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University of California-Riverside (UCR) researchers say they are studying whether they can turn edible plants like lettuce into mRNA vaccine factories.

One of the challenges with this new technology is that it must be kept cold to maintain stability during transport and storage. If this new project is successful, plant-based mRNA vaccines, which can be eaten, could overcome this challenge with the ability to be stored at room temperature.

The project’s goals, made possible by a $500,000 grant from the National Science Foundation, are threefold: showing that DNA containing the mRNA vaccines can be successfully delivered into the part of plant cells where it will replicate, demonstrating the plants can produce enough mRNA to rival a traditional shot, and finally, determining the right dosage.

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Prof. Chuanfeng Li and Prof. Zongquan Zhou from University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) innovatively raised and realized noiseless photon echo (NLPE) protocol. The research of entire originality reduced the noise by 670 times compared with previous strategies and achieved solid quantum memory with high fidelity. The results were published in Nature Communications.

First observed by Erwin Hahn in 1,950 photon echo is a fundamental physical interaction between light and matter as well as an essential tool for the manipulation of electromagnetic fields. However, the intense spontaneous noise emission generated has the same frequency as the signal, it is impossible to separate them in principle. Previous protocols, such as atomic frequency comb and the revival of silenced echo, failed to eliminate the spontaneous noise emission as much as needed.

In this study, the researchers implemented NLPE protocol in Eu3+:Y2SiO5 crystal to serve as an optical quantum memory and applied a four-level aromic system to suppress the noise.

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Summary: Researchers identified specific receptors for acetylcholine that reroute information flow through memory circuits in the hippocampus. The findings could have implications for the development of drugs to help enhance or protect memory from diseases associated with cognitive decline.

Source: University of Bristol.

Bristol-led research has identified specific drug targets within the neural circuits that encode memories, paving the way for significant advances in the treatment of a broad spectrum of brain disorders.

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Progress.

Replacing or editing disease-causing mutations holds great promise for treating many human diseases. Yet, delivering therapeutic genetic modifiers to specific cells in vivo has been challenging, particularly in large, anatomically distributed tissues such as skeletal muscle. Here, we establish an in vivo strategy to evolve and stringently select capsid variants of adeno-associated viruses (AAVs) that enable potent delivery to desired tissues. Using this method, we identify a class of RGD motif-containing capsids that transduces muscle with superior efficiency and selectivity after intravenous injection in mice and non-human primates. We demonstrate substantially enhanced potency and therapeutic efficacy of these engineered vectors compared to naturally occurring AAV capsids in two mouse models of genetic muscle disease. The top capsid variants from our selection approach show conserved potency for delivery across a variety of inbred mouse strains, and in cynomolgus macaques and human primary myotubes, with transduction dependent on target cell expressed integrin heterodimers.

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The label on RecA together with fluorescent markers on the DNA allows the researchers to follow every step of the process accurately; for example, they conclude that the whole repair is finished in 15 minutes, on average, and that the template is located in about nine. Using microscopy, Elf and his team investigate the fate of the break site and its homologous copy in real-time. They also find that the cell responds by rearranging RecA to form thin filaments that span the length of the cell.

How the cell can mend broken DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

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Civilian Space Development has kicked-off: the work begins now!

Newsletter 17.09.2021 by Bernard Foing & Adriano V. Autino

During the last months we have seen the first civilian passengers fly to space, onboard Blue Origin and Virgin Galactic vehicles. September 15th, four civilian astronauts, onboard a Space X Dragon capsule, passed the 500 km orbit, more than 100 km higher than the ISS.In 2016 we started to publicly talk about and promote Civilian Space Development, while the whole space community kept on talking only about space exploration. Earlier, in 2,008 we founded the Space Renaissance movement, and a couple of years later the Space Renaissance International, as a philosophical association targeted to complete the Kopernican Revolution, supporting the Civilization expansion into space. Nowadays the concept of civilian space flight is everywhere on the media, and many people in the space community talk about a space renaissance. Of course the Coronavirus pandemics accelerated the awareness of the urgency to expand humanity into outer space. And space tourism — the first stage of civilian space settlement — is now a reality, in its first steps.

Of course nobody could be more happy than ourselves, for the above development, and of course**2 we want to congratulate with Elon, Richard and Jeff, for such a great achievement!

So, may we consider that our mission has been completed? Let’s see.

