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New mutation hotspot discovered in human genome

Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA can be passed down to future generations and are important for how we study genetics and disease.

The regions are located at the starting point of genes, also known as transcription start sites. These are sequences where cellular machinery starts to copy DNA into RNA. The first 100 base pairs after a gene’s starting point are 35% more prone to mutations compared with what you’d expect by chance, according to the study published in Nature Communications.

“These sequences are extremely prone to mutations and rank among the most functionally important regions in the entire human genome, together with protein-coding sequences,” explains Dr. Donate Weghorn, corresponding author of the study and researcher at the Center for Genomic Regulation in Barcelona.

X-Ray Imaging Uncovers Hidden Structures in Liquid-Metal-Grown Crystals

The delicate internal structure of platinum crystals growing in liquid metal has been revealed, according to new research employing a powerful X-ray technique that reveals new implications for quantum computing.

UNSW Professor Kourosh Kalantar-Zadeh, with the University of New South Wales (UNSW), led the study, which was reported in a recent paper in Nature Communications. The team behind the project has a history of specializing in exploiting liquid metals to produce new materials and green catalysts that improve industrial chemical reactions.

Abstract: Enhancing tumor cell susceptibility to macrophage-mediated phagocytosis in PancreaticCancer…

Deng Pan & team discover tumor pyrimidine synthesis shapes macrophage anti-tumor responses in mice, establishing a paradigm for tumor–macrophage metabolic crosstalk and revealing new therapeutic opportunities:

The figure shows inactivation of de novo pyrimidine synthesis promotes macrophage-mediated tumor control and phagocytosis.

1Department of Basic Medical Sciences, State Key Laboratory of Molecular Oncology, Tsinghua University, Beijing, China.

2Tsinghua-Peking Joint Centre for Life Sciences and.

3Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.

Organ-specific proteomic aging clocks predict disease and longevity across diverse populations

Wang, Xiao and colleagues develop and validate organ-specific proteomic aging clocks across large population cohorts in the UK, the USA and China, which show strong performance in tracking organ aging and predicting the risk of morbidity and mortality.

AI can speed antibody design

Extracellular ATP is an environmental cue in bacteria.

Extracellular ATP acts as a signal regulating physiology and immunity in eukaryotes and is elevated during intestinal infection or damage. Tronnet et al. show that extracellular ATP reprograms the transcriptional and metabolic landscapes of gut bacteria, impacting biofilm formation, production of bioactive metabolites, bacterial envelope composition, antimicrobial resistance, and virulence.

Scientists find cancer-fighting isotope hidden in accelerator waste

The photons in a particle accelerator’s beam dump are intense, high-energy radiation byproducts of the main physics experiment.

A team of researchers at the University of York states that this powerful radiation, specifically the photons, can be captured and repurposed. It can be utilized to create materials necessary for cancer treatment.

The target isotope, copper-67, is a highly valuable asset in oncology. The method shows potential for generating this rare isotope, which is used for both diagnosing and treating cancer.

Physicist delineates limits on the precision of quantum thermal machines

Quantum thermal machines are devices that leverage quantum mechanical effects to convert energy into useful work or cooling, similarly to traditional heat engines or refrigerators. Thermodynamics theory suggests that increasing the reliability with which all thermal machines produce the same thermodynamic processes in time comes at a cost, such as the wasted heat or the need for extra energy.

Drawing from theories and concepts rooted in thermodynamics, physicist Yoshihiko Hasegawa at the University of Tokyo recently set out to pinpoint the limits that would constrain the precision of finite-dimensional quantum thermal machines. In a recent paper, published in Physical Review Letters, he delineates these limits and shows that quantum coherence could reduce fluctuations, improving the accuracy of quantum thermal machines.

“Thermodynamic uncertainty relations have clarified an important ‘no free lunch’ principle: if you want an operation to be more precise, you must pay more thermodynamic cost, i.e., entropy production,” Hasegawa told Phys.org. “However, those thermodynamic uncertainty relations do not forbid, in principle, pushing entropy production arbitrarily high.

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