Lifeboat Foundation: Safeguarding Humanity
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Bill Gates made headlines for becoming the largest private farmland owner in the U.S. But he’s not the only one. Some of the wealthiest landowners including Jeff Bezos, John Malone and Thomas Peterffy are buying up forests, ranches and farmlands across the United States. Why? Watch the video to find out.

Investments in farmland are growing across the country as people, including the ultra-wealthy like Bill Gates, look for new ways to grow their money.

In 2,020 Gates made headlines for becoming the largest private farmland owner in the U.S. He had accumulated more than 269,000 acres of farmland across 18 states in less than a decade. His farmland grows onions, carrots and even the potatoes that are used to make McDonald’s French fries.

“It’s an asset with increasing value,” American Farmland Trust CEO John Piotti said. “It has great intrinsic value and beyond that, it is a limited resource.”

Continue reading “Why Bill Gates Is Buying Up U.S. Farmland” | >

In order to find a way to trick the body into making new B cells, the researchers probed one of the ways that the body naturally replenishes its supply. Patients undergoing treatment for multiple sclerosis had their MBC stock depleted, at which point their body rapidly started to produce new B cells.

The team identified the specific hormones that shut B cell production down again once stores were replenished, and realized that deactivating the hormone results in the body producing extra B cells left and right. And going forward, they hope to turn that hormonal trick into a new rejuvenating treatment for the elderly and immunocompromised.

“We found specific hormonal signals produced by the old B cells, the memory cells, that inhibit the bone marrow from producing new B cells,” Melamed told The Jerusalem Post. “This is a huge discovery. It is like finding a needle in a haystack.”

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A structural model of the SARS-CoV-2 spike protein as the virus fuses with host human cells reveals an opportunity to disrupt dynamics and halt transmission.

Scientists have simulated the transition of the SARS-CoV-2 spike protein structure from when it recognizes the host cell to when it gains entry, according to a study published on August 31 2021, in eLife.

The research shows that a structure enabled by sugar molecules on the spike protein could be essential for cell entry and that disrupting this structure could be a strategy to halt virus transmission.

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New material maintains borophene ’s electronic properties, offers new advantages.

For the first time, Northwestern University engineers have created a double layer of atomically flat borophene, a feat that defies the natural tendency of boron to form non-planar clusters beyond the single-atomic-layer limit.

Although known for its promising electronic properties, borophene — a single-atom.

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Baricitinib is an oral selective Janus kinase 1/2 inhibitor with known anti-inflammatory properties. This study evaluates the efficacy and safety of baricitinib in combination with standard of care for the treatment of hospitalised adults with COVID-19.

In this phase 3 double-blind, randomised, placebo-controlled trial, participants were enrolled from 101 centres across 12 countries in Asia, Europe, North America, and South America. Hospitalised adults with COVID-19 receiving standard of care were randomly assigned (1:1) to receive once-daily baricitinib (4 mg) or matched placebo for up to 14 days. Standard of care included systemic corticosteroids, such as dexamethasone, and antivirals, including remdesivir. The composite primary endpoint was the proportion who progressed to high-flow oxygen, non-invasive ventilation, invasive mechanical ventilation, or death by day 28 assessed in the intention-to-treat population. All-cause mortality by day 28 was a key secondary endpoint, and all-cause mortality by day 60 was an exploratory endpoint; both were assessed in the intention-to-treat population. Safety analyses were done in the safety population defined as all randomly allocated participants who received at least one dose of study drug and who were not lost to follow-up before the first post-baseline visit. This study is registered with ClinicalTrials-gov, NCT04421027.

Although there was no significant reduction in the frequency of disease progression overall, treatment with baricitinib in addition to standard of care (including dexamethasone) had a similar safety profile to that of standard of care alone, and was associated with reduced mortality in hospitalised adults with COVID-19.

Eli Lilly and Company.

Continue reading “Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial” | >

Over a year since the history-making operation, the recipient of the world’s first total penis and scrotum transplant – an injured veteran of the US Armed Forces – is “feeling whole” again and recovering well, doctors report in a case note on the pioneering procedure.

The man, who remains anonymous, was on patrol with his squad in Afghanistan when Taliban fighters ambushed them. As he went to give first aid to another soldier, he stepped on an improvised explosive device hidden on the road. In an instant, the blast took away much of the lower half of his body.

“I remember everything froze and I was upside down,” the man told MIT Technology Review. “I remember thinking a quick thought: ‘This isn’t good.’”

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Program aims to fortify supply chain by utilizing bioengineering approaches to facilitate REE separation and purification.

Rare Earth Elements (REEs) are a group of 17 similar metals that are critical material components of many DoD systems, including lasers, precision-guided weapons, magnets for motors, and other devices.1 Although the U.S. has adequate domestic REE resources, its supply chain is vulnerable due to dependence on foreign entities for separation and purification of these elements. “Biomining,” an approach that uses microbes to extract or separate target metals like gold or copper from a variety of sources is not yet useful for REEs because of poor specificity and selectivity of the microbes for REEs. The Environmental Microbes as a BioEngineering Resource (EMBER) program aims to leverage advances in microbial and biomolecular engineering to develop a scalable bio-based separation and purification strategy for REEs using under-developed domestic sources.

“The EMBER program will aim to fill a critical DoD supply chain gap” stated Dr. Linda Chrisey, EMBER program manager. “The program will target the development of bioengineered organisms/biomolecular approaches for REE purification, then translate these to practical biomining modules (e.g., biosorbent, biofiltration) that can be integrated with domestic REE sources.”

The four-year program will address two Technical Areas (TAs) and be divided into three phases. The goal of TA1, “Bioengineering for REE Utilization,” is to establish a platform for engineering organisms and/or biomolecules to enable the binding of REEs under harsh conditions. TA2, “REE Biomining” will focus on developing and testing a biomining workflow to purify individual REEs from actual source materials. Teams must propose to both TAs to develop comprehensive, enduring solutions.

Continue reading “Developing Cohesive, Domestic Rare Earth Element (REE) Technologies” | >