Albert Einstein’s most famous equation, E = mc2, used in the theory of general relativity, has been used to create matter from light, scientists have said in a new study.
Researchers from New York’s Brookhaven National Laboratory used the Department of Energy’s Relativistic Heavy Ion Collider (RHIC), ordinarily used for nuclear physics research, to speed up two gold ions that are positively charged, in a loop.
Spot is onsite at the Autodesk Technology Center in Boston. Learn how you can join them to research robotics in construction innovations and efficiencies.
CFP to explore new uses for robot dog Spot with Autodesk.
Researchers at the Baltimore-based biotech company Delfi Diagnostics have developed a machine learning-based blood testing technology that could greatly help detect early stages of lung cancer.
The researchers are hoping that improved screening and detection technologies could allow more cases of lung cancer to be spotted earlier, which could greatly improve outcomes.
“These results suggest that the Delfi lung cancer screening technology could help reduce lung cancer deaths by offering a convenient, high-performing test to people who are [United States Preventive Services Taskforce] eligible,” Delfi CMO Peter Bach said in a statement.
“We have already begun enrollment of a 1,700-patient, prospective, case-control study to generate the clinical evidence that would underpin a commercial lung screening test,” he added.
At Tesla AI Day, Elon Musk and his team of engineers unveil a prototye humanoid robot, the Tesla Bot. In addition, the status of the company’s full self driving technology.
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Denisovan DNA lives on in some humans today because, once our Homo sapien ancestors encountered the Denisovans, they had sex with them and gave birth to babies — something geneticists call admixture. By analyzing current-day genetic data, we can look back into human history.
Geneticists have found that a Philippine ethnic group known as the Ayta Magbukon has the highest level of Denisovan ancestry in the world.
Researchers have developed a the first two-dimensional supersolid! And it could open a new spectrum of quantum weirdness for further studies.
A group of scientists has grown mini brains that have something their real counterparts do not: a set of eye-like structures called “optic cups” that give rise to the retina.
Inspiration4 is preparing for liftoff.
The all-civilian mission is not only the first of its kind in history. It also marks a milestone for Musk’s company, which hopes to one day help humans live across the galaxy.
This is a huge, fairly sci-fi goal, but the trailblazing Inspiration4 crew could help the general public believe in it. And a Netflix documentary certainly doesn’t hurt.
I am pleased to announce that my lead-author review paper has been published in ACS Nano! If you are interested in learning about the convergence of synthetic biology and adenoviral gene therapy, I encourage you to check out my paper.
If you cannot access the full text, I have also posted a local copy at the following link: https://logancollinsblog.files.wordpress.com/2021/08/synthet…s-2021.pdf.
#ACS #ACSNano #SyntheticBiology #GeneTherapy #Biology #Biotech #Science #Biotechnology #Nanotechnology #Adenovirus #Engineering #Virology
Synthetic biology centers on the design and modular assembly of biological parts so as to construct artificial biological systems. Over the past decade, synthetic biology has blossomed into a highly productive field, yielding advances in diverse areas such as neuroscience, cell-based therapies, and chemical manufacturing. Similarly, the field of gene therapy has made enormous strides both in proof-of-concept studies and in the clinical setting. One viral vector of increasing interest for gene therapy is the adenovirus (Ad). A major part of the Ad’s increasing momentum comes from synthetic biology approaches to Ad engineering. Convergence of gene therapy and synthetic biology has enhanced Ad vectors by mitigating Ad toxicity in vivo, providing precise Ad tropisms, and incorporating genetic circuits to make smart therapies which adapt to environmental stimuli. Synthetic biology engineering of Ad vectors may lead to superior gene delivery and editing platforms which could find applications in a wide range of therapeutic contexts.
Many drugs show promising results in laboratory research but eventually fail clinical trials. We hypothesize that one main reason for this translational gap is that current cancer models are inadequate. Most models lack the tumor-stroma interactions, which are essential for proper representation of cancer complexed biology. Therefore, we recapitulated the tumor heterogenic microenvironment by creating fibrin glioblastoma bioink consisting of patient-derived glioblastoma cells, astrocytes, and microglia. In addition, perfusable blood vessels were created using a sacrificial bioink coated with brain pericytes and endothelial cells. We observed similar growth curves, drug response, and genetic signature of glioblastoma cells grown in our 3D-bioink platform and in orthotopic cancer mouse models as opposed to 2D culture on rigid plastic plates. Our 3D-bioprinted model could be the basis for potentially replacing cell cultures and animal models as a powerful platform for rapid, reproducible, and robust target discovery; personalized therapy screening; and drug development.
Cancer is the second leading cause of death globally. It is estimated that around 30 to 40% of patients with cancer are being treated with ineffective drugs ; therefore, preclinical drug screening platforms attempt to overcome this challenge. Several approaches, such as whole-exome or RNA sequencing (RNA-seq), aim to identify druggable, known mutations or overexpressed genes that may be exploited as a therapeutic target for personalized therapy. More advanced approaches offer to assess the efficacy of a drug or combinations of drugs in patient-derived tumor xenograft models or in vitro three-dimensional (3D) organoids. Unfortunately, most of the existing methods face unmet challenges, which limit their efficacy. For instance, cells can become quiescent or acquire somatic mutations while growing many generations on plastic under the influence of static mechanical forces and in the absence of functional vasculature.
