Lifeboat Foundation

Not sure how interesting this will be to people who know a lot on aging/longevity research.

A team of researchers at Brigham and Women’s Hospital and Harvard Medical School have found evidence of mouse and human germline cells resetting their biological age. In their paper published in the journal Science Advances, the group describes their study of the aging process in germline cells and what they found by doing so.

As animals grow older, all of the cells in their body replicate themselves repeatedly. As the process continues, errors in replicating and other external factors (such as exposure to pollutants) lead to gradual decay in cell quality, which is all part of the natural aging process. In this new effort, the researchers have found evidence showing that germline cells have a mechanism for resetting this process, allowing offspring to reset their aging clocks.

Continue reading “Mouse and human germline cells appear to reset their biological age” »

A team of biohackers is on a David-versus-Goliath mission to make insulin affordable to an increasing number of diabetics.

The human body contains hundreds of different types of cells, with stem cells working like blank canvases that can be adapted and reproduced to help our tissues grow and repair themselves. However, once hijacked, the same kind of cell proliferation can be damaging, as happens in cancer tumors.

Scientists have now discovered a new resting phase for neuroepithelial cells — the stem cells of the central nervous system — which appears to put them in a kind of dormancy. If we can work out how to apply this to cancer cells too, we could get to the stage of being able to put brain tumors to ‘sleep’.

“The primary feature of any cancer is that the cells are proliferating,” says biomedical engineer Christopher Plaisier, from Arizona State University. “If we could get in there and figure out what the mechanisms are, that might be a place to slow them down.”

Experts are excited by the concept of microreactors because nuclear facilities have historically relied on economies of scale — a paradigm this tech could reverse.

“Microreactors promise to turn this paradigm on its head by approaching cost competitiveness through technological learning,” Alex Gilbert from the nuclear power think tank Nuclear Innovation Alliance, told CNBC.

Oklo’s “fast reactor” plant uses energy from already-spent nuclear reactor fuel, technology that has been around since the 1950s, according to CNBC.

WHO certifies country free of the deadly disease after 3 years without local transmission.

Walmart will offer a less expensive private label version of analog insulin for diabetes patients who struggle to afford their medication, the retail and pharmacy giant said June 29.

Novo Nordisk will manufacture the insulin, called ReliOn NovoLog. Walmart said it will become available at Walmart pharmacies the week of June 27 and at Sam’s Club pharmacies in mid-July.

A vial of ReliOn NovoLog will cost $72.88, and a package of prefilled pens will cost $85.88. Walmart said these products will save patients between 58 and 75 percent of the price of other insulin products on the market.

Papers referenced in the video:

Loss of Life Expectancy by 10 Years or More From Elevated Aspartate Aminotransferase: Finding Aspartate Aminotransferase a Better Mortality Predictor for All-Cause and Liver-Related than Alanine Aminotransferase.
https://pubmed.ncbi.nlm.nih.gov/31425154/

Continue reading “Aspartate Aminotransferase: What’s Optimal, And Can It Be Improved?” »

The ability to precisely control the various properties of laser light is critical to much of the technology that we use today, from commercial virtual reality (VR) headsets to microscopic imaging for biomedical research. Many of today’s laser systems rely on separate, rotating components to control the wavelength, shape and power of a laser beam, making these devices bulky and difficult to maintain.

Now, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences have developed a single metasurface that can effectively tune the different properties of laser light, including wavelength, without the need of additional optical components. The metasurface can split light into multiple beams and control their shape and intensity in an independent, precise and power-efficient way.

The research opens the door for lightweight and efficient optical systems for a range of applications, from quantum sensing to VR/AR headsets.

It’s a problem that few of us will likely ever face: once you’ve built your first homemade integrated circuit, what do you do next? If you’re [Sam Zeloof], the answer is clear: build better integrated circuits.

At least that’s [Sam]’s plan, which his new reactive-ion etching setup aims to make possible. While his Z1 dual differential amplifier chip was a huge success, the photolithography process he used to create the chip had its limitations. The chemical etching process he used is a bit fussy, and prone to undercutting of the mask if the etchant seeps underneath it. As its name implies, RIE uses a plasma of highly reactive ions to do the etching instead, resulting in finer details and opening the door to using more advanced materials.

Continue reading “Garage Semiconductor Fab Gets Reactive-Ion Etching Upgrade” »