Circa 2018
CRISPR will realize its potential in plastic and reconstructive surgery only if plastic surgeons gain familiarity with this disruptive technology and become active contributors and leaders in applying CRISPR to their respective areas of expertise.
Circa 2020
Self-propelling magnetic nanorobots capable of intrinsic-navigation in biological fluids with enhanced pharmacokinetics and deeper tissue penetration implicates promising strategy in targeted cancer therapy. Here, multi-component magnetic nanobot designed by chemically conjugating magnetic Fe3O4 nanoparticles (NPs), anti-epithelial cell adhesion molecule antibody (anti-EpCAM mAb) to multi-walled carbon nanotubes (CNT) loaded with an anticancer drug, doxorubicin hydrochloride (DOX) is reported. Autonomous propulsion of the nanobots and their external magnetic guidance is enabled by enriching Fe3O4 NPs with dual catalytic-magnetic functionality. The nanobots propel at high velocities even in complex biological fluids. In addition, the nanobots preferably release DOX in the intracellular lysosomal compartment of human colorectal carcinoma (HCT116) cells by the opening of Fe3O4 NP gate.
Circa 2017 using this can lead to near Ironman or foglet bodies with the ability to self heal the human body. It could be used on smartphones to heal people not needing a doctor in the future. This also would allow for the biological singularity to happen.
This device shoots new genetic code into cells to make them change their purpose. Researchers say the chip could someday be used to treat injuries in humans. But they’ve got a long, long way to go.
A once forgotten technology, RNA editing has been gaining traction as a treatment for genetic conditions given its key advantages over CRISPR gene editing.
Since CRISPR-Cas9 gene editing was first reported in 2012, its promise of making gene editing faster, cheaper, and easier than ever before led to an explosion in the number of publications referring to this gene editing technology.
An increasing number of research labs and companies are aiming to translate CRISPR gene editing into therapies for genetic diseases. However, further research has unveiled that there are more limitations to using CRISPR-Cas9 to cure diseases than initially expected. For example, the technology has been reported to introduce off-target changes to the DNA, raising concerns about its safety.
Novel study designed to correct genetic abnormalities of red blood cells.
Cleveland Clinic researchers are enrolling patients in a clinical trial that aims to work toward a cure for sickle cell disease, by changing the patient’s genetics. Sickle cell disease, a genetic blood disorder, is a painful and debilitating condition for which there are few approved therapies.
The multicenter study will evaluate the safety and effectiveness of a single dose of EDIT-301, an experimental one-time gene editing cell therapy that modifies a patient’s own blood-forming stem cells to correct the mutation responsible for sickle cell disease.
Continue reading “Cleveland Clinic Trial to Test Gene Therapy as Treatment of Sickle Cell Disease” »
This video explains the mendel’s law of segregation.
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The U.S. Space Development Agency has five satellites riding on SpaceX’s Transporter-2 mission scheduled to launch June 25.
WASHINGTON — The U.S. Space Development Agency has five satellites riding on SpaceX’s Transporter-2 rideshare mission scheduled to launch June 25.
“There’s nothing in the space business that gets your blood pumping like the idea of a launch, especially if you’ve got multiple satellites,” a senior Space Development Agency (SDA) official told reporters June 22. “We’re really excited about what’s going to happen.”
Continue reading “Space Development Agency to launch five satellites aboard SpaceX rideshare” »
It is hard for humans to wrap their heads around the fact that there are galaxies so far away that the light coming from them can be warped in a way that they actually experience a type of time delay. But that is exactly what is happening with extreme forms of gravitational lensing, such as those that give us the beautiful images of Einstein rings. In fact, the time dilation around some of these galaxies can be so extreme that the light from a single event, such as a supernova, can actually show up on Earth at dramatically different times. That is exactly what a team led by Dr. Steven Rodney at the University of South Carolina and Dr. Gabriel Brammer of the University of Copenhagen has found. Except three copies of this supernova have already appeared – and the team thinks it will show up again one more time, 20 years from now.
Finding such a supernova is important not just for its mind bending qualities – it also helps to settle an important debate in the cosmological community. The rate of expansion of the universe has outpaced the rate expected when calculated from the cosmic microwave background radiation. Most commonly, this cosmological conundrum is solved by invoking “dark energy” – a shadowy force that is supposedly responsible for increasing the acceleration rate. But scientists don’t actually know what dark energy is, and to figure it out they need a better model of the physics of the early universe.
One way to get that better model is to find an event that is actively being distorted through a gravitational lens. Importantly – the same event must show up at two separate, distinct times in order to provide input to a calculation about the ratio of the distance between the galaxy doing the lensing and the background galaxy that was the source of the event.
