Extracellular ATP is an environmental cue in bacteria.
Extracellular ATP acts as a signal regulating physiology and immunity in eukaryotes and is elevated during intestinal infection or damage. Tronnet et al. show that extracellular ATP reprograms the transcriptional and metabolic landscapes of gut bacteria, impacting biofilm formation, production of bioactive metabolites, bacterial envelope composition, antimicrobial resistance, and virulence.
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