Firstly, were those crews composed by regular travelers, like normal air-flight passengers? Not exactly. The Inspiration4 crew members received astronaut training, for many months, including lessons in orbital mechanics, operating in a microgravity, stress testing, emergency preparedness training, and mission simulations. They have studied over 90 different kinds of training guides and manuals and lessons to learn to fly Crew Dragon, and what to do under emergency situations. The legal aspects are not clear: did FAA quickly authorize Space X and Blue Origin to deal commercial space flights? Doubt is more than legitimate, considering the long procedure followed by Virgin Galactic to be authorized to transport paying passengers in space. Likely, these first “civilian” passengers — like the first orbital tourist Dennis Tito did in 2001 — accepted conditions similar to the military astronauts (i.e. zero rights and warrants).

Continue reading “Civilian Space Development has kicked-off: the work starts now!” | >

“Ronapreve has been shown to improve survival in high-risk, non-hospitalised COVID-19 patients by reducing the risk of hospitalisation and death. In addition, its ability to retain activity against emerging variants, including the Delta variant, has been demonstrated in preclinical studies,” said Levi Garraway, M.D., Ph.D., Roche’s Chief Medical Officer and Head of Global Product Development. “Today’s approval brings hope to patients in Japan who can now access this important treatment option.”

Japan becomes first country to approve Ronapreve (casirivimab and imdevimab) for the treatment of mild to moderate COVID-19 in adults and paediatric patients (12 years of age and older weighing at least 40 kg) with positive results of direct SARS-CoV-2 viral testing, and who are at high risk for progression to severe COVID-19 and/or hospitalisation. The US EUA is temporary and does not take the place of the formal biologics license application (BLA) submission, review and approval process.

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The future of vaccines may look more like eating a salad than getting a shot in the arm. UC Riverside scientists are studying whether they can turn edible plants like lettuce into mRNA vaccine factories.

One of the challenges with this new technology is that it must be kept cold to maintain stability during transport and storage. If this new project is successful, plant-based mRNA vaccines — which can be eaten — could overcome this challenge with the ability to be stored at room temperature.

The project’s goals, made possible by a $500,000 grant from the National Science Foundation, are threefold: showing that DNA containing the mRNA vaccines can be successfully delivered into the part of plant cells where it will replicate, demonstrating the plants can produce enough mRNA to rival a traditional shot, and finally, determining the right dosage.

Read more | >

Watch the full documentary on Vimeo on demand: https://vimeo.com/ondemand/339083

The study of consciousness needs to be lifted out of the mysticism that has dominated it. Consciousness is not just a matter of philosophy or spirituality. It’s a matter of hard science. It’s a matter of understanding the brain and the mind — a pattern structure made out of information. It’s also a matter of engineering. If we can understand the functionality of the brain, its neural code, then we can build the same functionality into our computer systems. There’s no consensus on what produces consciousness, but everyone regardless of metaphysical views can agree what it is like to be conscious. Given that consciousness is subjectivity, what consciousness is like is what consciousness is.

‘Mind’ and ‘Consciousness’ are two different but somewhat overlapping terms related to the phenomenality of our experiential reality. Different species have a variety of their biological information processors which unsurprisingly results in qualia diversity. All species live in their own unique sensory universes. There is “something it is like to be” an organism. The human brain, our biological “wetware,” has a fractal structure on many genetic and abstract cognitive levels. Information is “modus operandi” of consciousness.

If we are to reason for the non-dual picture of the world then quantum physics is directly linked to consciousness. The human brain is a physical organ that transmits and interprets electrochemical signals. Its biochemistry is certainly governed by quantum physical laws, and consciousness — which is clearly related to the functioning of the brain — must therefore be related to the quantum physical processes going on within the brain and in the cosmos at large. Research has shown that consciousness is non-local, a scientific way of alluding to a connection within a higher dimensional order. Matter has also been shown to be non-local, which hints that matter might be an expression of consciousness, emerging from the ‘Unified Field’ — the quantum layer of pure potentiality — the code layer beneath all dimensions where time and space are information.

Continue reading “Consciousness: Evolution of the Mind, Documentary (2021), Official Teaser Trailer” | >

GM Defense, a subsidiary of General Motors, was recently awarded a contract to develop next-generation SUVs for the government’s fleet.

This specific contract was awarded by the US Department of State, and the vehicles will be built to support the Diplomatic Security Service. Diplomatic Security is a federal law enforcement agency charged with securing diplomatic assets and personnel. In 2,020 GM Defense also got the contract to build the army’s new infantry squad vehicle based on the Chevrolet Colorado ZR2. That particular contract was more extensive and, at the time of writing, valued at $213.4 million. The eventual goal was 2,065 vehicles.

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