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Drugs that selectively kill senescent cells may benefit otherwise healthy older women but are not a “one-size-fits-all” remedy, Mayo Clinic researchers have found. Specifically, these drugs may only benefit people with a high number of senescent cells, according to findings publishing July 2 in Nature Medicine.

Senescent cells are malfunctioning cells in the body that lapse into a state of dormancy. These cells, also known as “zombie cells,” can’t divide but can drive chronic inflammation and tissue dysfunction linked to aging and chronic diseases. Senolytic drugs clear tissues of senescent cells.

In the 20-week, phase 2 randomized controlled trial, 60 healthy women past menopause intermittently received a senolytic combination composed of FDA-approved dasatinib and quercetin, a natural product found in some foods. It is the first randomized controlled trial of intermittent senolytic treatment in healthy aging women, and the investigators used bone metabolism as a marker for efficacy.

We’re using AI and Google Maps driving trends to optimize traffic light patterns and improve traffic flow. Stop-and-go traffic in urban areas causes 29 times more emissions than on open roads. Researchers at Google are partnering with cities around the globe, from Rio to Jakarta. So far, local governments have saved fuel and lowered emissions for nearly 30 million car rides every month. Learn more about this research at: https://g.co/research/greenlight.

If you are a city representative or traffic engineer and are interested in joining the waiting list, please complete this form: https://docs.google.com/forms/d/e/1FA…

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Large language models may enable real-time communication with extraterrestrial civilizations despite the vast distances between stars. We need to start thinking about what to tell them about us.

By Franck Marchis & Ignacio G. López-Francos

Patreon: https://www.patreon.com/seanmcarrollBlog post with audio player, show notes, and transcript: https://www.preposterousuniverse.com/podcast/2024/07/29…

Paracinsistent logic.

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Unlike classical computers, which use bits to process information as either 0s or 1s, quantum computers use quantum bits, also known as qubits, which can represent and process both 0 and 1 simultaneously thanks to a quantum property called superposition. This fundamental difference gives quantum computers the potential to solve some complex problems much more efficiently than classical computers.

INL researcher Ernesto Galvão, in collaboration with Sapienza Università di Roma (Rome) and Istituto di Fotonica e Nanotecnologie (Milan), recently published a groundbreaking study in the journal Science Advances (“Polarization-encoded photonic quantum-to-quantum Bernoulli factory based on a quantum dot source”), where they describe a new set-up for a quantum-to-quantum Bernoulli factory.

A Bernoulli factory is a method to manipulate randomness, using as inputs random coin flips with a certain probability distribution, and outputting coin flips with a different, desired distribution.

Researchers at Purdue University have trapped alkali atoms (cesium) on an integrated photonic circuit, which behaves like a transistor for photons (the smallest energy unit of light) similar to electronic transistors. These trapped atoms demonstrate the potential to build a quantum network based on cold-atom integrated nanophotonic circuits. The team, led by Chen-Lung Hung, associate professor of physics and astronomy at the Purdue University College of Science, published their discovery in the American Physical Society’s Physical Review X (“Trapped Atoms and Superradiance on an Integrated Nanophotonic Microring Circuit”).

“We developed a technique to use lasers to cool and tightly trap atoms on an integrated nanophotonic circuit, where light propagates in a small photonic ‘wire’ or, more precisely, a waveguide that is more than 200 times thinner than a human hair,” explains Hung, who is also a member of the Purdue Quantum Science and Engineering Institute. “These atoms are ‘frozen’ to negative 459.67 degrees Fahrenheit or merely 0.00002 degrees above the absolute zero temperature and are essentially standing still. At this cold temperature, the atoms can be captured by a ‘tractor beam’ aimed at the photonic waveguide and are placed over it at a distance much shorter than the wavelength of light, around 300 nanometers or roughly the size of a virus. At this distance, the atoms can very efficiently interact with photons confined in the photonic waveguide. Using state-of-the-art nanofabrication instruments in the Birck Nanotechnology Center, we pattern the photonic waveguide in a circular shape at a diameter of around 30 microns (three times smaller than a human hair) to form a so-called microring resonator. Light would circulate within the microring resonator and interact with the trapped atoms.”

A key aspect function the team demonstrates in this research is that this atom-coupled microring resonator serves like a ‘transistor’ for photons. They can use these trapped atoms to gate the flow of light through the circuit. If the atoms are in the correct state, photons can transmit through the circuit. Photons are entirely blocked if the atoms are in another state. The stronger the atoms interact with the photons, the more efficient this gate is.

There is also chaotic computation.

The study “Chaotic neural dynamics facilitate probabilistic computations through sampling,” published in the Proceedings of the National Academy of Sciences (PNAS), explores how the brain’s inherent chaos aids in processing information.

RIKEN researchers have developed a model to explain how the brain computes probabilities using chaotic dynamics.

A mathematical model suggests there is an unusual region of space where objects can get pulled into the sun’s orbit – meaning we may have to redraw the boundary of the solar system.

By Jonathan O’Callaghan