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ISM001-055 demonstrated highly promising results in multiple preclinical studies including in vitro biological studies, pharmacokinetic and safety studies. The compound significantly improved myofibroblast activation which contributes to the development of fibrosis. ISM001-055’s novel target is potentially relevant to a broad range of fibrotic indications.

“We are very pleased to see Insilico Medicine’s first antifibrotic drug candidate entering into the clinic,” said Feng Ren 0, PhD, CSO of Insilico Medicine. “We believe this is a significant milestone in the history of AI-powered drug discovery because to our knowledge the drug candidate is the first ever AI-discovered novel molecule based on an AI-discovered novel target. We have leveraged our end-to-end AI-powered drug discovery platform, including the usage of generative biology and generative chemistry, to discover novel biological targets and generate novel molecules with drug-like properties. ISM001-055 is the first such compound to enter the clinic, and we expect more to come in the near future [1].”

Previously, Insilico Medicine demonstrated its ability to generate drug-like hit molecules using AI with the publication of the Generative Tensorial Reinforcement Learning (GENTRL) system for a well-known target in record time [2]. It also demonstrated the target’s proof of concept by applying deep learning techniques for the identification of novel biological targets. This novel antifibrotic program combined these target discovery and generative chemistry capabilities. Notably, Insilico Medicine completed the entire discovery process from target discovery to preclinical candidate nomination within 18 months on a budget of $2.6 million.

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Circa 2019

You may have heard about Spyros Panapoulos Automotive (SPA) before. It made the news a few times in 2020 before things went quiet for a while, but now it’s back.

The Spyros Panapoulos Automotive Chaos was scheduled to debut at the 2021 Geneva Motor Show, but that never happened. Considering that this is a small startup that likely had a lot riding on the exposure it would have got had the show gone ahead, it’s no surprise that the company has been dormant.

Continue reading “The World’s Largest 3D Metal Printer Is Churning Out Rockets” | >

You may have heard about Spyros Panapoulos Automotive (SPA) before. It made the news a few times in 2020 before things went quiet for a while, but now it’s back.

The Spyros Panapoulos Automotive Chaos was scheduled to debut at the 2021 Geneva Motor Show, but that never happened. Considering that this is a small startup that likely had a lot riding on the exposure it would have got had the show gone ahead, it’s no surprise that the company has been dormant.

Now SPA has announced its revival on Facebook with a post that includes several images of the Chaos, all computer-generated. Commenters called SPA out on this, but CGI images often highlight certain features that are impossible to capture on camera. unfortunately, the post doesn’t reveal much other than the fact that only 20 units of the Chaos will be built and that models will be made available on every continent.

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Circa 2013 o.o

Earth dodged a gigantic space bullet Friday when the 143,000-ton asteroid known as 2012 DA14 came within 17,200 miles of the Indian Ocean. Scientists and engineers are looking for ways to head off such close calls by targeting potentially dangerous asteroids well before they’re in a position to do us any harm.

A group called the B612 Foundation (a reference to the home asteroid of the Little Prince in the classic French novella) recently announced a mission to build a spacecraft that would track dangerous midsize asteroids, and a fledgling company called Deep Space Industries has floated a plan to build swarms of robots that could mine — and even destroy — space rocks.

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Normally, computer chips consist of electronic components that always do the same thing. In the future, however, more flexibility will be possible: New types of adaptive transistors can be switched in a flash, so that they can perform different logical tasks as needed. This fundamentally changes the possibilities of chip design and opens up completely new opportunities in the field of artificial intelligence, neural networks or even logic that works with more values than just 0 and 1.

In order to achieve this, scientists at TU Wien (Vienna) did not rely on the usual silicon technology, but on . This was a success: The most in the world has now been produced using germanium. It has been presented in the journal ACS Nano. The special properties of germanium and the use of dedicated program gate electrodes made it possible to create a prototype for a new component that may usher in a new era of chip technology.

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Is expanding its lineup of ARM-based chips for Windows and Chromebook with Snapdragon 8cx Gen 3 and 7c+ Gen 3 platforms. In addition, the company aims to power handheld gaming devices using Snapdragon G3x Gen 1 chipsets.

Snapdragon 8cx Gen 3, which, is the first 5nm PC platform, according to Qualcomm, which designed it with ultra-slim and fanless laptops in mind. It says that moving to a 5nm process node and other optimizations allowed for improved Kryo CPU performance while sustaining similar power consumption levels as Gen 2 chipsets. The company claims the chipsets will deliver up to 85 percent improved performance compared with the previous generation and up to 60 percent better per-watt performance than x86 chips.

Along with 5G and WiFi 6/6E connectivity, the platform is said to offer multi-day battery life, upgraded camera and audio functions and chip-to-cloud security. Systems with 8cx Gen 3 chipsets will be able to take advantage of “29+ TOPS of AI acceleration,” which Qualcomm claims is three times the performance of “the leading competitive platform.” The AI acceleration could speed up tasks like face detection and background blur on calls. In addition, Snapdragon 8cx Gen 3 supports up to 4K HDR camera quality, and as many as four cameras.

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NASA and the U.S. Dept. of Energy have come together to solicit design proposals for a nuclear reactor that will power Lunar and Martian exploration!

Over the next fifteen years, multiple space agencies and their commercial partners intend to mount crewed missions to the Moon and Mars. In addition to placing “footprints and flags” on these celestial bodies, there are plans to establish the infrastructure to allow for a long-term human presence. To meet these mission requirements and ensure astronaut safety, several technologies are currently being researched and developed.

At their core, these technologies are all about achieving self-sufficiency in terms of resources, materials, and energy. To ensure that these missions have all the energy they need to conduct operations, NASA is developing a Fission Surface Power (FSP) system that will provide a safe, efficient, and reliable electricity supply. In conjunction with solar cells, batteries, and fuel cells, this technology will allow for long-term missions to the Moon and Mars in the near future.

For NASA, having fission reactors for lunar surface operations is a vital part of the Artemis Program, which aims to create a program of “sustained lunar exploration.” This means infrastructure is required, like the Lunar Gateway (where spacecraft will dock and resupply) and the Artemis Base Camp on the surface, where astronauts will eat, exercise, and sleep when not conducting extravehicular activities (EVAs) – i.e., surface operations.

Continue reading “NASA is Building a Nuclear Reactor to Power Lunar and Martian Exploration!” | >