches the rogue microbe and gobbles it up.

But hang on: isn’t this an absurdly anthropomorphic way of describing a biological process? Single cells don’t have minds of their own – so surely they don’t have goals, determination, gusto? When we attribute aims and purposes to these primitive organisms, aren’t we just succumbing to an illusion?

Continue reading “The biological research putting purpose back into life” »

We are creating compelling homegrown solutions in education, health care, agriculture, infrastructure, financial services and new commerce,” Ambani said in his speech. “Each of these solutions, once proven in India, will be offered to the rest of the world to address global challenges.

Mukesh Ambani has spent years trying to turn his inherited oil business into a tech empire. In 2020, that pivot really kicked into overdrive.