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This is an emerging therapeutic technique that works by targeting the underlying causes of a disease, rather than the symptoms it causes. It does this by targeting a particular gene, and preventing it from making the protein that it produces.

The United Kingdom’s NHS has very recently approved a new cholesterol-lowering jab which will be offered to 300,000 people over the next three years.

The drug – inclisiran – will be administered twice a year as an injection.

It will mainly be prescribed to patients who suffer with a genetic condition that leads to high cholesterol, those who have already suffered a heart attack or stroke, or those who haven’t responded well to other cholesterol-lowering drugs, such as statins.

Continue reading “A Clever ‘Gene Silencing’ Injection Has Been Approved For Treating High Cholesterol” | >

X-Prize board member Sergey Young on his new book, and the potential for a longevity X-Prize.

“We have created science and technology to extend our life, but we haven’t created life we want to extend.”–Sergey Young, Seeking Delphi™ episode #55, explaining why he believes more people do not support radical life extension.

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Physicists at The Australian National University (ANU) have developed extremely powerful microscopic lasers that are even smaller than the wavelength of the light they produce. So called ‘nanolasers’ have a huge variety of medical, surgical, industrial and military uses, covering everything from hair removal to laser printers and night-time surveillance. According to lead researcher Professor Yuri Kivshar, the nanolasers developed by his team promise to be even more powerful than existing lasers, allowing them to be useful in smaller-scale devices. “They can also be integrated on a chip,” he said.

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One of the many areas graphene promises to have transformative effects is in fortifying construction materials like concrete and asphalt. A first-of-a-kind trial now underway seeks to apply the wonder material’s impressive attributes to one of the UK’s major thoroughfares, by deploying it in a road resurfacing project along a stretch of the A1 motorway.

Made up of a single sheet of carbon atoms arranged in a honeycomb pattern, graphene offers incredible strength and flexibility, and by incorporating it into materials like asphalt scientists hope to develop road surfaces that last far longer, and therefore cost less to maintain.

Back in 2017 we looked at an interesting take on this from a pair of Italian companies that developed an asphalt material doped with a graphene additive to make it less likely to soften in the heat and crack in the cold under high loads. This product, known as Gipave, also incorporates plastic pellets and was recently rolled out along stretches of UK roads as part of trials to see how it can extend the lifespan of the surface.

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California-based startup Relativity Space is manufacturing rockets using giant Westworld-esque 3D printers, a process they say could drastically shorten the rocket-making process from years to weeks. Tim Ellis, the company’s 30-year-old CEO, explains how the high degree of automation in Relativity’s factory has enabled them to build rockets remotely during the Covid-19 pandemic.

#Coronavirus #Space #HelloWorld.
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Continue reading “The SpaceX Competitor is Printing Its Rockets” | >

The results provide a blueprint for finding such systems in the universe’s quieter, emptier regions.

By definition, dwarf galaxies are small and dim, with just a fraction of the stars found in the Milky Way and other galaxies. There are, however, giants among the dwarfs: Ultra-diffuse galaxies, or UDGs, are dwarf systems that contain relatively few stars but are scattered over vast regions. Because they are so diffuse, these systems are difficult to detect, though most have been found tucked within clusters of larger, brighter galaxies.

Now astronomers from MIT.

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Technically, several attempts have been made to automate text replacement in still images based on principles of deep style transfer. The research group is including this progress and their research to tackle the problem of text replacement in videos. Videotext replacement is not an easy task. It must meet the challenges faced in still images while also accounting for time and effects such as lighting changes, blur caused by camera motion or object movement.

One approach to solve video-test replacement could be to train an image-based text style transfer module on individual frames while incorporating temporal consistency constraints in the network loss. But with this approach, the network performing text style transfer will be additionally burdened with handling geometric and motion-induced effects encountered in the video.

Therefore, the research group took a very different approach. First, they extract text regions of interest (ROI) and train a Spatio-temporal transformer network (STTN) to Frontalize the ROIs so that they will be temporally consistent. Next, they scan the video and select a reference frame with high text quality which was measured in terms of text sharpness, size, and geometry.

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