Lifeboat Foundation

Cambridge/Jena (16.11.2020) Linkages between organic and inorganic materials are a common phenomenon in nature, e.g., in the construction of bones and skeletal structures. They often enable combinations of properties that could not be achieved with just one type of material. In technological material development, however, these so-called hybrid materials still represent a major challenge today.

A new class of hybrid glass materials

Researchers from the Universities of Jena (Germany) and Cambridge (GB) have now succeeded in creating a new class of hybrid glass materials that combine organic and inorganic components. To do this, the scientists use special material combinations in which chemical bonds between organometallic and inorganic glasses can be generated. They included materials composed of organometallic networks—so-called metal-organic frameworks (MOFs)—which have recently been experiencing rapidly increasing research interest. This is primarily because their framework structures can be created in a targeted manner, from the length scale of individual molecules up to a few nanometers. This achieves a control of porosity which can be adapted to a large number of applications, both in terms of the size of the pores and their permeability, and in terms of the chemical properties prevailing on the pore surfaces.

Interesting.

The building blocks of life can form even before there are stars or planets, a team of researchers have found in a study.

The new research looked at “dark chemistry”, or the ways that new kinds of materials can form without energetic radiation.

Continue reading “The building blocks of life can form even without stars or planets, scientists say” »

Maithra Raghu, a research scientist at Google Brain, is betting that neural networks can become a powerful tool in medicine.

NAD+ (nicotinamide adenine dinucleotide), a key metabolite central to an efficient and healthy metabolism, declines with age. This previously unexplained phenomena is associated with numerous age-related diseases and has spawned the development of many nutritional supplements aimed at restoring NAD+ to more youthful levels. Publishing in Nature Metabolism, researchers at the Buck Institute have identified chronic inflammation as a driver of NAD+ decline. They show that an increasing burden of senescent cells, which is also implicated in the aging process, causes the degradation of NAD via the activation of CD38 (cyclic ADP ribose hydrolase) a protein that is found on the cell membranes both inside and on the surface of many immune cells.

“We are very excited to link two phenomena which have been separately associated with aging and age-related disease,” said Eric Verdin, MD, Buck Institute President and CEO and senior author of the paper. “The fact that NAD+ decline and chronic inflammation are intertwined provides a more holistic, systemic approach to aging and the discovery of CD38 macrophages as the mediator of the link between the two gives us a new target for therapeutic interventions.”

AgelessRx claims that PEARL is the first nationwide telemedicine trial and one of the first large-scale intervention trials on Longevity. The human trial is a stepping stone to the way to bringing rapamycin to the Longevity market. PEARL (Participatory Evaluation of Aging with Rapamycin for Longevity) is a $600,000 trial with the University of California. They will evaluate the safety and effectiveness of rapamycin in 200 healthy adults for Longevity in double-blind, randomized, placebo-controlled trial.

Interested patients will be screened for eligibility using telemedicine. Eligible patients include those aged 50–85 of any sex, any ethnicity, in relatively good health, with only well-managed, clinically stable chronic diseases.

TAME is a separate $75 million trial to clinically evaluate Metformin drugs for Longevity properties. TAME has a composite primary endpoint – of stroke, heart failure, dementia, myocardial infarction, cancer and death. Rather than attempting to cure one endpoint, it will look to delay the onset of any endpoint, extending the years in which subjects remain in good health – their healthspan. A $40 million donation has been combined with a $35 million NIH grant to fund the TAME trial.

AMD announces its Instinct MI100 data center GPUs that boast record-breaking FP64 throughput.

In a study that gives new meaning to the term “rock bottom,” seismic researchers have discovered the underside of a rocky slab of Earth’s surface layer, or lithosphere, that has been pulled more than 400 miles beneath northeastern China by the process of tectonic subduction.

The study, published by a team of Chinese and U.S. researchers in Nature Geoscience, offers news evidence about what happens to water-rich oceanic tectonic plates as they are drawn through Earth’s mantle beneath continents.

Rice University seismologist Fenglin Niu, a co-corresponding author, said the study provides the first high-resolution seismic images of the top and bottom boundaries of a rocky, or lithospheric, tectonic plate within a key region known as the mantle transition zone, which starts about 254 miles (410 kilometers) below Earth’s surface and extends to about 410 miles (660 kilometers).

Where do you typically go to get the most up-to-date news on anti-aging research studies?

I’ve been digging around and found some longevity journals and other resources but curious to know what else is out there.

One of the most-frequent questions prominent longevity experts get asked is, “How can I contribute?”

Continue reading “14 Best Anti-Aging Research Journals for 2021” »

Machine-learning system GPT-3 has drawn plaudits from around the world for its remarkable ability to generate text with minimal human input. One scientist even believes it is showing signs of consciousness dailystar.