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Aug 26, 2019

Disappearing act: Device vanishes on command after military missions

Posted by in categories: materials, military

A polymer that self-destructs? While once a fictional idea, new polymers now exist that are rugged enough to ferry packages or sensors into hostile territory and vaporize immediately upon a military mission’s completion. The material has been made into a rigid-winged glider and a nylon-like parachute fabric for airborne delivery across distances of a hundred miles or more. It could also be used someday in building materials or environmental sensors.

The researchers will present their results today at the American Chemical Society (ACS) Fall 2019 National Meeting & Exposition.

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Aug 26, 2019

Scientists find longevity biomarkers

Posted by in categories: genetics, life extension

An international group of scientists studied the effects of 17 lifespan-extending interventions on gene activity in mice and discovered genetic biomarkers of longevity. The results of their study were published in the journal Cell Metabolism.

Nowadays, dozens of interventions are known that extend the lifespan of various living organisms ranging from yeast to mammals. They include chemical compounds (e.g. rapamycin), genetic interventions (e.g. mutations associated with disruption of growth hormone synthesis), and diets (e.g. caloric restriction). Some targets of these interventions have been discovered. However, there is still no clear understanding of the systemic molecular mechanisms leading to lifespan extension.

A group of scientists from Skoltech, Moscow State University and Harvard University decided to fill this gap and identify crucial molecular processes associated with longevity. To do so, they looked at the effects of various lifespan-extending interventions on the activity of in a mouse, a commonly used model organism closely related to humans.

Aug 26, 2019

Uh-oh: Silicon Valley is building a Chinese-style social credit system

Posted by in categories: government, law, policy

In China, scoring citizens’ behavior is official government policy. U.S. companies are increasingly doing something similar, outside the law.

[Images: Rawf8/iStock; zhudifeng/iStock].

Aug 26, 2019

Margaret has the brain of someone decades younger. What’s her secret?

Posted by in category: neuroscience

Meet Margaret, the Super Ager — could people like her teach us how to keep our brains younger for longer?

Aug 26, 2019

Researchers Created AI That Hides Your Emotions From Other AI

Posted by in categories: internet, robotics/AI

Humans can communicate a range of nonverbal emotions, from terrified shrieks to exasperated groans. Voice inflections and cues can communicate subtle feelings, from ecstasy to agony, arousal and disgust. Even when simply speaking, the human voice is stuffed with meaning, and a lot of potential value if you’re a company collecting personal data.

Now, researchers at the Imperial College London have used AI to mask the emotional cues in users’ voices when they’re speaking to internet-connected voice assistants. The idea is to put a “layer” between the user and the cloud their data is uploaded to by automatically converting emotional speech into “normal” speech. They recently published their paper “Emotionless: Privacy-Preserving Speech Analysis for Voice Assistants” on the arXiv preprint server.

Our voices can reveal our confidence and stress levels, physical condition, age, gender, and personal traits. This isn’t lost on smart speaker makers, and companies such as Amazon are always working to improve the emotion-detecting abilities of AI.

Aug 26, 2019

Study: Blood test detects concussion and subconcussive injuries in children and adults

Posted by in categories: biotech/medical, health, neuroscience

In one of the largest studies of its kind, researchers at Orlando Health are making new progress in finding ways to detect a traumatic yet sinister brain injury—and getting closer to preventing further damage.

Subconcussive injuries often show no symptoms or immediate effects, but can cause wear and tear on the brain over time with repeated injuries. The latest study, published in the journal BMJ Paediatrics Open, includes more than 700 emergency room patients—children and adults. The study gets us closer to developing a standard blood test to spot these injuries as early as possible.

“A unique feature of this study is that it includes patients who hit their heads but have no symptoms,” said Linda Papa, MD, lead author of the study and emergency medicine doctor at Orlando Health. “This group is rarely—if ever—included in biomarker studies.”

Aug 26, 2019

The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction

Posted by in categories: biotech/medical, food

Mammals evolved in the face of fluctuating food availability. How the immune system adapts to…

Aug 26, 2019

Rejuvenation Research Is Now a Mainstream Topic

Posted by in category: life extension

It is a sure sign that the tide has turned when mainstream news outlets and magazines start publishing positive articles about aging research and the prospects of rejuvenation.

A refreshing change

Today, I want to highlight an article in MIT Technology Review in which the author, David Adam, gives a sensible and measured overview of what is happening in the field and manages to sidestep the usual negativity and misconceptions that often plague popular science pieces.

Aug 26, 2019

Researchers identify key areas of measles virus polymerase to target for antiviral drug development

Posted by in categories: biotech/medical, health

ATLANTA—Targeting specific areas of the measles virus polymerase, a protein complex that copies the viral genome, can effectively fight the measles virus and be used as an approach to developing new antiviral drugs to treat the serious infectious disease, according to a study by the Institute for Biomedical Sciences at Georgia State University published in PLoS Pathogens.

Measles is a highly contagious virus that can lead to serious health complications and death. It begins with a fever, cough, runny nose and red eyes followed by a rash of tiny, red spots that starts at the head and spreads to the rest of the body. Although declared eliminated in the United States in 2000, the Centers for Disease Control and Prevention says the U.S. is experiencing the greatest number of measles cases reported since the early 1990s.

While an effective vaccine exists, there has been a steady decline in the number of people being vaccinated against the measles virus. Most new cases were among unvaccinated individuals, making the development of an effective treatment strategy complementing vaccination a public health priority. There are no antivirals licensed to treat measles. The new study identified a novel protein interface in the polymerase complex that is pivotal for the regulation of polymerase activity, providing a new objective for target-based antiviral drug discovery.

Aug 26, 2019

Drugs that target cell metabolism may lead to new treatment for childhood brain cancer

Posted by in categories: biotech/medical, chemistry, genetics, neuroscience

Scientists have identified a class of drugs that may have potential to treat a rare and deadly form of brain cancer that affects young children.

The research team, led by Ranjit Bindra, MD, PhD, and colleagues at the Yale Cancer Center, also included co-senior authors Charles Brenner, PhD, professor and DEO of biochemistry at the University of Iowa Carver College of Medicine, and Michael E. Berens, PhD, from the Translational Genomics Research Institute in Phoenix.

The findings, published Aug. 22 in Nature Communications, focus on Diffuse Intrinsic Pontine Glioma (DIPG), a rare, incurable cancer that affects the brainstem in children under age 10. Previous work had identified mutations in a gene called PPM1D as a cause of this cancer.