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Blog – Page 6725

I could probably be described as a SpaceX enthusiast. I catch their launches when I can, and I’ve watched the development of Starship with great interest. But the side-effect of SpaceX’s reusable launch system is that getting to space has become a lot cheaper. Having excess launch capacity means that space projects that were previously infeasible become suddenly at least plausible. One of those is Starlink.

Starlink is SpaceX’s satellite Internet service. Wireless and cellular internet have helped in some places, but if you really live out in the sticks, satellite internet is your only option. And while satellite Internet isn’t exactly new, Starlink is a bit different. Hughesnet, another provider, has a handful of satellites in geostationary orbit, which is about 22000 miles above the earth. To quote Grace Hopper, holding a nearly foot-long length of wire representing a nanosecond, “Between here and the satellite, there are a very large number nanoseconds.”

SpaceX opted to do something a bit different. In what seemed like an insane pipe dream at the time, they planned to launch a satellite constellation of 12000 birds, some of them flying as low as 214 mile altitude. The downside of flying so low is that they won’t stay in orbit as long, but SpaceX is launching them significantly faster than they’re coming down. So far, nearly 1600 Starlink satellites are in orbit, in a criss-crossing pattern at 342 miles (550 km) up.

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How do simple creatures manage to move to a specific place? Artificial intelligence and a physical model from TU Wien can now explain this.

How is it possible to move in the desired direction without a brain or nervous system? Single-celled organisms apparently manage this feat without any problems: for example, they can swim towards food with the help of small flagellar tails.

How these extremely simply built creatures manage to do this was not entirely clear until now. However, a research team at TU Wien (Vienna) has now been able to simulate this process on the computer: They calculated the physical interaction between a very simple model organism and its environment. This environment is a liquid with a non-uniform chemical composition, it contains food sources that are unevenly distributed.

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A research team from TU Wien together with US research institutes came across a surprising form of ‘quantum criticality’; this could lead to a design concept for new materials.

In everyday life, phase transitions usually have to do with temperature changes — for example, when an ice cube gets warmer and melts. But there are also different kinds of phase transitions, depending on other parameters such as magnetic field. In order to understand the quantum properties of materials, phase transitions are particularly interesting when they occur directly at the absolute zero point of temperature. These transitions are called “quantum phase transitions” or a “quantum critical points.”

Such a quantum critical point has now been discovered by an Austrian-American research team in a novel material, and in an unusually pristine form. The properties of this material are now being further investigated. It is suspected that the material could be a so-called Weyl-Kondo semimetal, which is considered to have great potential for quantum technology due to special quantum states (so-called topological states). If this proves to be true, a key for the targeted development of topological quantum materials would have been found. The results were found in a cooperation between TU Wien, Johns Hopkins University, the National Institute of Standards and Technology (NIST) and Rice University and has now been published in the journal Science Advances.

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Drug Delivery.

Covid-19

Without these lipid shells, there would be no mRNA vaccines for COVID-19.

Fragile mRNA molecules used in COVID-19 vaccines can’t get into cells on their own. They owe their success to lipid nanoparticles that took decades to refine by.

Ryan Cross

Continue reading “Without these lipid shells, there would be no mRNA vaccines for COVID-19” | >

It’s been nearly two decades since medical science has produced a new treatment for Alzheimer’s. Is that drought about to end?

June 7 will be a big day in the life of Jeff Borghoff — not to mention the more than 6 million other Americans living with Alzheimer’s disease.

On that date, the U.S. Food and Drug Administration is expected to announce whether it will give its blessing to the first new drug for the treatment of Alzheimer’s since 2003.

Borghoff fervently hopes the answer is yes. The 57-year-old resident of Forked River has been taking the drug for several years now, and he’s convinced it has helped significantly slow the progression of his dementia.

Continue reading “A breakthrough at last? Millions with Alzheimer’s anxiously await FDA decision on new drug” | >

I could find hardly any scientific studies that showed negative results from the Mediterranean Diet for longevity, which honestly makes me a little wary of scientific establishment groupthink.

That said, I think I am going to start taking shots of olive oil after all my research…

Is the Mediterranean Diet the key to longevity? Lots of research suggests olive oil and other Mediterranean foods can help you live longer.

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A team of researchers from Verve Therapeutics and the Perelman School of Medicine at the University of Pennsylvania has developed a CRISPR gene-editing technique that lowered the levels of cholesterol in the blood of test monkeys. In their paper published in the journal Nature, the researchers describe their technique.

Prior research has shown that in some people, the PCSK9 gene codes excess PCSK9 protein production (which occurs mostly in the liver)—leading to an increase in lipoprotein cholesterol levels in the bloodstream. This is because it interferes with blood cells with LDL receptors that “grab” LDL and remove it. For this reason, have developed therapies that reduce the production of PCSK9 protein. However, most do not work well enough, which is why there is still so much atherosclerotic cardiovascular disease. In this new effort, the researchers have tried another approach—altering the PCSK9 gene to make it stop coding for PCSK9 protein production.

The approach involved using a base editing technology made up of messenger RNA encoding for an along with guided RNA that was packaged in a lipid nanoparticle. Notably, the base editing technique was able to substitute a single nucleotide with another in the DNA without cutting the double helix. Prior research has shown the technique to be more precise, which means fewer errors than other CRISPR techniques. In their work, the researchers replaced an adenine with a guanine and a thymine with a cytosine, completely incapacitating the gene. Implementation of the therapy involved a one-time injection into the liver of cynomolgus monkeys.

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