Lifeboat Foundation

In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.

Today, we chronicle the progress of partial cellular reprogramming and discuss how this powerful treatment may be able to reprogram cells back into a youthful state, at least partially reversing epigenetic alterations, one of the proposed reasons we age.

For those of you new to the subject of epigenetic alterations you can learn more by clicking on the topic box below, for the more seasoned readers, feel free to skip ahead.

# **The SRIC3 Program is now online!**

Space Renaissance just published the Program of the SRIC3 World Congress The Civilian Space Development\.

Continue reading “Schedule Space Renaissance” »

About 10 years ago, researchers at the University of Bonn produced an extreme aggregate photon state, a single “super-photon” made up of many thousands of individual light particles, and presented a completely new light source. The state is called an optical Bose-Einstein condensate and has captivated many physicists ever since, because this exotic world of light particles is home to its very own physical phenomena. Researchers led by Prof. Dr. Martin Weitz, who discovered the super photon, and theoretical physicist Prof. Dr. Johann Kroha now report a new observation: a so-called overdamped phase, a previously unknown phase transition within the optical Bose-Einstein condensate. The study has been published in the journal Science.

The Bose-Einstein condensate is an extreme physical state that usually only occurs at very low temperatures. The particles in this system are no longer distinguishable and are predominantly in the same quantum mechanical state; in other words, they behave like a single giant “superparticle.” The state can therefore be described by a single wave function.

In 2010, researchers led by Martin Weitz succeeded for the first time in creating a Bose-Einstein condensate from light particles (photons). Their special system is still in use today: Physicists trap light particles in a resonator made of two curved mirrors spaced just over a micrometer apart that reflect a rapidly reciprocating beam of light. The space is filled with a liquid dye solution, which serves to cool down the photons. The dye molecules “swallow” the photons and then spit them out again, which brings the light particles to the temperature of the dye solution—equivalent to room temperature. The system makes it possible to cool light particles because their natural characteristic is to dissolve when cooled.

Bipolar disorder affects millions of Americans, causing dramatic swings in mood and, in some people, additional effects such as memory problems.

While bipolar disorder is linked to many genes, each one making small contributions to the disease, scientists don’t know just how those genes ultimately give rise to the disorder’s effects.

However, in new research, scientists at the University of Wisconsin-Madison have found for the first time that disruptions to a particular protein called Akt can lead to the brain changes characteristic of bipolar disorder. The results offer a foundation for research into treating the often-overlooked cognitive impairments of bipolar disorder, such as memory loss, and add to a growing understanding of how the biochemistry of the brain affects health and disease.

A new, detailed model of the surface of the SARS-CoV-2 spike protein reveals previously unknown vulnerabilities that could inform development of vaccines. Mateusz Sikora of the Max Planck Institute of Biophysics in Frankfurt, Germany, and colleagues present these findings in the open-access journal PLOS Computational Biology.

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. A key feature of SARS-CoV-2 is its spike protein, which extends from its surface and enables it to target and infect human cells. Extensive research has resulted in detailed static models of the spike protein, but these models do not capture the flexibility of the spike protein itself nor the movements of protective glycans—chains of sugar molecules—that coat it.

To support vaccine development, Sikora and colleagues aimed to identify novel potential target sites on the surface of the spike protein. To do so, they developed molecular dynamics simulations that capture the complete structure of the spike protein and its motions in a realistic environment.

Great new episode with Michael Seiffert, the NASA project scientist for the U.S. contribution to the European Space Agency’s Euclid spacecraft. Seiffert talks candidly about what it takes to strike a balance between risk and reward in the design of this upcoming $1 billion dollar dark energy mission.

Fascinating new chat with Michael Seiffert, the NASA project scientist for the U.S. contribution to the European Space Agency’s Euclid spacecraft. Due for launch in the second half of 2022, we discuss how this new space telescope will help astronomers finally understand the mystery of dark energy and maybe even dark matter.

Continue reading “Episode 44 --- ESA’s Upcoming Euclid Dark Energy Survey” »

With an internal global ocean twice the size of Earth’s oceans combined, Jupiter’s moon Europa carries the potential for conditions suitable for life. But the frigid temperatures and the nonstop pummeling of the surface from Jupiter’s radiation make it a tricky target to explore: Mission engineers and scientists must design a spacecraft hardy enough to withstand the radiation yet sensitive enough to gather the science needed to investigate Europa’s environment.

The Europa Clipper orbiter will swoop around Jupiter on an elliptical path, dipping close to the moon on each flyby to conduct detailed reconnaissance. The science includes gathering measurements of the internal ocean, mapping the surface composition and its geology, and hunting for plumes of water vapor that may be venting from the icy crust.

Applied Materials CEO Gary Dickerson’s formula for success isn’t magic. “Being close to the customer,” he said, is the lesson that’s guided him.