Lifeboat Foundation

They need to speed these processes along.

Many modern fitness trackers and smartwatches feature integrated LEDs. The green light emitted, whether continuous or pulsed, penetrates the skin and can be used to measure the wearer’s heart rate during physical activity or while at rest.

These watches have become extremely popular. A team of ETH researchers now wants to capitalize on that popularity by using the LEDs to control genes and change the behavior of cells through the skin. The team is led by Martin Fussenegger from the Department of Biosystems Science and Engineering in Basel. He explains the challenge to this undertaking: “No naturally occurring molecular system in human cells responds to green light, so we had to build something new.”

Continue reading “Activating Genes With a Smartwatch to Control Insulin Production” »

Hundreds of websites worldwide crashed this morning following a massive internet outage – with the UK government, Amazon and Spotify among those experiencing issues.

Millions of users across the globe reported problems trying to access web pages, with Netflix, Twitch and news websites including the BBC, Guardian, CNN and the New York Times hit by the problem.

Continue reading “Hundreds of websites worldwide go DOWN including Netflix and Spotify” »

The U.S. Department of Treasury and NASA did not immediately respond to CNBC’s requests for comment.

Launched in 1998, the ISS serves as the largest hub for scientific research and collaboration in orbit. The U.S., Russia, Canada and Japan alongside a dozen countries participating in the European Space Agency work in support of the ISS.

Is the physical universe independent from us, or is it created by our minds, as suggested by scientist Robert Lanza?

During a recent #MQ25 T1 test asset flight, this unmanned aerial refueler for the @USNavy delivered fuel to an F/A-18 #SuperHornet — the first time an unmanned aircraft has ever refueled another aircraft.

June 10 marks the first solar eclipse of any kind viewable in North America since 2017.

The ring of fire annular solar eclipse in June is the first solar eclipse viewable in North America since 2017. Here’s how to watch and what makes it special.

While carrying out high-throughput chromosome conformation capture (Hi-C) analysis on stage 8 (s8) X. tropicalis embryos, we noticed that chromatin interactions plotted at 100-kilobase (kb) resolution using the reference genome v.9.1 showed inversions, misplacements and gaps in nearly every chromosome (Fig. 1a and Extended Data Fig. 1). Thus, to accurately characterize the genome folding patterns in X. tropicalis, we conducted a de novo genome assembly of X. tropicalis using Hi-C and single-molecule sequencing^42,43,44 (Fig. 1b). The newly assembled genome fixed most misplacements, inversions and gaps (Fig. 1c, d, Extended Data Fig. 2 and Supplementary Fig. 1). This new version of the genome was also longer (Supplementary Table 1 and Fig. 1e) and centromere interactions can now be detected (Supplementary Fig. 2). During the preparation of this work, v.10.0 of the X. tropicalis genome was released. While both v.10.0 and our assembly fixed major errors, both versions are still flawed with visually identifiable errors (Supplementary Fig. 1; blue and green arrows). A comparison of the three versions is shown in Supplementary Table 1. Conclusions from the following analyses are the same whether we used v.10.0 or our assembled genome.

To examine when the 3D chromatin architecture is established in X. tropicalis, we generated in situ Hi-C maps on hand-picked s8 embryos (Fig. 2a). A high-resolution (5-kb) inspection of chromatin contact heatmaps failed to reveal any distinct patterns (Fig. 2b), indicating the lack of structural organization before MBT. Next, we determined whether chromatin structures will emerge when rapid synchronized cell division ends by carrying out in situ Hi-C on s9 embryos. Although weak, TAD-like structures appeared across chromatin contact heatmaps (Fig. 2b), suggesting that TAD structures start forming as MBT begins in X. tropicalis.

We continued to examine the changes in chromatin conformation at later developmental stages (stages 10, 11, 12, 13, 15, 17, and 23) after major ZGA (Fig. 2b). TAD boundaries increased progressively from 2471 at s9 to 3000 at s11 (Extended Data Fig. 3a, b). This level was maintained throughout the later developmental stages and with relatively stable median TAD sizes (Extended Data Fig. 3a, b). Consistent with this pattern, the percentage of the genome folded into TADs positively correlated with the number of TADs established at each stage (Extended Data Fig. 3c). Overall, TAD borders were stable during development (Fig. 2c) and contained a high level of gene expression (Extended Data Fig. 3D, e).

In a new study published in ‘Nature’, scientists have discovered a major hallmark of the aging process and how to reverse the accompanying cognitive decline.

A new technology could dramatically improve the safety of lithium-ion batteries that operate with gas electrolytes at ultra-low temperatures. Nanoengineers at the University of California San Diego developed a separator—the part of the battery that serves as a barrier between the anode and cathode—that keeps the gas-based electrolytes in these batteries from vaporizing. This new separator could, in turn, help prevent the buildup of pressure inside the battery that leads to swelling and explosions.

“By trapping gas molecules, this separator can function as a stabilizer for volatile electrolytes,” said Zheng Chen, a professor of nanoengineering at the UC San Diego Jacobs School of Engineering who led the study.

The new separator also boosted battery performance at ultra–low temperatures. Battery cells built with the new separator operated with a high capacity of 500 milliamp-hours per gram at-40 C, whereas those built with a commercial separator exhibited almost no capacity. The battery cells still exhibited high capacity even after sitting unused for two months—a promising sign that the new separator could also prolong shelf life, the researchers said.