Lifeboat Foundation

A team of researchers from Verve Therapeutics and the Perelman School of Medicine at the University of Pennsylvania has developed a CRISPR gene-editing technique that lowered the levels of cholesterol in the blood of test monkeys. In their paper published in the journal Nature, the researchers describe their technique.

Prior research has shown that in some people, the PCSK9 gene codes excess PCSK9 protein production (which occurs mostly in the liver)—leading to an increase in lipoprotein cholesterol levels in the bloodstream. This is because it interferes with blood cells with LDL receptors that “grab” LDL and remove it. For this reason, pharmaceutical companies have developed therapies that reduce the production of PCSK9 protein. However, most do not work well enough, which is why there is still so much atherosclerotic cardiovascular disease. In this new effort, the researchers have tried another approach—altering the PCSK9 gene to make it stop coding for PCSK9 protein production.

The approach involved using a base editing technology made up of messenger RNA encoding for an adenine base editor along with guided RNA that was packaged in a lipid nanoparticle. Notably, the base editing technique was able to substitute a single nucleotide with another in the DNA without cutting the double helix. Prior research has shown the technique to be more precise, which means fewer errors than other CRISPR techniques. In their work, the researchers replaced an adenine with a guanine and a thymine with a cytosine, completely incapacitating the gene. Implementation of the therapy involved a one-time injection into the liver of cynomolgus monkeys.

The scale-free complexity associated with the biological system in general, and the neuron in particular, means that within each cell there is a veritable macromolecular brain, at least in terms of structural complexity, and perhaps to a certain degree functional complexity as well—a fractal hierarchy. This means that the extremely simplistic view of the synapse as a single digital bit is misrepresenting the reality of the situation—such as, if we were to utilize the parlance of the neurocomputational model, each ‘computational unit’ contains a veritable macromolecular brain within it. There is no computer or human technology yet equivalent to this.\.

A study published in the journal Science has upended 80 years of conventional wisdom in computational neuroscience that has modeled the neuron as a simple point-like node in a system, integrating signals and passing them along.

Using a robotic ‘Third Thumb’ can impact how the hand is represented in the brain, finds a new study led by UCL researchers.

The team trained people to use a robotic extra thumb and found they could effectively carry out dextrous tasks, like building a tower of blocks, with one hand (now with two thumbs). The researchers report in the journal Science Robotics that participants trained to use the thumb also increasingly felt like it was a part of their body.

Designer Dani Clode began developing the device, called the Third Thumb, as part of an award-winning graduate project at the Royal College of Art, seeking to reframe the way we view prosthetics, from replacing a lost function, to an extension of the human body. She was later invited to join Professor Tamar Makin’s team of neuroscientists at UCL who were investigating how the brain can adapt to body augmentation.

Netra, co-founded by Shashi Kant SM ’06, uses artificial intelligence to help companies sort and manage video content.

At any given moment, many thousands of new videos are being posted to sites like YouTube, TikTok, and Instagram. An increasing number of those videos are being recorded and streamed live. But tech and media companies still struggle to understand what’s going in all that content.

Now MIT alumnus-founded Netra is using artificial intelligence to improve video analysis at scale. The company’s system can identify activities, objects, emotions, locations, and more to organize and provide context to videos in new ways.

Hundreds of newly detected gamma rays hint at cosmic environments that accelerate particles to extremes.

A new study by researchers from University of Oklahoma has found that the SARS-CoV-2 coronavirus could be causing a secondary medical condition known as Serum Amyloid A (SAA) Amyloidosis.

The proteins Serum amyloid A (SAA) are a family of apolipoproteins associated with high-density lipoprotein (HDL) in plasma. Different isoforms of SAA are expressed constitutively (constitutive SAAs) at different levels or in response to inflammatory stimuli (acute phase SAAs). These proteins are produced predominantly by the liver.

Sir Richard Branson’s spaceplane completes the first of three key test flights above New Mexico.

Russian state media calls the Satan II “invulnerable.”

Cryptocurrency mining operators, including a Huobi Mall and BTC.TOP, are suspending their China operations after Beijing stepped up its efforts to crack down on bitcoin mining and trading, sending the digital currency tumbling.

Cryptocurrency miners, including HashCow and BTC.TOP, have halted their China operations after Beijing intensified a crackdown on bitcoin mining and trading, hammering digital currencies amid heightened global regulatory scrutiny of them.

A State Council committee led by Vice Premier Liu He announced the crackdown late on Friday — the first time the council has targeted virtual currency mining, a big business in China that accounts for as much as 70% of the world’s crypto supply. read more

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